Exam 7 - Oz Male First 63 cards Flashcards

1
Q

Production of offspring by making germ cells called gametes

A

Sexual Reproduction

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2
Q

Male gamete (sperm cell) unites with female gamete (secondary oocyte)

A

Fertilization

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3
Q

This produces one cell containing one set of chromosomes from each parent

A

Fertilization

Male gamete (sperm cell) unites with female gamete (secondary oocyte)

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4
Q

Produce gametes and secrete sex hormones

A

Gonads

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5
Q

Store and transport gametes

A

Ducts

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6
Q

Produce substances to protect the gamete and facilitate their movement

A

Accessory Sex Glands

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7
Q

Supporting Structures

Penis and Uterus assist delivery of ____

Uterus provides site for growth of….

A

gametes

…embryo and fetus

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8
Q

Gynecology

A

Branch of medicine concerned with the diagnosis and treatment of diseases of the female reproductive system

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9
Q

Study of the urinary system

Urologists also diagnose and treat diseases and disorders of male reproductive system

A

Urology

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10
Q

Andrology

A

Branch of medicine concerned with male disorders to include infertility and sexual dysfunction

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11
Q
  • produce sperm and secrete hormones
A

Testes

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12
Q
  • transports and stores sperm, assists in their maturation, conveys them to the exterior
A

Ducts

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13
Q

Epididymis
Ductus deferens (Vas deferens)
Ejaculatory ducts
Urethra

A

Ducts

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14
Q

Ductus deferens AKA

A

(Vas deferens)

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15
Q
  • provides secretions to semen
  • –Seminal vesicles
  • –Prostate
  • –Bulbourethral glands
A

Accessory Sex Glands

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16
Q
  • supports the testes

- delivers sperm into the female reproductive tract

A

Supporting Structures

Scrotum

Penis

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17
Q

Devoid of fat

Numerous sebaceous and sweat glands

A

Loose skin

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18
Q

Externally, the skin of the scrotum is one single pouch

A

Raphe (external ridge, fold of tissue, not a true septum)

Extends from urethral meatus, down the ventral shaft, scrotum and ends at the anus

Represents the fusion of the genital tubercles (embryonic development)

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19
Q

(external ridge, fold of tissue, not a true septum)

A

Raphe

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20
Q

Scrotum

Raphe

Extends from ____, down the ventral shaft, scrotum and ends at the anus

A

urethral meatus

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21
Q

Scrotum

Raphe

Represents the fusion of the…

A

…genital tubercles (embryonic development)

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22
Q

Scrotum:

  • Skin
  • Subcutaneous layer (derived from abdominal structures during embryonic development)
A

True

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23
Q

(derived from abdominal structures during embryonic development)

A

Subcutaneous layer

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24
Q

Subcutaneous layer

A

Dartos muscle (smooth muscle)

External spermatic fascia

Cremaster muscle (skeletal muscle)

Internal spermatic fascia

Tunica vaginalis (parietal layer)

Tunica vaginalis (visceral layer)

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25
Q

Dartos muscle (type?)

A

(smooth muscle)

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26
Q

Cremaster muscle (type?)

A

(skeletal muscle)

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27
Q

Tunica vaginalis (type?)

A

(parietal layer)

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28
Q

Tunica vaginalis (two types of layers)

A

(parietal layer)

(visceral layer)

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29
Q

slide 17… great pic of the scrotum layers

A

take a look at that sweet meat

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30
Q

Scrotum

Internally divided into two sacs by

Each sac contains…

A

scrotal septum

…single testis

SLIDE 18

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31
Q

Regulation of temperature of the testes

Normal sperm production requires temperatures….

Lower temperature maintained in the scrotum because it is…

A

….slightly below core body temperature

….outside the pelvic cavity

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32
Q

Muscles contract in colder temperatures to preserve heat

What is cremaster?

How about dartos?

A

Cremaster- contraction moves testes closer to body to absorb more heat

Dartos- causes scrotum to become tighter (more wrinkled) which reduces heat loss

**Exposure to warmth reverses this process

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33
Q

check out slide 20 to see the cremaster and dartos contracted vs relaxed

A

if you’re into that sort of thing

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34
Q

Testis- singular

Testes/testicles- plural

Paired oval glands

Measure about 2 inches long and 1 inch in diameter

Develop near the…. and then do what in 7th month of fetal development?

