Exam 3 - Lymphatic and Respiratory Flashcards

1
Q

What is an immune system?

A

It is not an organ system but a cell population that inhabits all organs and defends the body from agents of disease

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2
Q

What is the lymphatic system?

A

It is a network of organs and vein-like vessels that recover fluid, activate immune responses, inspect for disease agents, and return fluid to bloodstream

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3
Q

What is the lymphatic fluid recovery system?

A

Fluid continually filters from the blood capillaries into the tissue spaces

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4
Q

How much of the fluid goes into the lymphatic system?

A

15% (2 to 4 L/day) of the water and half the plasma proteins go into it and then are returned to the blood

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5
Q

What is lymph and what does it look like?

A

The recovered fluid. It is a clear, colorless fluid that originates as extracellular fluid

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6
Q

What are lymphatic vessels?

A

They are vessels that transport the lymph

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7
Q

What are lymphatic tissues?

A

They are composed of aggregates of lymphocytes and macrophages that populate many organs in the body

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8
Q

What are lymphatic organs?

A

Organs where defense cells are concentrated and are separated from surrounding organs by connective tissue capsules

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9
Q

What are lymphatic capillaries (also known as terminal lymphatics)?

A

They penetrate nearly every tissue of the body where it is closed on one end and covered by endothelial cells.

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10
Q

What doe lymphatic vessels do?

A

Converge into larger and larger vessels and have collecting vessels that go through many lymph nodes

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11
Q

What do the 6 lymphatic trunks do?

A

Drain major portions of body

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12
Q

What are the two collecting ducts?

A

Right lymphatic duct and thoracic duct

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13
Q

What does the right lymphatic duct do?

A

Receives lymph from right arm, right side of head and thorax; empties into right subclavian vein

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14
Q

What does the thoracic duct do?

A

It is larger and longer; and begins in a sac in the abdomen where it receives lymph from below the diaphragm and left side of the body where it empties into the left subclavian vein.

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15
Q

Where does most of the lymph go to?

A

The thoracic duct; it does the lower body and the left side of the upper body

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16
Q

When does lymph flow?

A

At low pressure and slower speed then venous blood

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17
Q

How is lymph moved through vessels?

A

Rhythmic contractions

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18
Q

What is the flow of lymph?

A

1- aided by skeletal muscle pump
2- arterial pulsation rhythmically squeezes lymphatic vessels
3- thoracic pump aids flow from abdominal to thoracic cavity
4- Valves prevent backward flow
5- the rapid flowing blood in subclavian veins draws lymph into it

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19
Q

What increases lymphatic return?

A

exercise

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20
Q

What are natural killer (NK) cells?

A

Large lymphocytes

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21
Q

What do NK cells do?

A

Attack and destroy bacteria, transplanted tissues, host cells that are infected, or turned cancerous

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22
Q

Where are T lymphocytes (T cells) matured?

A

In the thymus

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23
Q

What do B lymphocytes (B cells) do?

A

When activated causes proliferation and differentiation into plasma cells that then produce antibodies

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24
Q

What are Macrophages?

A

Antigen-presenting cells (APCs)

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25
Q

What do macrophages do?

A

Process foreign matter and display antigenic fragments to certain T cells that alert immune system

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26
Q

What are dendritic cells?

A

Branched mobile APCs

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27
Q

What do dendritic cells do?

A

Alert immune system to pathogens that have breached the body surface and migrate to lymph nodes to activate immune reaction

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28
Q

What are reticular cells?

A

Branched stationary cells

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29
Q

What are lymphatic nodules (follicles)?

A

Dense masses of lymphocytes and macrophages that congregate in response to pathogens

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30
Q

What does red bone marrow and thymus do to help the lymphatic system?

A

They are the site where T and B cells become immunocompetent

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31
Q

What does immunocompetent mean?

A

When the cells are able to recognize and respond to antigens

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32
Q

What are the primary lymphatic organs?

A

Red bone marrow and thymus

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33
Q

What are the secondary lymphatic organs?

