Exam III Flashcards
Tendon
A flexible but inelastic cord of strong fibrous collagen tissue attaching a muscle to a bone
Ligament
A short band of tough, flexible, fibrous connective tissue that connects two bones or cartilages or holds together a joint to keep them stable
Functions of the skeletal system
Body support, organ protection, body movement, mineral storage, and blood cell production
Chondroblasts
Come from embryonic messenchymal cells. Produce bone matrix and fibers surrounding themselves, are entrapped in small spaces and turn into chondrocytes when the matrix has fully surrounded it
Chondrocyte
Rounded cell that occupies a space within the lacunae of the matrix
Fibrocartilage
Has a dense arrangement of cartilage fibers that are arranged in an orderly manner. Numerous chondrocytes are located within their lacunae and are spaced between the fibers. Fibrocartilage is primarily composed of type I collagen, and is located in areas like the intervertebral discs and the pubic symphysis. This is the strongest kind of cartilage, because it has alternating layers of hyaline cartilage matrix and thick layers of dense collagen fibres oriented in the direction of functional stresses
Hyaline cartilage
Most abundant type of cartilage in the body, a type of connective tissue. A precursor of bone. Growth in bone length and repair often involve making hyaline cartilage first, then replacing it with bone. High in collagen, helps hold the body together. Provides support and flexibility to different parts of the body. It is found in structures like the nose and areas where the ends of the ribs attach to the sternum
Elastic cartilage
Elastic cartilage provides strength, and elasticity, and maintains the shape of certain structure such as the external ear. It has a perichondrium
Hydroxyapatite
Main mineral of bone & teeth. Inorganic, basically a calcium phosphate crystal. Gives bones weight bearing strength
Collagen
Makes up the osteoid with ground substance, gives the matrix flexible strength (tensile strength)
Osteoblast
Bone forming cells, have an extensive endoplasmic reticulum and numerous ribosomes. Produce the osteoid (produces collagen and proteoglycans). Also release matrix vesicles which contain high amounts of calcium and phosphate ions. Ossification of new bone by osteoblasts occurs by appositional growth
Osteocyte
Once an osteoblast has secreted enough bone matrix to become surrounded by it, it is referred to as an osteocyte. Mature bone cell formed from osteoblasts. Retain their connections to neighboring osteocytes through their cell extensions. An osteocyte occupies the space without matrix (lacunae)
Osteoclast
Massive, multi-nucleated, bone-destroying cells. Made of about 50 monocytes fused. Perform resorption of bone that mobilizes calcium and phosphate ions used in metabolic processes.
Bone matrix
The intercellular substance of the bone tissue; comprised of organic (collagen and proteoglycans) and inorganic substances (mainly hydroxyapatite). Gives bone tensile strength and weight bearing strength
Ruffled border
The osteoclast cell membrane differentiates into the ruffled border after coming in contact with the bone surface. Specialized reabsorption-specific area of the membrane where acidic vesicles fuse into.
Lacunae
Spaces without matrix occupied by the osteocyte cell body
Canaliculi
Spaces occupied by osteocyte cell extensions. The extensions form a mold around which the matrix is formed and the extensions of osteocytes are in contact with one another through the canaliculi. Filled with extracellular fluid and lead to the lacunae
Woven bone
As bone formation progresses, the newly formed bone goes through several stages. First type of bone that osteoblasts form during ossification. Fairly weak and the collagen fibers are randomly orientated in many directions
Bone remodeling
Process of removing old bone and adding new bone
Lamellar bone
Mature bone that is organized into thin, concentric layers approximately 3-9 micrometers thick. Collagen fibers of one lamella lie parallel to one another, but at an angle to the collagen fibers in the adjacent lamellae. Osteocytes, within their lacunae are arranged in layers sandwiched between the lamellae
How can bone be classified?
According to the amount of bone matrix relative to the amount of space within the bone
Spongy/Trabecular/Cancellous bone
Appears porous, has less bone matrix, has more space than compact bone. Appears porous, consists of trabeculae. Between the trabeculae are spaces that are eventually filled in with bone marrow and blood vessels
Trabeculae
Interconnecting rods/plates of bone. Oriented along the lines of mechanical stress within a bone. If the force on a bone is changed slightly, the trabeculae pattern realigns with the new lines of stress
Compact/Cortical bone
More matrix and less space than spongy bone. compact and dense. Blood vessels enter the substance of the bone itself and the lamellae are primarily oriented around those blood vessels
Osteon/Haversian system
Functional unit of a long bone, composed of concentric rings of matrix which surround the central canal and contain osteocytes
Central canal
4-20 concentric lamellae form the rings. Vessels run parallel to the long axis of the bone and are contained here. Lined with endosperm and contain blood vessels, nerves, loose connective tissue
Volkmann/Perforating/Transverse canal
Inside osteons, run perpendicular, connect adjacent osteons. Blood vessels from the periosteum or medullary cavity enter the bone through Volkmann canals. Are not surround by concentric lamellae, but pass through the concentric lamellae of osteons. Central canals receive blood vessels from Volkmann canals
Central/Haversian canal
Tiny longitudinal canals in bone tissue, averaging about 0.05 mm in diameter. Each contains blood vessels, connective tissue, nerve filaments, and occasionally lymphatic vessels. The canals are interconnected and part of an intricate network
Lamella
A thin layer, membrane, scale, or platelike tissue or part, especially in bone tissue
What are the 3 types of lamellae?
Concentric, circumferential, and interstitial lamellae
Concentric lamellae
Circular layers of bone matrix that surround the central canal
Circumferential lamellae
Form the outer surface of compact bone. Thin plates that extend around the bone
Interstitial lamellae
Remnants of concentric or circumferential lamellae that were partially removed during bone remodeling
Periosteum
Double layered connective tissue membrane covering the outer surface of the bone except where articular cartilage is present. Ligaments and tendons attach to bone through the periosteum. Blood vessels & nerves from the periosteum supply the bone. This is also where the bone grows in diameter
Endosteum
Connective tissue membrane lining the inner bone cavities
Diaphysis
Shaft of long bone. The primary center of ossification is in here
Epiphyseal plate/Growth plate
Area of hyaline cartilage between the diaphysis and epiphysis. Cartilage growth occurs here, followed by endochondrial ossification which results in growth in length