A

kidneys, descend through the inguinal canal in the 7th month of fetal development

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35
Q

Considered part of the scrotum as well as part of the testicles

A

Tunica vaginalis

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36
Q

Inner most layer of the scrotum

Outer most layer of the testicle

A

Tunica vaginalis

Considered part of the scrotum as well as part of the testicles

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37
Q

Forms from the peritoneum during descent of testes?

A

Tunica vaginalis:

Parietal layer
Visceral layer

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38
Q

Cavity formed between the two layers which holds small amount of lubricating fluid

A

Tunica vaginalis

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39
Q

If you place a flashlight directly on the skin, it will shine through if it’s fluid filled

If it does not shine through, its likely solid

A

Transillumination

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40
Q

Internal to the tunica vaginalis layer

White fibrous dense tissue

Extends inward to form septa that divide the testis into lobules
—Think of a hard boiled egg

A

Tunica albuginea

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41
Q

Functional unit of the testicles

Each testis contains 200-300

Made up of seminiferous tubules (1-3 in each lobule)

A

Lobules

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42
Q

slide 25 has a sweet picture

A

nuts

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43
Q

Seminiferous Tubules

Contain two types of cells?

A

Spermatogenic cells- sperm forming cells

Sertoli (sustentacular) cells- supports spermatogenesis

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44
Q
  • sperm forming cells
A

Spermatogenic cells

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45
Q
  • supports spermatogenesis
A

Sertoli (sustentacular) cells

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46
Q

Location of spermatogenesis

Begins with primordial germ cells during fetal development which then differentiate into…

Spermatogonia

A

Seminiferous Tubules

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47
Q

Enter the testes during 5th week of embryonic development

These remain dormant until puberty and then when activated, aid in production of sperm

A

Spermatogonia

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48
Q

Seminiferous Tubules

In order of advancing maturity (young to old)

A

Spermatogonia - Primary spermatocyte - Secondary spermatocyte - Spermatid - Sperm cell (spermatozoa)

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49
Q

Seminiferous Tubules:

Sertoli cells AKA

A

(sustentacular cells)

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50
Q

Embedded amongst the spermatogenic cells

Extend from the basement membrane to lumen of tubule

Support and protect spermatogenic cells

A

Sertoli cells (sustentacular cells)

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51
Q

Nourish spermatocytes, spermatids, sperm

Phagocytize excess spermatid cytoplasm

Controls release of sperm into lumen

Produces fluid for sperm transport INSIDE the tubules

Produces androgen binding protein (ABG) which has effects of testosterone

A

Sertoli cells (sustentacular cells)

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52
Q

Sertoli cells (sustentacular cells)

How do they Support and protect spermatogenic cells?

A

Nourish spermatocytes, spermatids, sperm

Phagocytize excess spermatid cytoplasm

Controls release of sperm into lumen

Produces fluid for sperm transport INSIDE the tubules

Produces androgen binding protein (ABG) which has effects of testosterone

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53
Q

Seminiferous Tubules:

Tight junctions formed by Sertoli cells

Isolates developing gametes from blood

A

Blood-Testis barrier

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54
Q

Seminiferous Tubules:

Prevents an immune response to spermatogenic cell’s surface antigens

These antigens are recognized as “foreign” by the immune system

A

Blood-Testis barrier:

Tight junctions formed by Sertoli cells

Isolates developing gametes from blood

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55
Q

Seminiferous Tubules:

Located in the tunica albuginea surrounding the seminiferous tubules

Produces and secretes testosterone

A

Leydig Cells

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56
Q

Produces and secretes testosterone

  • –Development of masculine characteristics
  • –Promotes male sex drive
A

Leydig Cells

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57
Q

Seminiferous Tubules

on slide 29 and 30

A

Seminiferous Tubules

on slide 29 / 30

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58
Q

Takes 65-75 days

A

Spermatogenesis

59
Q

Contains diploid (2n) number of chromosomes (46)

Under the influence of testosterone, these undergo mitosis (at puberty)

A

Spermatogonia

60
Q

Some spermatogonia remain near the basement membrane and act as reservoir of cells for future sperm production

Others lose contact with basement membrane, squeeze through blood-testis barrier and undergo development

Differentiate into primary spermatocytes

A

Spermatogonia:

Under the influence of testosterone, these undergo mitosis (at puberty)

61
Q

Differentiate into primary spermatocytes

A

Spermatogonia

in Spermatogenesis

62
Q

Contains diploid (2n) number of chromosomes (46)

Starts to replicate its own DNA

Meiosis 1 begins at this point

A

Primary Spermatocytes

of Spermatogenesis

63
Q

Homologous pairs of chromosomes line up at metaphase plate where cross-over occurs