A

Lymph nodes, tonsils, and spleen

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34
Q

What happens in the secondary lymphatic organs?

A

Immunocompetent cells populate these tissues

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35
Q

What is the thymus?

A

A bilobed organ that has fibrous capsule that divide the gland into several lobe; includes reticular epithelial cells tat seal off cortex from medulla

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36
Q

What are lymph nodes purpose?

A

Cleanse the lymph and act as a site of T and B cell activationW

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37
Q

What are the two vessels in lymph nodes?

A

Afferent lymphatic vessel and efferent lymphatic vessels

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38
Q

What does afferent lymphatic vessel do?

A

They lead into the node along its convex surface

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39
Q

What does efferent lymphatic vessel do?

A

The lymph will leave the node through them that leave the hilum

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40
Q

Does the lymph node fill up or drain faster?

A

It has 4 faucets but only 1 drain so it will go in quicker than it will leave

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41
Q

How many afferent lymphatic vessels and efferent lymphatic vessels do a single lymph node have?

A

1 efferent and 4 afferent

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42
Q

What are tonsils?

A

Patches of lymphatic tissue at the entrance to the pharynx

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43
Q

What do tonsils do?

A

Guard against ingested or inhaled pathogens

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44
Q

What are the 3 main sets of tonsils?

A

Palatine tonsils, lingual tonsils, and pharyngeal tonsils

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45
Q

Where are palatine tonsils?

A

At posterior margin of oral cavity

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46
Q

Where are lingual tonsils?

A

Pair at root of tongue

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47
Q

Where are pharyngeal tonsils (adenoids)?

A

Single tonsil on wall of nasopharynx

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48
Q

What is the spleen?

A

The body’s largest lymphatic organ

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49
Q

What does the spleen do?

A

Having RBC come and go, will kill the old and fragile RBC. The white pulp monitors blood from foreign antigen

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50
Q

What are the first line of defense?

A

Skin and mucous membranes

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51
Q

What are the second line of defense?

A

Several nonspecific defense mechanism

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52
Q

What are the third line of defense?

A

The immune system

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53
Q

What is nonspecific immunity?

A

What all humans are born with, so skin, mucous membranes, etc.

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54
Q

What are specific immunity?

A

Immunity that your body has learned so B and T cells

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55
Q

What does nonspecific defenses do?

A

They guard equally against a broad range of pathogens

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56
Q

What is specific or adaptive immunity?

A

When the body must develop separate immunity to each pathogen

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57
Q

What do neutrophils do?

A

Wandering connective tissue killing bacteria

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58
Q

How does neutrophils kill bacteria?

A

Produces a cloud of bactericidal chemicals and kills all around it and itself

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59
Q

What do eosinophils do?

A

Guard against parasites, allergens, and other pathogens

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60
Q

Where are eosinophils found?

A

Mainly in mucous membranes

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61
Q

How do eosinophils kill?

A

Promote action of basophils and mast cells; limit action of histamine and other inflammatory chemical

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62
Q

What do basophils do?

A

Secrete chemical that aid other leukocytes

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63
Q

What chemicals do basophils secrete?

A

Leukotrienes, histamine, and heparin

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64
Q

What does leukotrienes do?

A

Activate and attract neutrophils and eosinophils

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65
Q

What does histamine do?

A

A vasodilator, increases blood flow

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66
Q

What does heparin do?

A

Inhibits clot formation

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67
Q

What are the categories of lymphocytes?

A

T,B, and NK cells

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68
Q

What do monocytes do?

A

Transform into macrophages

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69
Q

What do wandering macrophages do?

A

Actively seek pathogens

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70
Q

What do fixed macrophages do?

A

It will phagocytize only pathogens that come to them

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71
Q

What are interferons?

A

They are secreted by certain cells that are infected by viruses

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72
Q

What does interferons do?

A

Activate NK cells and macrophages

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73
Q

What do NK cells do?

A

Bind to enemy cell, release perforins that create a hole in its plasma membrane, secrete granzymes that induce apoptosis

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74
Q

Why does our body create fevers?

