Exam 3 - Schizophrenia and other psychotic disorders Flashcards

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1
Q

What is the hallmark of schizophrenia?

A

psychosis - a significant loss of contact with reality

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2
Q

When was the first clinical description of schizophrenia?

A

1810

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3
Q

What are the risk factors for schizophrenia?

A
  • Lifetime prevalence​
  • Age of father​
  • Country​
  • Onset age​
  • Gender
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4
Q

What is the age of onset for schizophrenia? Gender differences?

A
  • 18-30
  • Males peak @ 20-24
  • Women peak @ 40 and just after 60
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5
Q

What are the hallmark symptoms of schizophrenia?

A
  • delusions
  • hallucinations
  • disorganized speech
  • disorganized and catatonic behavior
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6
Q

Delusions

A
  • erroneous belief
  • fixed and firmly held
  • disturbance in the content of thought
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7
Q

Hallucinations

A
  • sensory experience, can occur in any sensory modality, but the most common is auditory
  • seems real but occurs in absence of any external perceptual stimulus
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8
Q

What are neologisms?

A

form of disorganized speech, made up words that sound like real words

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9
Q

Disorganized speech

A
  • manifestation of delusions
  • failure to make sense - have a multitude of thoughts in the middle of sentences
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10
Q

Disorganized and catatonic behavior

A
  • impairment of goal-directed activity
  • occurs in areas of daily functioning
  • almost no movement
  • disregard personal safety and hygiene
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11
Q

What are the positive symptoms of schizophrenia?

A
  • delusions and hallucinations
  • normal people do not exhibit these symptoms
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12
Q

What are the negative symptoms of schizophrenia?

A
  • decreased speech and catatonia
  • absence or deficit of normally present behaviors
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13
Q

Schizoaffective disorder

A

have all of the symptoms of schizophrenia, and a mood disorder

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14
Q

Schizophreniform disorder

A

schizophrenia symptoms for no longer than 6 months, usually about 1 month

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15
Q

Delusional disorder

A

normal overall, but have delusions

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16
Q

Brief psychotic disorder

A

experience all of the symptoms of schizophrenia for only a few days due to stress

17
Q

Shared psychotic disorder

A

sharing a delusion with someone

18
Q

Genetic factors are clearly implicated in schizophrenia. True or false?

A

True, the closer the relation, the more at risk

19
Q

What are the prenatal exposure causal factors for schizophrenia?

A
  • prenatal infections
  • rhesus incompatibility (R+ mom and R- infant)
  • early nutritional deficiencies
  • perinatal birth complications (hypoxia, breaching, etc.)
20
Q

Brain lesions/abnormalities lie ______ until normal developmental changes occur.

A

dormant

21
Q

What brain areas are abnormal in schizophrenia?

A
  • decreased brain volume
  • enlarged ventricles
  • frontal lobe dysfunction (underactive frontal lobe)
  • reduced volume of the thalamus
  • abnormalities in temporal lobe areas (auditory stimuli are processed here)
22
Q

Brain abnormalities are found in all patients with schizophrenia. True or false?

A

False

23
Q

Which neurotransmitters are implicated in schizophrenia, and what symptoms are they responsible for?

A
  • dopamine - positive symptoms
  • glutamate - positive and negative symptoms
24
Q

The ____________ of the brain may also be implicated in schizophrenia.

A

cytoarchitecture

25
Q

Do “bad families” cause schizophrenia?

A

No, they are not the sole cause, but they can cause a relapse or be a trigger for it.

26
Q

What are the psychosocial and cultural aspects of schizophrenia?

A
  • socioeconomic status
  • immigrants
  • cannabis smokers
27
Q

What are the pharmacological treatments for schizophrenia? Which of these helps with positive and negative symptoms?

A
  • antipsychotics and second-generation antipsychotics
  • second-generation antipsychotics
28
Q

What are the psychosocial approaches to treating schizophrenia?

A
  • family therapy
  • case management
  • social-skills training
  • cognitive remediation
  • CBT (not as effective for negative symptoms)
  • stress management to avoid relapse
29
Q

Who is Wednesday the Rat?

A

Jenny’s hallucination/delusion

30
Q

What is the long-term institutionalization rate for individuals with schizophrenia?

A

about 12%

31
Q

How many patients with schizophrenia had improved?

A

about 38% in 15-25 year outcomes

32
Q

What are neologisms?

A

form of disorganized speech, made up words that sound like real words