Exam II Flashcards
Functions of skin
Protection, sensation, temperature regulation, vitamin D production, excretion
Epidermis
Superficial layer, stratified squamous epithelial tissue. Reduces water loss and resists abrasion
Papillary Layer
Uppermost layer of the dermis. It intertwines with the rete ridges of the epidermis and is composed of fine and loosely arranged collagen fibers. Composed of loose areolar connective tissue. ontains blood vessels that Supplies the overlying epidermis with oxygen and nutrients, remove waste products, and aid in regulating body temperature
Dermis
Underneath the epidermis, layer of connective tissue, strength of the skin
Hypodermis/Subcutaneous tissue
Layer of loose connective tissue deep to the dermis that connects skin to underlying bone or muscle. Not a part of the integumentary system
Avascular layer
Epidermis
Langerhans cells
Part of the immune system and function in immune responses
Dermal papillae
Small, nipple-like extensions of the dermis into the epidermis. At the surface of the skin in hands and feet, they appear as epidermal or papillary ridges (fingerprints)
Keratinocytes
Most abundant in the skin and produces the protein mixture keratin which makes cells more durable and waterproof
Keratinization
Movement of keratinocytes from the deepest layer of the epidermis to the surface. As the move to the surface, keratinocytes chase shape and chemical composition. Eventually, they reach the epidermis and slough off
Where the keratinocytes fill up with the protein keratin and in so doing cause both the cell’s nucleus and organelles to disintegrate and the cell starts to die; not complete until the cells reach the more superficial epidermal layers; a fully keratinized cell is dead (no nucleus or organelles) but it is structurally strong because of the keratin it contains
Where does mitosis occur in the skin?
Mitosis occurs exclusively at the basal cell layer and allows for the replacement of cells lost from the surface
Order of epidermal strata from deepest to most superficial
Stratum basale (germinative), stratum spinosum, stratum granulosum, stratum lucid, stratum corneum
Stratum basale
Deepest layer of the epidermis. Single layer of cuboidal or columnar cells. Keratinocytes stem cells undergo mitotic division. Epidermis is anchored to the basement membrane by hemidesmosomes
Stratum spinosum
8-10 layers of many sided cells. As cells are pushed to the surface, they flatten and desmosomes break apart & form new ones. Cells shrink except where they’re attached to desmosomes which make they appear spiny. Keratin fibers and lamellar bodies form inside the keratinocytes
Stratum granulosum
2-5 layers of slightly flattened, diamond-shaped cells. Long axes of these cells are parallel to the surface of the skin. Presence of protein granules (keratohyalin) which accumulate in cytoplasm of cells.
Stratum Lucidum
Thin, clear zone above the stratum granulosum. Several layers of dead cells with distinct boundaries. Keratin fibers are present but keratohyalin has dispersed. Cells appear slightly transparent. Only present in thick skin
Stratum corneum
Most superficial start of the epidermis. 25+ layers of dead, overlapping squamous cells joined by desmosomes. Cells have hard envelopes filled with keratin (cornfield cells)
Soft keratin
Found in the skin
Hard keratin
Found in nails and external parts of the hair
How is skin classified? (thin or thick)
Classified based on the structure of the epidermis
Thick skin
Has 5 strata, stratum corner has many layers. Includes the stratum lucidum and is found on palms, soles of feet, and fingertips
Thin skin
More flexible, has hair, each strata contains fewer lays of cells than in thick skin. Stratum granulosum frequently consists of only 1-2 layers of cells and the stratum lucid is generally absent
Melanocyte
Irregularly shaped cells with many long processes that extend between the keratinocytes of the stratum basale and the stratum spinosum. Melanocytes produce and package melanin into vesicles called melanosomes, which move into cell processes of the melanocytes and contributes to skin color
Cyanosis
A decrease in blood flow, makes the skin appear pale. A decrease in the blood oxygen content produces cyanosis
Carotene
Yellow pigment found in plants such as corn and carrots. Lipid soluble. Excess amounts can accumulate in the stratum corner and in the adipocytes of the dermis/hypodermis and gives the skin a yellowish tint