Meiotic spindle pulls one (duplicated) chromosome of each pair apart and pulls it to opposite poles of dividing cell

Two cells formed from Meiosis 1 called secondary spermatocytes

A

Primary Spermatocytes within spermatogenesis and the beginning of meiosis 1

64
Q

Each cell is now haploid (n), contains 23 chromosomes

Each chromosome is made up of two chromatids (two copies of DNA) still attached by a centromere

Meiosis 2 occurs at this point

A

Secondary spermatocytes within Spermatogenesis

65
Q

Meiosis 2 occurs at this point

Chromosomes line up at metaphase plate where the two chromatids of each chromosome separate

Four (4) haploid cells (23 chromosomes) are produced called spermatids

A

Secondary spermatocytes within Spermatogenesis

66
Q

Spermatogenesis:

A single primary spermatocyte produces four spermatids via two rounds of cell division

A

meiosis 1 & 2

67
Q

2n- Diploid- 46 chromosomes

2n- Diploid- 46 chromosomes

n- Haploid- 23 chromosomes

n- Haploid- 23 chromosomes

n- Haploid- 23 chromosomes

A

spermatogenesis

68
Q

– Final stage of spermatogenesis

A

Spermiogenesis

69
Q

Development of haploid spermatids into sperm

One spermatid develops into one sperm

Spherical spermatids start to elongate

A

Spermiogenesis – Final stage of spermatogenesis

70
Q

An acrosome forms atop the nucleus

A flagellum develops

Mitochondria multiply

Sertoli cells dispose of excess cytoplasm (if any)

A

Spherical spermatids start to elongate within SPERMIOGENESIS

71
Q
  • sperm being released from their connection to Sertoli cells into the lumen
A

Spermiation

72
Q

Sperm CANNOT swim at this point

A

Fluid from Sertoli cells help the sperm travel to the ducts of the testes

73
Q

sperm pick on slide 36

A

36

74
Q

Each day approximately 300 million sperm complete spermatogenesis
—–Once ejaculated, can last up to 48 hours in female reproductive tract

A

Sperm

75
Q

Cap-like vesicle filled with enzymes that help the sperm penetrate the secondary oocyte
—Enzymes include hyaluronidase and proteases

A

Acrosome

Sperm

76
Q

—Enzymes include hyaluronidase and proteases

A

Acrosome

77
Q

Sperm:

Tail
Divided into 4 parts

A

Neck- contains centrioles

Middle piece- contains mitochondria (energy for movement)

Principal piece- longest portion of tail

End piece- terminal tapering piece of tail

78
Q

Hormonal Control of Testes

Male Reproductive Cycle

At puberty, ____ increases

A

At puberty, GnRH increases

79
Q

produces androgen binding protein?

A

seminiferous tubules but in particular the SERTOLI CELLS (SUSTENTACULAR CELLS)

80
Q

produces androgen binding protein?

A

seminiferous tubules but in particular the SERTOLI CELLS (SUSTENTACULAR CELLS)

81
Q

produces and secretes testosterone?

A

Leydig cells (still need ABG to keep it loca FROM HER IN LECTURE DOUBLE CHECKl)

82
Q

At puberty, GnRH increases

This stimulates ___ to secrete what?

A

gonadotrophs (Ant. Pit.) to secrete luteinizing hormone (LH) and follicle stimulating hormone (FSH)

83
Q

Stimulates leydig cells to produce/secrete testosterone

A

LH

84
Q

Synthesized from cholesterol in the testes

A

testosterone produced by Leydig cells (stimulated by LH)

85
Q

Makes testosterone lipid-soluble which allows diffusion out of leydig cells, through interstitial fluid and into

  • –Blood
  • –Seminiferous tubules
A

The cholesterol makes it lipid soluble (produced by leydig cels and stimulated by LH)

86
Q

5-alpha-reductase can convert some testosterone (in external genitals and prostate) into another androgen called

A

DHT (dihydrotestosterone)

87
Q

DHT (dihydrotestosterone)

A

Much more potent androgen

Thought to “spark” puberty in males

Thought to combine with testosterone to account for male sexual behavior/desire

Responsible for male external organs in fetal development

88
Q

The diploid cells AKA ____ are differentiated during what process, and what is formed from them?

A

meiosis I occurs to diploid (2n) AKA primary spermatocytes to form

secondary spermatocytes… which are now called haploid (n)

89
Q

Much more potent androgen

Thought to “spark” puberty in males

Thought to combine with testosterone to account for male sexual behavior/desire

Responsible for male external organs in fetal development

A

DHT (dihydrotestosterone)

90
Q

Hormonal Control of Testes

Some testosterone gets sent into systemic circulation

The majority of testosterone stays in the testes to ____

This is only accomplished by….

