Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHRM 845 Therapeutics > Exam 5 - Lec 69 Depression Ott > Flashcards

Exam 5 - Lec 69 Depression Ott Flashcards

1
Q

risk of recurrence of depression:

1 episode: ___-___%
2 episodes: ___%
3 episodes: ___%

A

50-60%
70%
90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T or F: risk of recurrence becomes higher over time as duration of remission increases

A

F (lower over time)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T or F: persistent mild sx during remission is a predictor of recurrence

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which is FALSE about recurrence?

a. risk becomes lower over time as duration of remission decreases
b. persistent mild sx during remission is a predictor of recurrence
c. function deteriorates during the episode and goes back to baseline upon remission

A

a. risk becomes lower over time as duration of remission decreases (not decreases; should be increases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

DSM-5 diagnostic criteria for depression: at least one of the symptoms must be depressed mood or ?

a. insomnia
b. loss of interest/pleasure in doing things
c. fatigue
d. weight or appetite change

A

b. loss of interest/pleasure in doing things

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DSM-5 diagnostic criteria mnemonic

A

SIGE CAPS

Sleep
Interest decreased
Guilt/worthlessness
Energy loss/fatigue
Concentration difficulties
Appetite change
Psychomotor agitation/retardation
Suicidal ideation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the two self-administered rating scales for depression

A

PHQ-9 and MDQ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which rating scale can be used to rule out bipolar disorder?

a. PHQ-9
b. MDQ

A

b. MDQ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which rating scale was developed for the primary care setting?

a. PHQ-9
b. MDQ

A

a. PHQ-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

look at slide 11 for the 4 goals of tx

A

ok

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

goal of the acute phase of depression tx

a. induce remission
b. prevent relapse
c. prevent recurrence

A

a. induce remission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

goal of the continuation phase of depression tx

a. induce remission
b. prevent relapse
c. prevent recurrence

A

b. prevent relapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

goal of the maintenance phase of depression tx

a. induce remission
b. prevent relapse
c. prevent recurrence

A

c. prevent recurrence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

boxed warning for all antidepressant meds

A

suicidality in pts 24 or younger

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

which of the following SSRIs can cause QTc prolongation?

a. citalopram
b. escitalopram
c. fluoxetine
d. sertraline

A

a. citalopram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which SSRI is a substrate of 2C19 and 3A4?

a. citalopram
b. fluoxetine
c. fluvoxamine
d. paroxetine

A

a. citalopram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

which SSRI has the longest half-life and has activating potential?

a. citalopram
b. fluoxetine
c. paroxetine
d. sertraline

A

b. fluoxetine (96-144 hours)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is the active metabolite of fluoxetine and which CYP does it inhibit?

A

norfluoxetine; 3A4 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

which SSRI is a 1A2, 2C19 inhibitor?

a. sertraline
b. fluvoxamine
c. fluoxetine
d. paroxetine

A

b. fluvoxamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

which SSRI must be tapered due to anticholinergic effects?

a. paroxetine
b. sertraline
c. citalopram
d. fluvoxamine

A

a. paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

which SSRI is a 2D6, 2B6 inhibitor?

a. citalopram
b. sertraline
c. paroxetine
d. fluoxetine

A

c. paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

which SSRI causes weight gain, sedation, and has a septal wall defect risk to the fetus?

a. sertraline
b. fluvoxamine
c. citalopram
d. paroxetine

A

d. paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

which drug causes more nausea/GI upset than other antidepressants?

a. citalopram
b. fluoxetine
c. paroxetine
d. sertraline

A

d. sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

fluoxetine is an inhibitor of which CYP?

