Exam 5 - Alcohol Use Watts Flashcards

1
Q

alcohol peak absorption range (in minutes)

A

30-90 min

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2
Q

alcohol elim follows ____ order kinetics at or above 10-20 mg/dL

A

zero

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3
Q

when is alcohol metabolized by the MEOS? Which CYP is involved?

A

only at high conc; CYP2E1

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4
Q

fomepizole is an _____ inhibitor

A

ADH (alcohol dehydrogenase)

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5
Q

alcohol is mainly metabolized by what enzyme?

A

alcohol dehydrogenase

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6
Q

what is fomepizole used for and how does it work?

A

used for ethylene glycol, methanol poisoning; slows formation of formaldehyde and toxic metabolites

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7
Q

acetaldehyde is metabolized by what enzyme?

A

acetaldehyde dehydrogenase

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8
Q

which SNP in ALDH2 reduces activity?

a. ALDH2 *1
b. ALDH2 *2
c. ALDH2 *6
d. ALDH2 *17

A

b. ALDH2 *2

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9
Q

disulfiram is a _______ inhibitor of ALDH

a. reversible
b. irreversible

A

b. irreversible

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10
Q

alcohol is an allosteric activator of inhibitory NTs at which receptors?

A

GABA-A

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11
Q

T or F: alcohol causes release of enkephalins

A

T

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12
Q

CNS stimulation occurs at what BAC range?

a. 30-60 mg/dL
b. 60-90 mg/dL
c. 80-120 mg/dL
d. 100-200 mg/dL

A

c. 80-120 mg/dL

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13
Q

euphoria, disinhibition, being more talkative occurs at what BAC range?

a. 30-60 mg/dL
b. 60-90 mg/dL
c. 80-120 mg/dL
d. 100-200 mg/dL

A

a. 30-60 mg/dL

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14
Q

alcohol has an analgesic effect at what BAC range?

a. 30-60 mg/dL
b. 60-90 mg/dL
c. 80-120 mg/dL
d. 100-200 mg/dL

A

b. 60-90 mg/dL

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15
Q

CNS depression occurs at what BAC range?

a. 30-60 mg/dL
b. 60-90 mg/dL
c. 80-120 mg/dL
d. 100-200 mg/dL

A

d. 100-200 mg/dL

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16
Q

which of the following is FALSE about the CV effects of alcohol?

a. vasodilation occurs with acute use
b. inc risk of coronary disease with moderate use
c. cardiomyopathy can occur with chronic use
d. binge drinking can cause arrhythmias

A

b. inc risk of coronary disease with moderate use (dec risk due to inc HDL)

17
Q

T or F: alcohol consumption causes hyperthermia

A

F (hypothermia; ppl who drink alcohol may have the illusion of warmth however)

18
Q

alcohol is a _______ in the GI system

A

secretagogue (inc secretions)

19
Q

which of the following is FALSE about the long-term effects of alcohol on the liver?

a. inc fat metabolism
b. fatty liver leads to cirrhosis
c. vitamin deficiencies
d. glutathione increased
e. can cause ascites, edema, effusions

A

d. glutathione increased (reduced)

20
Q

drug used to detoxify NAPQI

A

n-acetylcysteine (NAC)

21
Q

alcohol and acetaminophen use casues an increase in which toxic metabolite?

22
Q

which of the following is NOT an aldehyde dehydrogenase inhibitor?

a. opioids
b. disulfiram
c. metronidazole
d. cephalosporins
e. tolbutamide

A

a. opioids

23
Q

1 in ___ US adults meet alcohol use disorder criteria

24
Q

3 FDA approved drugs for alcoholism

A

disulfiram
acamprosate
naltrexone

25
aldehyde dehydrogenase inhibitor a. disulfiram b. acamprosate c. naltrexone
a. disulfiram
26
NMDA antagonist/GABA agonist a. disulfiram b. acamprosate c. naltrexone
b. acamprosate
27
opioid receptor antagonist a. disulfiram b. acamprosate c. naltrexone
c. naltrexone
28
causes flushing, throbbing, headache, N&V, sweating, hypotension, confusion a. disulfiram b. acamprosate c. naltrexone
a. disulfiram
29
pts should be alcohol free for 24 hours a. disulfiram b. acamprosate c. naltrexone
a. disulfiram
30
_______ is more effective in pts with an SNP in the mu opioid receptor gene a. disulfiram b. acamprosate c. naltrexone
c. naltrexone (look for 118G mutation)
31
the alanine118glycine mutation changes what amino acids? What does this do?
changes asparagine to aspartate which has 3x higher potency for beta-endorphins, pts will respond better to naltrexone
32
3 off-label drugs for alcoholism
topiramate baclofen varenicline
33
inhibits glutamate signaling, enhances GABA signaling a. topiramate b. baclofen c. varenicline
a. topiramate
34
has similar mechanism to acamprosate a. topiramate b. baclofen c. varenicline
a. topiramate
35
stimulates GABA-B receptors a. topiramate b. baclofen c. varenicline
b. baclofen
36
nicotinic acetylcholine receptor partial agonist a. topiramate b. baclofen c. varenicline
c. varenicline