A

To promote interferon activity and accelerates tissue repair

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75
Q

What do neutrophils do when you puncture yourself?

A

Release selectins to cause leukocytes to adhere to the blood vessel wall and release chemotaxis that attract chemicals to the injury site

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76
Q

What do monocytes do to tissue cleanup?

A

Main agents; engulf and destroy bacterial, damaged host cells, and dead/dying neutrophils

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77
Q

What are the two characteristics that distinguish immunity from nonspecific resistance?

A

Specificity - immunity directed against a particular pathogen
Memory - when reexposed to the same pathogen, the body reacts so quickly

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78
Q

What is cellular immunity?

A

When lymphocytes directly attack and destroy foreign cells, rids the body of pathogens, and kills cells that harbor them

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79
Q

What is humoral immunity?

A

Mediated by antibodies that do no directly destroy but tag the pathogen for destruction. Only works against extracellular stages of infections

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80
Q

What is natural active immunity?

A

When the production of one’s own antibodies or T cells as a result of infection

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81
Q

What is artificial active immunity?

A

Production of ones own antibodies or T cells as a result of vaccination against disease

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82
Q

What is natural passive immunity?

A

Temporary immunity that results from antibodies produced by another person

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83
Q

What is artificial passive immunity?

A

Temporary immunity that results from the injection of immune serum from another person or animal

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84
Q

What are antigen?

A

Any molecule that triggers an immune response

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85
Q

What are epitopes?

A

Certain regions of an antigen molecule that stimulate immune responses

86
Q

What is MH class 1 do?

A

It sits on the membrane of a cell, it will hold any antigen and alert the body if it’s a foreign one.

87
Q

What are Cytotoxic T cells?

A

Killer T cells that are effectors of cellular immunity; carry out the attacks

88
Q

What are Helper T cells?

A

They promote the Tc cells and B cell action and nonspecific resistance

89
Q

What are Regulatory T cells?

A

Inhibit multiplication and cytokine secretion by other T cells: limit immune response

90
Q

What are memory T cells?

A

Descend from the cytotoxic T cells, responsible for memory in cellular immunity

91
Q

What is the native lymphocyte pool?

A

Immunocompetent T cells that have not yet encountered foreign antigens

92
Q

Where are B cells developed?

A

In the bone marrow

93
Q

What does both B cells and T cells go through if they fail their test?

A

Anergy or clonal deletion

94
Q

What do T cells need to find antigens?

A

Antigen-presenting cells because they cannot recognize antigens on their own

95
Q

What determine the function of APCs?

A

The major histocompatibility (MHC) complex proteins

96
Q

What does the MH class 2 show?

A

It will show if it is destroying the bacteria

97
Q

What do Tc cells respond only to?

A

MHC-1 proteins

98
Q

What do Th cells respond only to?

A

MHC-2 proteins

99
Q

What happens when T cell is activated?

A

Costimulation will trigger clonal selection when the T cell goes through mitosis giving rise to identical T cells programmed against the same epitope; some become effector cells other become memory T cells.

100
Q

What happens when a helper T cell recognizes the Ag-MHCP complex?

A

Secretes interleukins that attract Neutrophils, NK cells, macrophages, and stimulate T and B cell mitosis

101
Q

What is immunoglobulin (Ig)?

A

an antibody that is a defensive gamma globulin

102
Q

What are the actions of the immunoglobulin classes?

A

Neutralizing antigens, immobilizing bacteria, agglutinating and precipitating antigen, activating complement, and enhancing phagocytosis

103
Q

When are the IgG and IgM released?

A

During the humoral immunity response

104
Q

Which one is between IgG or IgM is better during the secondary response?

A

IgG

105
Q

What is the function of respiration?

A

Gas exchange, communication, olfaction, and acid-base balance, blood pressure regulation, blood and lymph flow, blood filtration, and expulsion of abdominal contents

106
Q

What does the air go through?