A

promote spermatogenesis

….androgen binding protein (ABG) being present to keep testosterone in this location

ABG is made in the Sertoli Cells

91
Q

ABG is made in the

A

Sertoli Cells

92
Q

Acts indirectly to stimulate spermatogenesis

Works synergistically with testosterone to act on the

Sertoli cells to secrete Androgen-binding protein (ABP)

ABP binds to testosterone in the tubule lumen which keeps a high concentration of testosterone in the area

Testosterone stimulates the final steps of spermatogenesis

A

FSH

93
Q

Testosterone stimulates the final steps of spermatogenesis

A

Once normal level of spermatogenesis occurs, Sertoli cells release small amounts of inhibin

Reduces the production of FSH

94
Q

LH is very important in males

A

said in lecture… so pay attention to those slides

95
Q

Effects of Testosterone and DHT

Prenatal development
Testosterone stimulates development…

A

of male reproductive system ducts and descent of testes

96
Q

FSH plays a much larger role in?

A

females according to lecture

97
Q

Effects of Testosterone and DHT

DHT stimulates development of

A

external genitals

98
Q

Effects of Testosterone and DHT

Converted in the brain to _____, which is thought to help develop certain brain regions

A

estrogens

99
Q

Effects of Testosterone and DHT

Male sexual characteristics
—-At puberty development and enlargement of male sex organs and masculine secondary sex characteristics

A

Traits that distinguish males and females, but do not play a role in reproduction

Include muscular/skeletal growth (wide shoulders, narrow hips,) facial and chest hair, thickening of skin, increased sebaceous gland secretion, enlargement of larynx (deeper voice)

100
Q

Effects of Testosterone and DHT

Development of Sexual Function (3 mentioned)?

A

Contributes to male sexual behavior, spermatogenesis

Contributes to sex drive in BOTH males and females

Adrenal cortex in females is the main source of androgen production

101
Q

in females is the main source of androgen production

A

Adrenal cortex

102
Q

Effects of Testosterone and DHT

Stimulation of Anabolism:

Stimulates ____

Obvious in heavier muscle and bone mass in most males as compared to women

A

protein synthesis

103
Q

Reproductive System Ducts

In Males

Ducts of the Testis?

A

Straight tubules

Rete testis

Efferent ducts

Ductus epididymis

Epididymis (1 per testis)

Ductus Deferens (Vas Deferens)

104
Q

Pressure generated by fluid secreted by Sertoli cells pushes the sperm and fluid through seminiferous tubules and then into these

A

Straight tubules

105
Q

Found at the hilum of the testicle

A network of ducts that bridge the straight tubules and efferent ducts

A

Rete testis

106
Q

Coiled ducts in the epididymis

Leads to the ductus epididymis

A

Efferent ducts

107
Q

Ducts of the Testis

A single convoluted tube connecting the efferent ducts and the ductus deferens (vas deferens)

Would measure approximately 20ft in length if uncoiled

A

Ductus epididymis

108
Q

Ducts of the Testis

Contains mostly tightly coiled ductus epididymis
Comma shaped organ about 1.5in long

Lies at the posterior aspect of each testis

Site of sperm maturation

Helps propel sperm into ductus deferens during sexual arousal

Stores sperm for up to several months

Any stored sperm that is not ejaculated within it’s lifecycle is reabsorbed

A

Epididymis (1 per testis)

109
Q

slide 47 shows some ducts of the testis

A

slide 47

110
Q

Ductus (Vas) Deferens

A

slid 50

111
Q

Ductus Deferens AKA

A

(Vas Deferens)

112
Q

Known as ductus deferens at this point

A

Within the epididymis, the tubule becomes less convoluted and it’s diameter increases

113
Q

Traverses through the spermatic cord, enters the pelvic cavity, loops over the ureter where it enters the bladder and runs down the posterior surface

A

Ductus Deferens (Vas Deferens)

114
Q

Right side drains directly into the inferior vena cava

Left side drains into the left renal vein

Because of this difference, much more pathology is usually found on the left side

A

Pampiniform Plexus

Ascends anterior to the vas deferens on both sides

Tortuous network of veins that drains the scrotum and the testicles

115
Q

Spermatic Cord

Supporting structure, ascends out of the scrotum

Consists of?

