Brandon's supplemental Test 1 Cards Flashcards
Which medication is an ideal neuroprotectant and anti-convulsant, but can also cause be proconvulsant?
Thiopental
Which drug is a proconvulsant and ideal for ECT?
methohexital
which meds can cause centrally mediated muscle relaxation?
benzos
benzos at low dose?
anxiolysis
benzos at high dose
sedation
Can benzos cause isoelectric EEG?
NO!
Which meds decrease CMRO2 ICP and CBF?
Barbs
Benzos
which meds decrease CMRO2 ICP and CPP?
propofol & Etomidate
At high doses what medication can cause isoelectric EEG?
propofol
which medications causes cerebral vasoconstriction?
propofol and etomidate
When combined with other agents, which medication can be neuroprotectant?
propofol
Which medication has no effect on CMRO2 or ICP but does decrease CBF?
dexmedetomidine
Cardiac effects of benzos?
cardiac stable unless after induction dose, then it can decrease SVR and BP
CV effects of propofol?
decrease BP, MAP, CO,
decrease SNS tone
decrase baro receptor mediated response
CV effects of Barbituates?
pronounced decrease in MAP and CO, negative inotrope. Venodilation
Reflex increase in HR
CV effects of etomidate
cardiac stable unless dose >0.3mg/kg, then severe drop in BP and CO
CV effects of dexmedetomidine
decrease BP and HR,
can cause HTN with fast IV push of large dose
CV effects of ketamine
increase everything unless endogenous catecholamines are depleted, than decrease in BP and CO can be observed
when do you see apnea with barbs?
after 1-5 min
Which medications depress the respiratory center?
Barbs
Benzos (mostly midazolam)
etomidate
can brevital cause hiccups?
yes
which med causes histamine release and why is that bad?
thiopental. Can cause bronchospasm/laryngospasm
When do do see ventilatory response to CO2 with barbs?
in 6min
What meds depress upper airway relfexes?
benzos. Especially with opioids
so be careful in osa and compromised airways.
does propofol cause bronchodilation?
No straight from nagelhout
when does propofol cause apnea?
high dose
which drug decreases MV but ^ RR?
etomidate
which meds maintain upper airway reflexes?
etomidate
ketamine
When does etomidate or ketamine cause apnea?
high dose, especially with opioids
only induction agent that is a bronchodilator?
ketamine
why is there increased risk of laryngospasm with ketamine?
increased salivation, so give with glycopyrolate but be careful of HR.
Which induction agent can cause decreased airway reactivity in COPD patients?
precedex
which induction agent decreases salivation?
precedex
Which inducation agent is good for focal but not global injuries due to reverse steal effect
barbituates