A

Nose, pharynx, larynx, trachea, bronchi, lungs, then stop in the alveoli

107
Q

What is the conducting division of the respiratory system?

A

No gas exchange, just passages that serve only for airflow, nostrils through major bronchioles.

108
Q

What is the respiratory division?

A

Consist of alveoli and other gas exchange regions

109
Q

What is the upper respiratory tract?

A

Nose, pharynx, then larynx

110
Q

What is the lower respiratory tract?

A

Trachea, bronchi, then lungs

111
Q

What are the functions of the nose?

A

Warms, cleans, and humidifies inhaled air; detects odors, amplifies voice

112
Q

What are the three regions of the pharynx?

A

Nasopharynx, oropharynx, and laryngopharynx

113
Q

What is the function of the larynx?

A

To keep food and drink out of the airway

114
Q

What is the epiglottis?

A

Flap of tissue that guards the superior opening of the larynx

115
Q

What are the first three large cartilage of the larynx?

A

Epiglottic, thyroid, and cricoid

116
Q

Where is the thyroid cartilage?

A

Adam’s apple

117
Q

What does the cricoid cartilage do?

A

Connects larynx to trachea

118
Q

What are the 3 smaller cartilage of the larynx?

A

Arytenoid, corniculate, and cuneiform

119
Q

Where is the arytenoid cartilage?

A

Posterior to thyroid cartilage (2)

120
Q

Where is the corniculate cartilage?

A

Attached to arytenoid, looks like horns (2)

121
Q

Where is the cuneiform cartilage?

A

Support tissue between arytenoids and epiglottis (2)

122
Q

What is the function of the trachea?

A

allows room for the esophagus to expand and contracts or relaxes to adjust airflow

123
Q

What is tracheostomy?

A

To make a temporary opening in the trachea and insert a tube to allow airflow

124
Q

What are the parts of the lungs?

A

The base, apex, costal surface, and mediastinal surface

125
Q

What is different about the right lung?

A

It is shorter then left because the liver is higher on the right - has three lobes, separated by horizontal and oblique fissure

126
Q

What is different about the left lung?

A

Tall and narrow because the heart, has a cardiac impression - 2 lobed and separated by a oblique fissure

127
Q

What are the regions of the bronchi?

A

It splits by the carina into the two main (primary) bronchi. Then the lobar (secondary) bronchi will branch off which then gets branched off into the segmental (tertiary) bronchi

128
Q

How many lobar do the left and right sides have?

A

The right have 3 and left has 2 (like lobes)

129
Q

How many segmental bronchi are on each side?

A

10 on right and 8 on left

130
Q

What are bronchioles?

A

The final branches of conducting division which then divided into a lot of terminal bronchioles.

131
Q

What are respiratory bronchioles?

A

The beginning of the respiratory division which then divide into alveolar ducts

132
Q

What are the squamous (type 1) alveolar cells?

A

Thin broad cells that allow for rapid gas diffusion. Cover 95%

133
Q

What are the great (type 2) alveolar cells?

A

Round to cuboidal cells that cover 5%, repair when the type 1 is damaged. also secrete pulmonary surfactant

134
Q

What are the alveolar macrophages cells?

A

Most numerous and keep alveoli free from debris by phagocytizing dust particles

135
Q

What is the respiratory membrane?

A

Thin barrier between the alveolar air and blood

136
Q

What does the respiratory membrane consist of?

A

Squamous alveolar cells, endothelial cells, and shared basement membrane

137
Q

How does oxygen move across the alveoli?

A

Through facilitated diffusion

138
Q

What is the visceral pleura?

A

Serous membrane that covers lungs

139
Q

What is parietal pleura?

A

Inner surface of rib cage and superior surface of the diaphragm

140
Q

What are the functions of pleura and pleural fluid?

A

Reduce friction, create pressure gradient (lower pressure than atmospheric pressure), and compartmentalization (prevents spread of infection)

141
Q

From superficial to deep, the order of the layers of the lungs?

A

Ribs - parietal pleura, pleural cavity (fluid), then visceral pleura - lung

142
Q

What is the diaphragm?