A

2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
which SSRI causes weight loss? a. paroxetine b. fluoxetine c. escitalopram
b. fluoxetine
26
3 bolded AEs of SSRIs to know (slide 17)
-inc bleeding risk (platelet inhibition) -hyponatremia (especially in elderly) -sexual dysfunction
27
active metabolite of venlafaxine
desvenlafaxine
28
which SNRI has a dose-limiting SE of nausea? a. desvenlafaxine b. duloxetine c. levomilnacipran d. venlafaxine
a. desvenlafaxine (duloxetine also has nausea)
29
which SNRI has no major CYP interactions? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
a. desvenlafaxine
30
which SNRI has a FDA warning for hepatotoxicity? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
b. duloxetine
31
which SNRI is a 2D6 inhibitor? (2 of them; one is a 2D6 inhibitor at high dose) a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
b. duloxetine e. venlafaxine (at high doses)
32
which SNRI must be adjusted in renal impairment or with strong 3A4 inhibitor? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
c. levomilnacipran
33
which SNRI is a 3A4 substrate? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
c. levomilnacipran
34
which SNRI must be > 150 mg/day to have NE effects? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
e. venlafaxine
35
SNRIs AEs (2 of them in bold)
BP elevation, nausea
36
with which SNRI should we obtain LFTs at baseline and when symptomatic or every 6 months? a. desvenlafaxine b. duloxetine c. levomilnacipran d. milnacipran e. venlafaxine
b. duloxetine
37
useful in pain syndrome, musculoskeletal pain, fibromyalgia, and neuropathic pain a. SSRIs b. SNRIs c. TCAs
b. SNRIs
38
amitriptyline is a ______ amine a. secondary b. tertiary c. tetracyclic
b. tertiary
39
TCAs are more often used for _____ _____ syndromes than depression
neuropathic pain
40
look at slide 21 for TCAs AEs
you got it
41
TCAs have a narrow therapeutic index and are fatal in overdose as low as _______ mg (4-10 tablets) due to cardiac arrhythmias or seizures
1000 mg
42
which MAOI does NOT require a low tyramine diet? a. isocarboxazid b. phenelzine c. selegiline d. tranylcypromaine
c. selegiline
43
how long should the washout period be before switching antidepressants?
2 seeks (5 weeks for fluoxetine)
44
T or F: MAOIs should be used with caution due to hypertensive crisis and serotonin syndrome
T
45
MOA of bupropion (2 things bolded)
-DNRI -stimulating - insomnia and appetite suppression
46
bupropion is CI in active _____ and _____ disorders
seizure; eating
47
bupropion is a ____ inhibitor (CYP)
2D6
48
T or F: bupropion and mirtazapine should NOT be used in combo with SSRI/SNRIs
F (can be used in combo with SSRIs/SNRIs)
49
for mirtazapine, sedation and inc appetite occur with doses of ___ mg/day or less
15 mg/day
50
two warnings for mirtazapine
agranulocytosis; inc cholesterol
51
T or F: low doses of trazodone are used for depression
F (higher doses needed)
52
SE of trazodone (2 bolded)
-orthostatic hypotension -risk of priapism (medical emergency)
53
vilazodone mechanism
primarily SSRI, may have some 5HT1A agonism which may provide anxiolytic effects
54
T or F: vilazodone or vortioxetine should NOT be used in combo with SSRI/SNRIs
T
55
vilazodone is a ___ substrate
3A4
56
why should vilazodone be taken with food? (2 things bolded)
-significant nausea -bioavailability inc with food
57
which drug's mechanism is a SSRI + 5HT1A agonist + 5HT3 antagonist? a. vilazodone b. bupropion c. vortioxetine
c. vortioxetine
58
AE of vortioxetine (only one bolded)
nausea
59
vortioxetine is a ___ substrate
2D6
60
T or F: vortioxetine has more sexual dysfunction than other antidepressants
F (possibly less)
61
antidepressant withdrawal syndrome is common with ALL antidepressants EXCEPT a. duloxetine b. paroxetine c. fluoxetine d. sertraline
c. fluoxetine
62
T or F: antidepressant withdrawal syndrome is life threatening
F
63
antidepressants with __________ activity should be tapered no matter what
anticholinergic
64
4 atypical FDA-approved augmentation agents
-aripiprazole -brexpiprazole -cariprazine -quetiapine
65
which of the following is FALSE about electroconvulsive therapy? a. 2-3 times weekly as induction b. usual course is 6-12 treatments c. age is not a factor d. can continue drug therapy e. unsafe in pregnancy f. can have temporary memory loss g. CI in recent MI or hemorrhagic stroke
e. unsafe in pregnancy (it is safe)
66

PHRM 845 Therapeutics (34 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions