Exam 3 - Lec 44 Alzheimers Rochet Flashcards
which of the following are intracellular and consist of hyper-phosphorylated tau?
a. amyloid plaques
b. neurofibrillary tangles
b. neurofibrillary tangles
Synapse loss in Alzheimers results in reduced levels of which 4 neurotransmitters?
mainly ACh, but also serotonin, norephinephrine, and dopamine
mutations in which genes are linked to early onset AD? (2 of them)
-genes encoding APP (amyloid beta precursor protein)
-genes encoding presenilin proteins involved in cleaving amyloid beta from APP
the APP gene is located on which chromosome?
21 (Trisomy 21/Down’s syndrome is assoc with an AD-like phenotype in 4th decade of life)
individuals with how many ApoE4 alleles have an inc risk of AD?
one or two
individuals who inherit the _____ allele decreases AD risk
a. ApoE1
b. ApoE2
c. ApoE3
d. ApoE4
b. ApoE2
3 cholinesterase inhibitor drugs for AD
-donepezil
-rivastigmine
-galantamine
which is a radiolabeled agent that binds B-amyloid, visualized by PET scanning?
a. Florbetapir
b. Galantamine
c. Donepezil
d. Aducanumab
e. Memantine
a. Florbetapir
memantine MOA
NMDA antag that blocks glutamergic neurotransmission via a noncompetitive mech, reduces excitotoxicity
what drug is memantine ER + donepezil?
Namzaric
what is the radiolabeled agent specific for tau?
18F-Flortaucipir
which non-AD dementia is described?
-impaired judgement or executive function
-brain injury assoc with vascular disease or stroke
a. vascular dementia
b. dementia with Lewy bodies
c. frontotemporal dementia
a. vascular dementia
which non-AD dementia is described?
-combo of cognitive decline and PD symptoms
-visual hallucinations are a core diagnostic feature
a. vascular dementia
b. dementia with Lewy bodies
c. frontotemporal dementia
b. dementia with Lewy bodies
which non-AD dementia is described?
-disinhibited behavior
-tau accumulations
a. vascular dementia
b. dementia with Lewy bodies
c. frontotemporal dementia
c. frontotemporal dementia
