Exam 4 - Definitions

Question 1

MMPs

Answer 1

• Function to degrade components of the extracellular matrix.
• These enzymes are often manufactured by inflammatory cells
• Deregulation can drive progression of cells through all the stages of mult-step tumorigenesis

Question 2

Triad

Answer 2

Cancer, Endothelial, Macrophages

Question 3

Invasion-Metastasis Cascade

Answer 3

1. Primary tumor formation: cells must breach the basement membrane and move into the stroma
2. Intravasation: Cells cross the endothelial layer an enter the blood vessels; interacts with blood components
3. Transportation through Circulation: Arrest in microvessels of various organs
4. Extravasation: Formation of micrometastasis
5. Colonization: Ability of stray cancer cells to grow and form a macrometastasis
   rate determining step

Question 4

Cancer = Metastasis

Answer 4

The only way cancer becomes inherently dangerous, otherwise it can be removed

Question 5

Altered Metabolism

Answer 5

Radioactive glucose can make cancer visible

Question 6

Twist Protein

Answer 6

Promotes transition from epithelial to mesenchymal cells by activating a single gene