Exam #6: Basal Ganglia Function Flashcards
Define akinesia.
Lack of movement
Define chroea.
Abnormal brief, random, twitch-like involuntary movement (dance-like)
Define bradykinesia.
Slowness in the execution of movement
Define atheotosis.
Slow, worm-like, writhing movements
Define hemiballismus/ ballismus.
Involunatary, violent, flinging movements of a limb while awake
- Ballismus= bilateral
Define dyskinesia.
General term for involuntary movements
Define freezing of gait.
Seen in PD, patients will:
1) Suddenly be unable to start walking
2) Stop moving forward while walking
Define festinating gait.
Abnormal gait seen in PD with small shuffling steps & absence of arm swing
What are the structures that compose the basal ganglia?
- Caudate
- Putamen
- Globus pallidus (internal & external segments)
- Subthalamic nucleus
- Substantia nigra (pars reticulata & pars compacta)
Outline the nigrotriatial pathway. What NT is important in this pathway?
SNc to Striatum
- DA
- Has both excitatory and inhibitory effects
Outline the corticostriate pathway. What NT is important in this pathway?
Cortex to striaum
- Excitatory
- Release glutamate
Outline the pathway from the GPe to GPi. What NT is important in this pathway?
Striatum to GPe= GABA/ enkephalin (path. in Huntington’s)
Striatum to GPi= GABA
Is GABA excitatory or inhibitory?
Inhibitory
Is Glutamate excitatory or inhibitory?
Excitatory
What are the symptoms of PD?
- Resting tremor
- Rigidity (“cogwheel”)
- Slowness of movement
- Postural instability