Exam 6 Flashcards
waste products
produced from all cells
enter blood from tissues
filtered from blood via kidneys
eliminated in urine
kidneys job
filter blood
ureters funktion
transport urine
bladder funktion
stores urine
urethra funktion
eliminated urine
other funktions of kidneys
regulate ion levels and acid base balance regulate blood pressure eliminate molecules calcirtriol produce and release erythropoietin
hilum of kidneys
where vessels, nerves, ureters connect to kidney
location of kidneys
partially protected by rib cage
posterior to parietal peritoneum
fibrous capsule
dense CT to surface of kidney
protects from trauma
prevents pathogen invasion
fat on kidneys
adipose CT on fibrous capsule
cushions and supports kidneys
renal fascia
dense CT
anchors kidney to surrounding surfaces
renal columns
extension of cortect projecting into medulla
renal pyramids
portion of medulla divided by renal columns
renal papilla connects them to renal sinus
renal lobe
renal cortex external to base
renal sinus
medially located urine drainage area
calcyes
minor calyces
structure of renal pyramids
renal pelvis
formed from merged calyces
arteries, veins, lymoh vessels, erves, fat
nephron
funktional filteration unit of kidney
renal corpuscle
glomerulus and glomerular capsule
glomerulus
tangled network of capillaries
blood enters via afferent
blood exits via efferent
glomerular capsule
internal permeable visceral layer
external impermeable epithelium
recieves filtrate in between
renal tubule
last part of nephron
pct, loop, dct
PCT
connected to glomerular capsule
microvilli increase surface area and reabsorption capacity
nephron loop
descending and ascending loop
DCT
extends to collecting tubule
no microvilli
two types of nephrons
cortical
juxtamedullary
cortical nephron
short nephron loop penetrating medulla
resides in cortex
juxtamedullary nephron
help establish salt concentration gradient
urine concentration
nephron drainage
drian into collecting tubules
enters collecting ducts
project toward renal papilla
principal cells
responsive to hormones aldosterone and ADH
intercalated cells
regulate urine pH and blood pH
juxtamedullary apparatus
regulate blood filtrate formation, systemic BP
granular cells
modified smooth muscle cells of afferent arteriole
sythensize, store, and release renin
macula densa
in walls of DCT
detect changes in NaCl concentration
blood flow through kidney
filtrate formed when blood flows through glomeruls
enter capsular space
flows through structures
arteries in kidney
blood enters via renal artery
afferent arteriole
enters renal corpuscle forming glomerulus
efferent arteriole
blood exiting glomerulus
branches into capillaries or vasa recta
peritubular capillaries
intertwined PCT and DCT
vasa recta
associated with loop of henle
medulla of kidney
allows blood to move from capillary beds
gas exchange in kidney
vasa recta
veins in kidneys
drain peritubular and vasa recta capillary beds
renal vein
filtrate
both water and solutes filtered from blood
tubular fluid
name for filtrate in PCT
called urine after entering collecting ducts
urine
enter papillary ducts
flows through renal sinus
minor-majory-renal pelvis
renal pelvis to ureter then bladder
glomerular filteration
separates water and dissolved solute from blood
due to pressure differences across filteration membrane
tubular reabsorption
movement of components within tubular fluid
move via diffusions, osmosis, or active transport
move from lumen of tubules and collecting ducts
return to blood via capillaries
water and vital solutes reabsorbed
tubular secretion
move of solutes out of blood
move into tubular fluid
material selevtively itno tubules to be excreted
filteration membrane
porous, thin, negatively charged
glomerulus and visceral layer
endothelium of glomerulus
close to lumen layer
slits allow plasma to be filtered
restricts passage of large structures
basement membrane of glomerulus
porous middle layer
restricts passage of large plasma proteins
visceral layer of glomerular capsuke
outermost layer made of podocyes
filteration slits
mesangial cells
cells in between glomerular capillary loops
phagocytic and contractile properties
net filteration pressure
hydrostatic pressure of blood in glomerulus
opposing: osmotic BP and capsular BP
glomerular hydrostatic (blood) pressure
BP in glomerulus pushes water and solute out of glomerulus pushed into capsular space high than BP of systemic capillaries smaller diamter of efferent arteriole
blood colloid osmotic pressure
osmotic pressure exerted by dissolved solutes
fluid back into glomerulus
pressure favoring filteration
out of blood
glomerular BP
capsular osmotic pressure
pressure opposing filteration
into the blood
blood osmotic pressure
capsular hydrostatic pressure
capsular hydrostatic pressure
pressure in glomerular capsule due to filtrate
impedes movement of fluid
net filteration pressure
pressures promoting filtration are greater than pressures opposing
glomerular filteration rate
rate at which volume of filterate is formed
tightly regulated
control urine production
influence changing diameter of afferent artreiole
increase NFP
increase GFR
increase solutes and water in fluid
increase substances in urine
decrease filtrate reabsorption
renal autoregulation (intrinsic)
maintain constant BP and GFR despite changes in systemic arterial pressure
myogenic and tubuloglomerular feedback
myogenic response
contraction of smooth muscle of afferent arteriole
decrease BP, less stretch
vessels dialte=more blood
GFR remains normal
increase BP, more stretch
vessles contract= less blood
GFR remains normal
tubuloglomerular feedback mechanism
backup to myogenic response due to incerase BP
glomerular BP increase, NaCl increase
detect via macula densa
vasoconstiction
limitations to maintaining GFR
renal autoregulation
decrease BP below 80
increase BP above 180
