Exam 3 Part I Flashcards
increased Temperature = _______ MAC = ____________ potency = ___________ Oil : gas solubility coefficient
increase; decrease; decrease
methods of pain relief prior to 1840
- drugs: hashish, alcohol, opium derivatives 2. physical methods: packing limb in ice, ischemia with a tourniquet, blow to the head, strangulation 3. restraints
Inhalation agents are highly _________ soluble and _____________
lipid; diffusible
level of anesthesia is related to the ________________________ of the anesthetic agents which is continuously measured via _________________
alveolar concentration; End tidal (of the agent)
____________/_____________ of inhalational agent in in the lungs is ASSUMED (only assumption) to be the same as in the _____________
concentration/partial pressure; brain
T/F: inhalational agents quickly reach equilibirium in the highly perfused body compartments (central compartment/vessel rich group)
TRUE
end tidal of inhalational agent takes about ______________ minutes before it is truly representative of brain concentration
15 min
how do you control the inspired partial pressure of inhlational agent
adjusting the dial
factors that affect the inhalational agent uptake d/t solubility in the anesthesia machine
- solubility of agent in the ventilator 2. solubility of agent in absorbent 3. small quantities of agent are retained in the machine
solubility effects of inhalational agents in the anesthesia machine potentially ______________ administration, but effects cease after ____________ minutes of administration
slows; 15
small quantities of inhalational agent being retained in the machine is a huge issue for ___________________
malignant hyperthermia susceptible patients
all anesthetic gases are triggers of MH except ________________
N2O
how can you decrease the risk of MH in suceptible patients 2/2 anesthesia machine retaining small quantities of inhalational agents
flush machine prior to use: 1. 100% O2 at 10L/min 2. run for 20 minutes 3. change absorbant 4. remove vaporizers 5. may vary by machine ideal: INH free machine (i.e. machine that has never had gas run through it)
____________ fresh gas flow increases the speed of uptake of INH agent
increasing
what is THE most important way to increase the partial pressure of volatile agent in the lungs
fresh gas flow
when you want to quickly increase the speed of uptake (P.P of agent) of INH agent you should increase the FGF to _____________
6-8 L/min
the saturation of agent in the lungs is based on _____________________
first order kinetics (fraction of drug picked up/unit of time)
what is time constraints
calculates the time to get to 95% (of INH) max concentration of the circuit
how many time constraints = 95% max [ ] of the circuit
3
what is the calculation for time constraint based on flow?
TC = volume of circuit (constant #)/FGF = time (min) –> time (min) x 3 time constraints = 95% max [ ] of the circuit
Vapor pressure is _______________ dependent
temperature
Inhalational agents are ______________ at room temperature
liquids
what is room temperature
20 C (68 F)
temperature vapor pressure relationship is based off ________________ prinicple
LeChateliers