Exam #5: Gastric Motility Flashcards

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1
Q

What is the migrating motor complex?

A

GI motor activity that starts in the stomach and sweeps over the upper GI tract ~Q90min in the unfed state

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2
Q

What are the three general types of motor activity in the stomach?

A

1) Storage= reservoir
2) Churning= mixing & initiation of digestion
3) Emptying= delivery of food to the duodenum

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3
Q

What is receptive relaxation?

A

This is a vagovagal reflex that is initiated by swallowing; there is a reflexive relaxation of the stomach in anticipation of the food bolus

*****Allows for a rise in volume without a rise in pressure

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4
Q

What mediates receptive relaxation?

A

Vagovagal reflex that is described as “Non-cholingeric/ Non-adrenergic”

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5
Q

What does Non-cholingeric/ Non-adrenergic mean?

A

This is a kind of archaic term that typically refers to the action of NO, before it was known that NO played a role

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6
Q

What is gastric accommodation?

A

This is stomach relaxation in response to gastric filling i.e. now stomach contents stretching the walls of the stomach lead to the release of NO that causes a relaxation of the stomach

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7
Q

What are the two steps of gastric storing/ filling?

A

1) Receptive relaxation

2) Gastric accomodation

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8
Q

What are the three parts of gastric churning?

A

1) Propulsion
2) Retropulsion
3) Grinding

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9
Q

What is propulsion?

A

Movement of the contents toward the antrum/ pylorus

*****Note that the pylorus is closed

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10
Q

What initiates propulsion?

A

Pacemaker cells near the greater curvature

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11
Q

What happens after propulsion?

A

Propulsion of food against the closed pylorus results in pulverization and shearing of food

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12
Q

What is grinding?

A

This is the process by which food is trapped in the antrum & food products smaller than 2mm pass through the pylorus

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13
Q

What determines the rate of gastric emptying?

A

Content of the ingested material

  • Liquid is fastest
  • Glucose solution
  • Protein and fat breakdown slowest
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14
Q

What controls the rate of gastric emptying?

A

Neuronal & hormonal regulation

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15
Q

What are the hormones that control gastric emptying? Summarize the stimuli that cause their secretion.

A
Secretin= HCl- duodenum
CCK= Fat- duodenum 
Gastrin= Protein- stomach
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16
Q

What is the stimulus for Secretin secretion? What is the function of Secretin?

A
  • HCl in duodenum results in delayed gastric emptying

- This is a protective

17
Q

What is the stimulus for CCK secretion? What is the function of CCK?

A
  • Fat in the duodenum stimulates the release of CCK
  • CCK feedback delays gastric emptying

This allows for efficient breakdown of the meal & increases the surface area for digestion

18
Q

What is the stimulus for Gastrin secretion? What is the function of Gastrin?

A
  • Protein in the stomach induces the release of gastrin

- Gastrin delays gastric emptying to increase the efficiency of protein digestion in the stomach

19
Q

What is the role of duodenal distension?

A

Duodenal distention results in negative feedback on the stomach mediated by the ENS to delay gastric emptying

20
Q

What are the effect of ACh, opoids, and 5-HT on gastric emptying?

A

Delay

21
Q

What is the effect of NO & VIP on gastric emptying?

A

Promotion of gastric emptying

22
Q

What is gastroparesis?

A

Simply, gastroparesis= impaired motility

**Note that this is NOT a COMPLETE PARALYSIS; rather, a disruption of normal coordinated activity that leads to a delay in emptying that is more often NEURONAL in origin (vs. hormonal)

23
Q

Outline the emetic response.

A

1) Numerous peripheral stimuli converge on the emetric center in the medulla
2) Vomiting reflex
- reverse peristalsis in small intestine
- relax stomach
- forced inspiration
- sphincter relaxation
- expulsion

*****This reflex is under the control of: 5-HT, ACh, DA & Histamine

24
Q

Why is there increased salivary secretion prior to an emetic event?

A

This increased salivary production is protective, as it contains:

  • HCO3-
  • Mucin
25
Q

What are the molecular mechanisms that coordinate vomiting?

A

5-HT*, DA, ACh, & Histamine

26
Q

What are potentially good anti-emetic agents?

A

Drugs that block 5-HT, DA, ACh, and histamine