decrease BP below 80
arterioles max dilation
decrease glomerular BP and GFR
cessation of waste elmination in pee
increase BP above 180
arterioles max constriction
increase glomerular BP and GFR
increase urine
kidney extrinisic control
neural and hormonal
decrease with extensive sympathetic stimulation
increase with ANP stimulation
sympathetic stimulation of kidney
decrease GFR through vasoconstriction of afferent
increase output during exercise or emregency
constriction of arterioles
reduces blood flow to glomerulus
release renin
decrease urine
atrial natriuretic peptide (ANP)
release from cardiac muscle cells respond to increase stretch of heart chambers relaxes afferent arterioles inhibitd release of reniin rekax mesangial cells increase GFR and urine
what is 100% reabsorbed
glucose
reabsorption of nutrients
normally completely reabsorbed in PCT
reabsorption of proteins
most not freely filtered due to size and neg charge
glucosuria
excretion of glucose in urine
osmotic diuretic- pulls water into tubulae fluid
loss of fluid in urine
sodium reabsorption
almost all reabsorbed from tubular fluid along tubule
requires Na/K pumps
actively pumped out of tubule into ISF
creates concentration gradient
water reabsorption
varies along tubule
most in PCT
potassium reabsorption
reabsorbed and secreted may be net reabsorption or secretion
bicarbonate and H resorption
regulate pH
bicarb freely filered-almost all reabsorbed
descending limb
concentrates filtrate
permeable to water
impermeable to salts
ascending limb
dilutes filtrate
impermeable to water
Na, K, bicarb reabsorbed
aldosterone
increase Na reabsorption-water follows
stimulates increase secretion of K
elevated K= aldosterone release
ANP on reabsorption
inhibits reabsorption of Na in PCT
inhibits release of aldosterone
ADH on rebsorption
increase aquaporins
water leaves filtrate=enters blood
increase water independent of Na
if blood becomes acidic
synthesize bicarb=reasorbed into blood
H excreted within filtrate
increase blood pH and decrease urine pH
if blood becomes alkalotic
secrete bicarb and reasorb H
lower blood pH
increase urine pH
urinary system prevents accumulation of
metabolic waste various hormones and metabolites foreign substances some substances filtered at glomerulus other secreted along tubule
nitrogenous waste
metabolic watse containing nitrogen and waste products
urea
molecule produced from protein breakdown
establish concentration gradient in ISF
reabsorbed in secreted
uric acid
produced from nucleic acid breakdown in liver
reabsorbed and secreted
creatinine
produced from creatinin metabolism in muscle
only secreted
elimination of drugs and bioactive substances
most secretion in PCT
concentration gradient
established by various solutes
increase in concentration from cortex into medula
osmotic pull to move water into ISF
descending loop concentration
concentrates filtrate by removing water
water leave cuz higher concentration in ISF
water leaves to enter blood
dilutes blood
ascending loop concentration
dilutes filtrate by removing Na
impermeable to water
Na enter blood
concentrates blood
urine
product of filtered and processed blood plasma
urine volume
varies due to fluid intake, BP, meds
min .5 L to eliminate waste a day
urine pH
between 4.5-8
influenced by metabolism, infection
urine color
clear to dark yellow
increase volume=lighter color
urine smell
urinoid-normal smell
smelly if stagnant
ureters
muscular tubes
takes urine from kidneys to bladder
3 tunics
controlled by autonomic
mucosa of ureter
transitional ET
distensible and impermeable to urine
folds to fill lumen when empty
muscularies of ureters
inner long and outer circular of smooth muscle
contracts
propels urine into bladder
adventitia of ureters
external
collagen and elastic fibers
compressed as bladder distends
bladdder
muscular container to hold urine
4 tunics
mucose of bladder
transitional ET
accommodates change with shape
mucosal folds fro distension
submucosa of bladder
outside mucosa
muscularis of bladder
3 layers of smooth muscle
detrusor muscle
involuntary internal urethral sphincter
adventitia of bladder
outer
forms serosa
urethra
takes urine to outside of body
2 spincters
internal urethral sphincter
involuntary superior sphincter
smooth muscle
neck of bladder
autonomic
external urethral sphincter
skeletal muscle
voluntary sphincter controlled by somatic
micturition
peeing
2 reflexes
sympathetic (storage) and parasympathetic (pee)
sympathetic stimulation of bladder
contraction of internal sphincter
inhibits contraction of detrusor muscle and peeing
parasympathetic stimulation of bladder
contraction of detrusor and relaxation of internal sphincter
stimulates peeing
somatic nervous system
prevents urination
storage reflex
continous sympathetic stimulation
relax detrusor muscle
contract internal sphincter
micturition reflex
bladder distended and baroreceptors activated
detrusor muscle contract
internal sphincter relax
conscious control of urination
cerebral cortex via pudendal nerve
voluntary contraction of abdominal muscles
digestive system
break down nutruents
ingest, mix, propel food
6 funktions of digestive system
ingestion motility secretion digestion absorption elimination
ingestion
intro of solid and liquid nutrients in oral cavity
motility
voluntary and involuntary muscular contractions
mixng and moving material through tract
secretion
process of producing and releasing fluid
enzymes
digestion
breakdown of ingested food into small pieces
mechanical digestion
physical chewing and mixing
chemical digestion
enzymes to break chemical bonds
absorption
transport of digested molecules, electrolytes, vitamins, water
blood to lymph
elimination
expulsion of indigestible components not absorbed
accessory digestive organs
glands, liver, pancreas, teeht, tongue, gallbladder
mucosa of GI tract
mucous membrane
3 layers