A
Ductus (vas) deferens
Testicular artery
Veins
Carry testosterone into circulation (via pampiniform plexus)
Lymphatic vessels
Autonomic nerves
Cremaster muscle
116
Q

____ with the ilioinguinal nerve pass through the inguinal canal (passage into abdominal cavity)

A

Spermatic cord

117
Q

Ascends anterior to the vas deferens on both sides

Tortuous network of veins that drains the scrotum and the testicles

A

Pampiniform Plexus

Spermatic Cord– Venous Drainage

118
Q

____ side drains directly into the inferior vena cava

A

Right

Spermatic Cord– Venous Drainage

119
Q

___ side drains into the left renal vein

Because of this difference, much more pathology is usually found on the left side

A

Left

Spermatic Cord– Venous Drainage

120
Q

Ejaculatory Duct

Formed by the union of the…

A

seminal vesicle and the ampulla of the ductus (vas) deferens

121
Q

Ejaculatory Duct

Terminates at the…

Ejects sperm and seminal vesicle secretions

A

…prostatic urethra

122
Q

A shared terminal duct

  • Reproductive system
  • Urinary system
A

Male Urethra

123
Q

Approximately 8 inches long (internal and external)

A

Male Urethra

124
Q

Passes through the prostate, deep muscles of the perineum, and then the penis

A

Male Urethra

125
Q

Male Urethra

Subdivided in three sections:

A

Prostatic urethra- 1 inch long

Membranous urethra- 0.5 inch long

Spongy (penile) urethra- 6-8 inches long

126
Q

Ends at external urethral orifice

A

Male Urethra

127
Q

Male Urethra ends at?

A

external urethral orifice

128
Q

slide 56 male urethra

A

slide 56 male urethra

129
Q

Accessory Sex Glands
in Males

Secretes most of the ___ portion of semen

Small portion of fluid comes from the …..

A

fluid

….seminiferous tubules with sperm (1% of fluid in semen)

130
Q

Includes
Seminal vesicle secretion- 60% of fluid in semen

Prostatatic secretion- 25% of fluid in semen

Bulbourethral gland secretion- 14% of fluid in semen

A

Accessory Sex Glands

THIS SLIDE MAY HAVE DOWNLOADED INCORRECTLY…. LOOK IF THERE IS A DIFFERENT NAME OTHER THAN “ACCESSORY”

131
Q

slide 59

A

slide 59

132
Q

Paired set of convoluted pouch-like structures

Usually 2 inches in length

A

Seminal Vesicles

133
Q

Seminal vesicle secretions

acidic or alkaline?

A

Alkaline

Helps to neutralize acidic environment of male urethra and female reproductive tract (these would kill sperm)

134
Q

Seminal vesicle secretions

viscous or thin?

A

Viscous

Helps to keep semen in female reproductive tract longer to increase chances of fertilization

135
Q

Seminal vesicle secretions contain

A

Fructose
used for ATP production by sperm

Prostaglandins
Contributes to sperm motility and viability
Thought to stimulate smooth muscle contraction within female reproductive tract (help move sperm towards ova)

Clotting proteins
Helps semen coagulate after ejaculation (helps semen stay in female reproductive tract longer)

136
Q

Single, walnut/doughnut shaped gland

Approximate size of a golf ball

Inferior to bladder

Surrounds prostatic urethra

Grows slowly in size from birth to puberty

At puberty grows rapidly until age 30 then remains stable until age 45 when further enlargement may occur

A

Prostate

137
Q

Prostate

location and surrounds?

A

Inferior to bladder

Surrounds prostatic urethra

138
Q

Secretes prostatic fluid

Component of semen

A

Prostate

139
Q
Milky fluid
Slightly acidic (pH of 6.5)
A

Prostatic fluid

140
Q

Prostatic fluid

contains?

A

1) Citric acid- used for ATP production

2) Proteolytic enzymes- help break down clotting factors in seminal vesicle fluid (PPHAL)
- -Prostate specific antigen
- -Pepsinogen
- -Hyaluronidase
- -Amylase
- -Lysozyme

3) Seminalplasmin- decrease number of bacteria in semen

141
Q

citric acid in prostatic fluid for?

A

Citric acid- used for ATP production

142
Q

Proteolytic enzymes in prostatic fluid for?

A

Proteolytic enzymes- help break down clotting factors in seminal vesicle fluid (PPHAL)

  • -Prostate specific antigen
  • -Pepsinogen
  • -Hyaluronidase
  • -Amylase
  • -Lysozyme
143
Q

Seminalplasmin in prostatic fluid for?

A

Seminalplasmin- decrease number of bacteria in semen