Exam 5: THE BIG ONE.....AUTONOMICS Flashcards
What are the 5 types of receptors in the autonomic nervous system?
Nicotinic (Ach), Muscarinic (Ach), Adrenergic: Alpha, Beta-1, & Beta-2 (NorEpi)
What are the two ligands of the autonomic nervous system?
Acetylcholine and Epinephrine/NorEpinephrine
For the Sympathetic Nervous system: describe the length of the Pre-ganglionic fibers.
Short!
For the Parasympathetic nervous systems: describe the length of preganglionic fibers.
Long!
For the Sympathetic Nervous system: describe the length of the post-ganglionic fibers.
Long!
For the Parasympathetic nervous systems: describe the length of post-ganglionic fibers.
Short!
What are the two receptors involved in the parasympathetic nervous system?
nicotinic and muscarinic (both use Ach as the ligand)
What are the 4 receptors used in the sympathetic nervous system?
Nicotinic (Ach), Alpha (NE), Beta-1 (NE), Beta-2 (Ne)
For the nicotinic receptors…..Where are N1 or Nm receptors found?
NeuroMuscular Junction
For the nicotinic receptors…Where are N2 or Nn receptors found? (3)
Autonomic ganglia, CNS, and the adrenal medulla
What are the 4 groups of drugs that alter the ANS?
1.Parasympathetic Stimulatory 2. Parasympathetic Inhibitory (blocking) 3.Sympathetic Stimulatory 4.Sympathetic Inhibitory (blocking)
Can both divisions of the ANS (sym and parasym) be affected by a drug that only targets one division?
YES. Both divisions can be affected by these drugs
A drug that acts at the location where acetylcholine is released is termed = ________.
Chol-in-ergic
A drug that acts at the location where norepinephrine is released is termed = ________.
Adren-ergic
A drug that acts at the location where the PANS acts has the prefix ________.
parasympatho-
A drug that acts at the location where the SANS acts has the prefix ________.
sympatho-
A drug that acts at the location where a division of the ANS acts and produces the SAME EFFECT as the neurotransmitter has the suffix _______.
– mimetic (salagen-a parasympathomimetic)
A mimetic drug is also known as an _______.
agonist
A drug that acts at the location where a division of the ANS acts and blocks the action of the neurotransmitter has the suffix –_____ or –_____…they are also known as _______.
-lytic….-blocker…antagonists
What are the two types of STIMULATORY Parasympathetic Drugs?
1.Cholinergics 2. Parasympathomimetics
What are the 3 types of INHIBITORY Parasympathetic drugs?
1.Anticholinergics 2.Parasympatholytics 3.Cholinergic blockers
What are the 2 types of STIMULATORY Sympathetic drugs?
1.Adrenergics 2.Sympathomimetics
What are the 3 types of INHIBITORY Sympathetic drugs?
1.adrenergic blockers 2.sympathetic blockers 3.sympatholytics
What are the 2 methods of action for cholinergic agonists?
1.Direct acting-agonists (at the Ach receptor) 2.Indirect acting (causes Ach release) (chopinesterase inhibitors)
______________ = cause accumulation of ACH = stimulating PANS
Cholinesterase inhibitors
Which drugs act like acetylcholine (“mimic” its effects) on receptors, are agonists, have longer duration of action, are more selective in the effects produced, and stimulate the PANS?
Direct Acting Cholinergic Drugs
To be an effective mediator/ligand, ACH must fit both _______ and _______ at the receptor.
physically and chemically
What are the two types of PANS ACh receptors?
1.Nicotinic 2.Muscarinic
What are the 2 types of receptors in the PANS CNS?
1.muscarinic 2.nicotinic
What are the 2 types of receptors in the PANS Autonomic system?
1.Muscarinic 2.nicotininc
What is the type of receptor found in the PANS neuromuscular system?
nicotinic
What are the 3 other factors that account for different receptor responses besides just being different receptors?
1.Amount of ACh released 2.Size of the synaptic cleft 3.Tissue penetration of the drug
What are the 3 cardiac effects of cholinergic drugs?
1.(tom) Bradycardia 2.decreased BP 3. decreased cardiac output
What are the 2 eye effects of cholinergic drugs?
1.Miosis 2.Decreases intraocular pressure