Exam 4 - Short Answer / Fill in the blank

Question 1

Limitations to Cancer Drug Design

Answer 1

1. Can’t target ‘loose’ genetic material
2. Activting a mechanism that has been turned off is difficult
3. Oncogenes/oncoproteins are better targets than tumor suppressors
4. Enzymes are good targets
5. Protein-protein interactions – good targets
6. Kinases are the most popular targets

Question 2

Process of Cancer Drug Design

Answer 2

1. Does the compound work?
2. Cell assay
3. Animal studies
4. Phase I: Clinical Trials

Question 3

Cell Assay

Answer 3

1. Does the drug adversely affect cells?
   – Gleeve and IL-3 required for growth
2. Add plasmid (Bcr-Abl to produce IL-3)
3. Remove IL-3, if cells die with Gleevec then it is safe