exam 3: salivary glands Flashcards
saliva is involved to some degree in all of the following functions
x10
speech
mastication
taste
swallowing
digestion
protection
buffering
antimicrobial action
maintenance of tooth integrity
soft tissue repair
protein thought to be necessary for growth and maturation and taste buds
gustin
this degrades starch in digestion
salivary amylase
prevents potential pathogenic bacteria from colonizing the mouth (most require an acidic pH)
microbrial acids
buffering
protein that raises pH of dental plaque after exposure to fermentable carbohydrates
sialin
hydrolyzes bacterial cell walls
lysozyme (antimicrobial action)
binds free iron and thereby deprives bacteria of an essential nutrient
lactoferrin (antimicrobial action)
causes bacterial clumping (agglutination)
salivary IgA (antimicrobial action)
calcium and phosphate ions faciliate mineralization of tooth surface
maintenance of tooth integrity
epithelial growth factor
clotting factor
soft tissue repair
________cells dictate differentiation of oral epithelium which in turn proliferates and grows into the underlying mesenchyme.
the epithelial buds undergo histodifferentiation and morphodifferentiation to form assemblies of
ectomesenchymal cells
alveoli that devleop into acinar cells
and
epithelial cords that develop into ducts
stages of salivary gland development:
1
2
3
4
5
6
- induction of oral epithelium by underlying ectomesenchyme
- growth of epithelial cord
- initiation of epithelial cord branching
- repetitive branching and lobule formation
- canalization of the presumptive ducts
- cytodifferentiation to become acinar cells, myoepithelial cells, and ductal cells
last stage of salivary gland development is cytodifferentiation to become acinar cells, myoepithelial cells, and ductal cells with what two growth factors
FGF (fibroblast gf)
EGF (epidermal gf)
salivary glands-development and structure
FGF + EGF + terminal bulb cells ->
acinar cells
myoepithelial cells
duct cells
the parotid and submandibular glands begin to form during the _______ of embryonic development with the sublingual gland initiating development during the ______
6th week
8th week
the minor salivary glands begin to form by the ______ of embryonic development
10th week
hierarchy of ducts starting at the level of the secreting unit (acinus)
intercellular canaliculus
intercalated duct
striated duct
excretory duct (aka collecting duct)
associated with terminal end pieces (acini) and intercalated ducts
myoepithelial cells (aka basket cells)
stenson’s duct
parotid gland
wharton’s duct
submandibular gland