A

The prime mover of respiration, 2/3 of airflow

143
Q

What does contraction do the the diaphragm?

A

Flattens it by enlarging thoracic cavity and pulling air into lungs

144
Q

What does relaxation do to the diaphragm?

A

Allows it do bulge upward, compressing the lungs and expelling air

145
Q

What do the internal external intercostal muscles do during respiratory?

A

They stiffen the thoracic cage and prevent it from caving inwards when diaphragm descends; 1/3 airflow.

146
Q

What is normal quiet expiration?

A

An energy-saving passive process achieved by the elasticity of the lungs and thoracic cage

147
Q

What is forced expiration?

A

Greatly increased abdominal pressure pushes viscera up against diaphragm increasing thoracic pressure

148
Q

What is Valsalva maneuver?

A

Taking a deep breath, holding it by closing the glottis, then contracting the abdominal muscles to raise abdominal pressure and push organ contents out - vomiting, childbirth

149
Q

What is respiratory airflow proportional to?

A

The pressure difference between two points

150
Q

What drives respiration?

A

Atmospheric pressure

151
Q

What is Boyle’s law?

A

At a constant temp, the pressure of a given quantity of gas is inversely proportional to its volume

152
Q

What is intrapleural pressure?

A

The slightly negative pressure that exists between the two pleural layers (the -5)

153
Q

What is Charles’s law?

A

That volume of a gas is directly proportional to its absolute temperature

154
Q

What happens during quiet breathing?

A

The dimensions of the thoracic cage increases only a few millimeters in each direction

155
Q

What is relaxed breathing?

A

The passive process achieved mainly by elastic recoil of the thoracic cage, recoil compresses the lungs and volume of thoracic cavity decreases

156
Q

What is forced breathing?

A

Accessory muscles raise the intrapulmonary pressure as high as +40

157
Q

What is Pneumothorax?

A

Presence of air in pleural cavity, loss of negative intrapleural pressure allows lungs to recoil and collapse

158
Q

What is broncodilation?

A

When there is an increase in diameter of bronchus or bronchiole - increased airflow

159
Q

What causes the dilation of the bronchioles?

A

Epinephrine and sympathetic stimulation

160
Q

What is bronchoconstriction?

A

Decrease in diameter of bronchus or bronchiole - decreased airflow

161
Q

What caused bronchoconstriction?

A

Histamine, parasympathetic nerves, suffocation

162
Q

What is pulmonary compliance?

A

Ease with which the lungs can expand

163
Q

What limits pulmonary compliance?

A

Surface tension of the water film inside alveoli

164
Q

What is anatomic dead space?

A

Conducting division of airway where there is no gas exchange, altered somewhat by sympathetic and parasympathetic stimulation

165
Q

What is the tidal respiratory volume?

A

Volume of air inhaled and exhaled in one cycle

166
Q

What is inspiratory reserve volume?

A

Air in excess of tidal volume that can be inhaled with maximum effort

167
Q

What is expiratory reserve volume?

A

Air in excess of tidal volume that can be exhaled with maximum effort

168
Q

What is residual volume?

A

Air remaining in lungs after maximum expiration

169
Q

What is vital capacity?

A

Total amount of air that can be inhaled and then exhaled with maximum effort

170
Q

What is the formula to solve vital capacity?

A

VC= ERV +TV+IRV

171
Q

What is inspiratory capacity?

A

The maximum amount of air that can be inhaled after a normal tidal expiration

172
Q

What is the formula of inspiratory capacity?

A

IC = TV + IRV

173
Q

What is functional residual capacity?

A

Amount of air remaining in lungs after a normal tidal expiration

174
Q

What is the formula of functional residual capacity?

A

FRC = RV + ERV

175
Q

What is the formula lung capacity?

A

TLC = RV + VC

176
Q

What is the total lung capacity?

A

Maximum amount of air the lungs can contain

177
Q

What is Dalton’s law?

