Exam V: CNS II

Question 1

Which negative effect causes the patient to be unable to experience pleasure?

Answer 1

Anhedonia

Question 2

Alogia and anhedonia are two negative symptoms caused by blockade of which pathway?

Answer 2

Mesocortical

Question 3

Negative vs. Positive Effects

Answer 3

Negative: affect flattening (lack of emotional expression), alogia (failure/slow to respond), avoliton (loss of activity), and anhedonia (unable to derive pleasure)

Positive: agitation, delusions, disorganized speech, disorganized thinking, hallucinations, and insomnia

Question 4

Manifestation of dry mouth, trouble urinating, and constipation are caused by which mechanism?

Answer 4

Muscarinic cholinoceptor blockage

Question 5

In atypical anti-psychotic drugs, what is the mechanism of action?

Answer 5

High affinity for 5-HT2 serotonin receptors

Question 6

Which atypical anti-psychotic drug has the least effect on weight gain?

Answer 6

Ziprasidone

Question 7

What anti-psychotic effect causes Parkinson’s symptoms?

Answer 7

D2 dopamine receptor blockage in the nigrostriatal pathway

Question 8

What is the emergency situation that begins with extreme muscle rigidity and uncontrollable BP?

Answer 8

NMS - Neuroleptic Malignant Syndrome

Question 9

Which anti-psychotic causes agranulocytosis/leukopenia (decreased WBC)?

Answer 9

Clozapine

Question 10

Which NT is schizophrenia associated with?

Answer 10

Dopamine hyperactivity

Question 11

Which atypical anti-psychotic causes the least amount of side effects?

Answer 11

Ziprasidone