Exam 7 Female slides #1-50 Flashcards
Ovaries
Fallopian tubes (uterine tubes, oviducts)
Uterus
Vagina
External organs
Collectively called the vulva or pudendum
*mammary glands are considered part of both the integumentary and reproductive systems
Included in Female reproductive system
External female reproductive collectively called:
Collectively called the vulva or pudendum
____ glands are considered part of both the integumentary and reproductive systems
Mammary
female gonads resemeble:
Resemble unshelled almonds in size and shape
Female gonads produce:
Produce gametes
Secondary oocytes that develop into mature ova after fertilization
Hormones of the female gonads:
Progesterone
Inhibin
Estrogen
Relaxin
PIER
Ovaries:
On either side of uterus
Held in place by: (3)
Broad ligament- fold of parietal peritoneum
Ovarian ligament- anchors ovaries to uterus
Suspensory ligament- attaches them to pelvic wall
Each ovary contains a ____
Point of entrance or exit for blood vessels and nerves
Hilum (hilus)
Covers surface of ovary
Germinal epithelium
white capsule of dense irregular connective tissue deep to the germinal epithelium
Tunica albuginea
Deep to tunica albuginea, consists of ovarian follicles which are surrounded by dense connective tissue layer that contains collagen fibers and fibroblast-like cells called stromal cells
Ovarian cortex
Deep to the ovarian cortex, consists of more loosely arranged connective tissue which contains blood vessels, lymphatic vessels, and nerves
Ovarian medulla
Lie in the cortex, consist of oocytes in various stages of development plus the cells surrounding them
Ovarian follicles
(cells that surround follicles)
Granulosa cells
Begin with cells in single layer awaiting oogenesis
Example:
Example: primordial follicle
Under the influence of FSH, cells multiple into layers
Example:
primary and secondary follicles
see it, know it!
slide 8 among others
Large, fluid filled follicle that is ready to rupture
Expels the secondary oocyte (process of ovulation)
Mature (graafian) follicle
Contains remnants of mature follicle after ovulation
Produces progesterone, estrogens, relaxin and inhibin until it degenerates
Corpus luteum (yellow body)
Degenerates into scar tissue called
corpus albicans
Formation of gametes in ovaries
Oogenesis
Begins in females before birth
Remember spermatogenesis begins in males at puberty
Oogenesis
____occurs in essentially same manner as spermatogenesis
Mitosis takes place (this is NOT continual in females like it is in males)
Meiosis takes place
Resulting germ cells undergo maturation
Oogenesis
~4th week of fetal development, primordial germ cells migrate from yolk sac to _____
Gonadal ridge
At the gonadal ridge, they are now called _____ (immature germ cells)
Oogonia
Oogonia are ___ __ stem cells that undergo mitosis to produce 6-7 million oogonia by mid-gestational period (20 weeks)
diploid (2n)
These oogonia are then stimulated to begin meiosis I which then changes their classification into ___ ___
Primary oocytes
Primary oocytes
Become “____” in the prophase of meiosis I until puberty
arrested
During this arrested phase, the primary oocyte is surrounded by a single layer of granulosa cells
Entire structure at this point is called a __ __
primordial follicle
Mid-gestation, a female will have generated all of the ___ ___ she will ever be able to
Primordial follicles
Many of these will die by ____ over the course of the next 40-50 years
Unlike male gametes, females cannot produce more oogonia to start the process over
apoptosis
Slide 14
know this too!
~7 million oogonia at mid-gestation
~1 million primordial follicles at birth
~300,000 primordial follicles at puberty
’s
400 will mature and be ___ during a woman’s reproductive lifetime
What is significant about 400?
ovulated
Anywhere from 5,000-15,000 per month are lost due to ___ (degeneration) or apoptosis (programmed cell death)
atresia
Each month after puberty until menopause
___/__ stimulate development of 10-30 primordial follicles
Normally only one will reach maturity needed for ovulation
FSH/LH
These primordial follicles morph into ____
primary follicles
The single layer of granulosa cells begins to proliferate leaving multiple layers of granulosa cells surrounding the primary oocyte
These granulosa cells start to produce small amounts of ___-containing fluid that starts to fill inside the follicle
estrogen
stromal cells surrounding basement membrane
Theca folliculi-
pic!
slide 17
continued maturation turns primary follicles into these
Secondary follicle-
highly vascularized cells, secretes precursor androgen that granulosa cells convert into estrogen
Theca interna-
outer layer of stromal cells and collagen fibers
Theca externa-
these cells Continue to secrete estrogen-containing fluid that builds up in a cavity called the antrum (in center of secondary follicle)
Granulosa cells
Innermost layer of granulosa cells converts into cumulus-granulosa cells, which attach to the oocyte
Corona radiata
These cumulus-granulosa cells produce/secrete small amounts of ____ which is thought to attract sperm and promote motility
Progestrone
As the oocyte develops, it secretes a gel-like matrix that coats itself
Helps to adhere the cumulus-granulosa cells to it
This process begins in primary follicles but completes as secondary follicles
Zona pellucida
pay attention to antrum on this slide..