A

Total atmospheric pressure is the sum of the contributions of the individual gases

178
Q

What is Henry’s law?

A

At the air-water interface, for a given temperature, the amount of gas that dissolves in the water is determined by its solubility in water and its partial pressure in air

179
Q

What does “loaded” mean?

A

Something going into the blood

180
Q

What is the pressure gradient of CO2?

A

PCO2 = 46 mmHg in blood arriving vs 40 mm Hg in alveolar air

180
Q

What is the pressure gradient of oxygen?

A

PO2 = 104 mm Hg is alveolar air vs 40 mmHg in blood

181
Q

What is the relationship with surface area and diffusion?

A

They are proportional

182
Q

What does membrane thickness do?

A

Presents little obstacle to diffuse

183
Q

What does a thicker membrane do?

A

Gases have farther to travel between blood and air

184
Q

How does oxygen transport?

A

98.5% bound to hemoglobin and the rest dissolved in plasma

185
Q

How does carbon dioxide transport?

A

90% is hydrated to form carbonic acid, 5% is bound to proteins and 5% is dissolved as a gas in plasma

186
Q

How does carbon dioxide exchange?

A

70% of CO2 comes from carbonic acid, 23% comes from proteins, and 7% comes straight from plasma

187
Q

What is oxyhemoglobin?

A

When O2 bound to hemoglobin

188
Q

How many globins does each Hb molecule consist of?

A

4

189
Q

What does globin bind to?

A

CO2

190
Q

What is the formula of CO2 coming into the blood?

A

Carbon dioxide comes in and binds with water to from carbonic acid, then it is dissociated into bicarbonate and hydrogen ions.

191
Q

What two bind to the heme site on the hemoglobin?

A

Oxygen and carbon monoxide

192
Q

What causes the CO2 and H2O to form carbonic acid?

A

Carbonic anhydrase

193
Q

What pushes the carbonate into the plasma?

A

The Cl- shift

194
Q

Where does the H+ go after being dissociated from carbonic acid?

A

It will bind to the oxyhemoglobin causing a release of oxygen and deoxyhemoglobin going back into the blood

195
Q

How does the alveolar gas exchange mainly work?

A

Oxygen in the alveolar air will get a high concentration and take the H off the HHb causing it to then bind back with the carbonate and do the same formula as the systemic.

196
Q

What does CO2 do to pH levels?

A

It produces H making the pH lower

197
Q

What is acidosis?

A

When the blood pH is lower then 7.35

198
Q

What is alkalosis?

A

When the blood pH is higher then 7.45

199
Q

What is hypocapnia?

A

When the pressure of CO2 is less them 37 mmHg, it is caused by alkalosis

200
Q

What is hypercapnia?

A

When the pressure of CO2 is greater then 43 mmHg, caused by acidosis

201
Q

Why do we hyperventilate?

A

It is a corrective homeostatic response to acidosis

202
Q

Why do we hypoventilate?

A

It is a corrective homeostatic response to alkalosis

203
Q

How does CO2 affect respiration?

A

It has indirect effects, through pH

204
Q

What is Chronic Obstructive Pulmonary Disease (COPD)

A

Long-term obstruction of airflow and substantial reduction in pulmonary ventilation

205
Q

What is chronic bronchitis?

A

Severe, persistent inflammation of lower respiratory tract

206
Q

What happens during chronic bronchitis?

A

Production of excess mucus that causes bacterial growth and can cause a chronic cough

207
Q

What is Emphysema?

A

When the alveolar walls break down which causes less respiratory membrane for gas exchange

208
Q

What happens to the lungs during emphysema?

A

They become flabby and cavitated with large spaces

209
Q

What happens do the air passages in emphysema?

A

They collapse, air gets trapped in lungs and the person becomes barrel-chested, then weakens thoracic muscles

210
Q

What does COPD cause?

A

Hypoxemia, Hypercapnia, and respiratory acidosis

211
Q

What is Cor pulmonale?

A

Hypertrophy and potential failure of the right heart due to obstruction of pulmonary circulation