Exam 4 Module 7 Flashcards
Adrenergic receptors
Alpha 1 and 2
Beta 1 and 2
Alpha 1 receptor effects
Smooth muscle contraction
Vasoconstriction - increase BP
Pupil dilation
Decreased urination
Alpha 2 receptor
Inhibitory at presynapse
Vasodlation lower BP
Beta 1 effects
increased HR, contraction force, cardiac output
Renin release fluid retention
Beta 2 effects
Smooth muscle relaxation
Lungs, blood vessels, bladder
Vasodilation lowers BP
bronchodilation
decreased urination (relaxation of detrusor muscles)
Adverse effect of beta-blockers
Bradycardia, Fatigue, dizziness, nausea/vomitting
Medications can be administered to increase blood pressue
Alpha 1 and beta 1 agonists
Epinephrine (A1 and B1)
Noreepinephrine (B1)
Phenylephrine (A1)
Dopamine (B1)
Parasympathetic receptors
Nicotinic
Muscarinic
Nicotinic receptors
Fast response
CNS Excitatation
Muscarinic Receptors
SLOW metabolism
Excitatory/inhibitory
DUMBELLS symptoms
D iarrhea
U rination
M iosis
B radycardia
E mesis
L acrimation
L ethargy
S alivation
DUCT symptoms
D ry mouth
U rinary retention
C onstipation
T achycardia
Adverse effects of beta blockers
Bradycardia, Fatigue, dizziness, N/V
Meds to increase blood pressure
Alpha 1 and beta 1 agonists
Epinephrine (A1 and B1)
Norepinephrine (A1)
Isoproterenol (B1)
Phenylephrine (A1)
Dopamine (B1)
S/S of cholinergic overdose/crisis
DUMBELLS
What are pharmacological treatment options for cholinergic overdose crisis?
Atropine (anticholinergic, antimuscarininc)
Adverse effects associated with anticholinergic medications?
D ry eyes
D ry mouth
U rinary retention
C onstipation
C onfusion
T achycardia
Causes of malignant hyperthermia?
Succinylcholine
Compare depolarizing and non-depolarizing neuromuscular blockers
Succinylcholine : short procedures
Pancoronium (rocuronium): Long procedures
What are the pharmacological treatment options for myasthenia gravis
Pyridostigmine (Inhibits Acetylcholinesterase)
Edrophonium: Diagnosing between Myasthenia gravis and Cholinergic Crisis
Albuterol I, MOA, AE, CI
MOA: Beta 2 agonist
I: Asthma, copd bronchospasms
CI: hypertension, hear issues
AE; hypokalemia, tachycardia
Clonidine I, MOA, AE, CI
MOA: less Norepinephrine, A2 agonist
I: alcohol withdrawal, hypertension
CI: anticoagulant
AE rebound hypertension
Epinephrine: I, MOA, AE, CI
MOA: A1 and 2, B1 and 2 agonist
I: Anaphylaxis, status asthmaticus
AE: Dysrhythmia, hypertension
CI: Close-angle glaucoma, CAD, hypertension
Metoprolol I, MOA, AE, CI
MOA: Beta 1 antagonist
I: Hypertension
CI: bradycardia, AV block, Hypotension
AE: ^^ + N/V, dizziness, fatigue
Norepinephrine I, MOA, AE, CI
MOA: Alpha 1 agonist
I: Severe hypotension
CI: closed angle glaucoma, CAD, hypertension
AE: dysrhythmia, hypertension, anxiety
Propanolol I, MOA, AE, CI
MOA: Beta1 and 2 antagonist
I: Hypertension, post Mi
CI: COPD/ Asthma
AE: Bradycardia, fatigue, gi upset
Phenylephrine I, MOA, AE, CI
MOA: A1 agonist
I: Nasal decongestions
CI: closed angle glaucoms, hypertension, angina
AE: sneezing (nasal spray), rebound congestion
Prazosin I, MOA, AE, CI
MOA: A1 antagonist
I: hypertension, BPH, Raynaud’s
CI: CAD, Renal impairment
AE: tachycardia, 1st dose,
Terbutaline I, MOA, AE, CI
MOA: B2 agonist
I: asthma
CI:liver disease
AE: tachycardia,
Atropine I, MOA, AE, CI
MOA: Muscarinic receptor antagonist
I: Organophosphate poisoning
CI Acute angle glaucoma, heart failure, COPD
AE: DDUCCT, (drying)
(Scopolamine)
Bethanechol I, MOA, AE, CI
MOA: Muscarinic agonist
I: Urinary retention
CI: Urinary obstruction, peptic ulcer disease, asthma, heart failure
AE: increased gastric acid secretion DUMBELLS
(Pilocarpine, carbachol)
Edrophonium I, MOA, AE, CI
MOA: inhibits acetylcholinesterase
I: Differentiation of myasthenia gravis and choinergic crisis
CI: Urinary obstruction, asthma
AE: Chest pain, trouble breathing
Oxybutynin I, MOA, AE, CI
MOA: muscarinic receptors antagonist
I: overactive blladder
CI: closed angle glaucoma, myasthenia gravis, urinary retention
AE: DDUCCT
Succinylcholine I, MOA, AE, CI
MOA: Depolarizes nicotinic receptors
I: Short procedures
CI: history of malignant hyperthermia
AE: Paralysis of diaphragm, respiratory depression