slide 20
Just before ovulation of the mature follicle
The diploid primary oocyte completes meiosis I
This produces two haploid (n) cells of UNEQUAL size
Each has ## chromosomes
23
The smaller haploid cell is called the __ __ __
Packet of discarded nuclear material
Either degenerates or divides to form non-functional cells
First polar body
The larger haploid cell is now called the secondary oocyte
Receives most of the cytoplasm
Begins meiosis II but stops in ____
Is then released (ovulation)
Metaphase
Secondary OOCYTE expelled into pelvic cavity
Also expelled is the first polar body
Normally all is “swept” into the ___ __
fallopian tubes
If fertilization does not occur, all cells ____
degenerate
If sperm present and penetrates secondary oocyte, meiosis II resumes
Secondary oocyte splits into ## ___
2 haploid cells
Ovum- larger cell (+ nuclei of sperm = ___ ___)
Second polar body- smaller, leftovers
diploid zygote
Oogenesis and development of follicle
slide 23
After ovulation
Currents produced by fimbriae surround mature follicle (just released from ovary)
This current pulls the ___ from the peritoneal cavity into the fallopian tube
Oocyte
Peristaltic movements of tubal layers move the secondary oocyte toward the ___
If not fertilized at time of uterus arrival, the oocyte will begin to disintegrate (menses)
Uterus
Fertilization
Sperm cell usually encounters secondary oocyte in the ___ of fallopian tube (fertilization)
Can happen in the peritoneal cavity but this is rare
ampulla
Haploid(n) nuclear materials unite Becomes diploid (2n) (now called a \_\_\_)
Zygote
Begins cell division while moving towards uterus
Arrives at uterus 6-7 days after ovulation
Implantation occurs in ___ __
uterine wall
Fallopian tube
slide 26
Uterus: position is superior to the bladder
_____- body of uterus projects anteriorly over bladder (normal position
Anterior to the rectum
Anteflexion
Part of the pathway for sperm deposited in the vagina to reach the uterine tube
Site of implantation of the fertilized ovum, development of the fetus during pregnancy/labor
If implantation does not occur, uterus is source of ___ ___
menstraul flow
Uterus
slide 29-31
top of the uterus
Fundus
central portion of uterus
body
inferior extension of uterus into vaginal canal
Cervix
region between the body and the cervix
Isthmus
Uterus:
interior of the body
Uterine cavity
Uterus:
interior of the cervix
Cervical canal
- opening of the canal into the uterus
Internal os
- opening of the canal into the vagina
External os
Three histological layers (external to internal)
Perimetrium
Myometrium
Endometrium
Laterally becomes broad ligament
Anteriorly covers bladder, forms vesicouterine pouch
Posteriorly covers rectum, forms rectouterine pouch
This is the inferior most location in the abdominal cavity
Tends to be where fluid collects
Perimetrium
consisting of three layers of smooth muscle
Myometrium
Stratum functionalis layer- shed each month during menstruation
Stratum basalis layer- permanent, gives rise to a new stratum functionalis after each menstruation
Endometrium
Perimetrium pouches
slide 34
Rectouterin is in red…
also vesicouterine
Uterus pic
slide 35
double folds of peritoneum
Attached uterus to either side of pelvic cavity
Broad Ligaments
peritoneal extensions
Lie on either side of rectum
Connect uterus to sacrum
Uterosacral Ligaments
Inferior to base of broad ligaments
Extend from pelvic wall to cervix and vagina
Cardinal (lateral) Ligaments
fibrous connective tissue between broad ligaments
Extend from point on uterus just inferior to fallopian tubes to portion of labia majora (external genitalia)
Round Ligaments-
Uterine Ligaments
slide 37
branches of internal iliac artery
Supply blood to the uterus
Uterine arteries
branches from uterine arteries
Arranged in circular fashion in myometrium
Acruate arteries
branches of arcuate arteries
Penetrate deeply into myometrium
Just before these enter endometrium they branch
Radial arteries
supply stratum basalis
Straight arterioles
supply stratum functionalis*
Spiral arterioles
Uterine Veins- blood leaving uterus empties into __ __ veins
Internal iliac
Uterine blood supply
slide 39
Most inferior portion of uterus
Extends into vaginal canal
Cervix
Encompassing external cervix and os
Usually 1 inch in diameter
Ectocervix
Encompasses endocervical canal to internal os
Endocervix
produced by secretory cells of cervix
chemically more hospitable to sperm during ovulation because it is less viscous and more alkaline
Cervical Mucus
Cervix
slide 41
Never had fetus pass through cervix
Could mean someone who had a c-section though
Nulliparous
Had child pass through cervix
Parous
Histology of cervix
best understood through the slide #43-46
Tubular, 4 inch long fibromuscular canal
Lined with a mucous membrane that extends from exterior of body to cervix
Vagina
Outlet for menstrual flow
Passageway for birth
Vagina
Recess that surrounds vaginal attachment to cervix
Fornix
anchors vagina to adjacent organs
Adventitia
composed of an outer circular layer and inner longitudinal layer of smooth muscle
This allows the vagina to stretch during intercourse and childbirth
Muscularis
continuous with that of the uterus
Mucosa
Thin mucous membrane
Usually partially closes the inferior end of the vagina
Found in infant and toddler females
Hymen