Exam 3 - Lymphatic and Respiratory Flashcards
What is an immune system?
It is not an organ system but a cell population that inhabits all organs and defends the body from agents of disease
What is the lymphatic system?
It is a network of organs and vein-like vessels that recover fluid, activate immune responses, inspect for disease agents, and return fluid to bloodstream
What is the lymphatic fluid recovery system?
Fluid continually filters from the blood capillaries into the tissue spaces
How much of the fluid goes into the lymphatic system?
15% (2 to 4 L/day) of the water and half the plasma proteins go into it and then are returned to the blood
What is lymph and what does it look like?
The recovered fluid. It is a clear, colorless fluid that originates as extracellular fluid
What are lymphatic vessels?
They are vessels that transport the lymph
What are lymphatic tissues?
They are composed of aggregates of lymphocytes and macrophages that populate many organs in the body
What are lymphatic organs?
Organs where defense cells are concentrated and are separated from surrounding organs by connective tissue capsules
What are lymphatic capillaries (also known as terminal lymphatics)?
They penetrate nearly every tissue of the body where it is closed on one end and covered by endothelial cells.
What doe lymphatic vessels do?
Converge into larger and larger vessels and have collecting vessels that go through many lymph nodes
What do the 6 lymphatic trunks do?
Drain major portions of body
What are the two collecting ducts?
Right lymphatic duct and thoracic duct
What does the right lymphatic duct do?
Receives lymph from right arm, right side of head and thorax; empties into right subclavian vein
What does the thoracic duct do?
It is larger and longer; and begins in a sac in the abdomen where it receives lymph from below the diaphragm and left side of the body where it empties into the left subclavian vein.
Where does most of the lymph go to?
The thoracic duct; it does the lower body and the left side of the upper body
When does lymph flow?
At low pressure and slower speed then venous blood
How is lymph moved through vessels?
Rhythmic contractions
What is the flow of lymph?
1- aided by skeletal muscle pump
2- arterial pulsation rhythmically squeezes lymphatic vessels
3- thoracic pump aids flow from abdominal to thoracic cavity
4- Valves prevent backward flow
5- the rapid flowing blood in subclavian veins draws lymph into it
What increases lymphatic return?
exercise
What are natural killer (NK) cells?
Large lymphocytes
What do NK cells do?
Attack and destroy bacteria, transplanted tissues, host cells that are infected, or turned cancerous
Where are T lymphocytes (T cells) matured?
In the thymus
What do B lymphocytes (B cells) do?
When activated causes proliferation and differentiation into plasma cells that then produce antibodies
What are Macrophages?
Antigen-presenting cells (APCs)
What do macrophages do?
Process foreign matter and display antigenic fragments to certain T cells that alert immune system
What are dendritic cells?
Branched mobile APCs
What do dendritic cells do?
Alert immune system to pathogens that have breached the body surface and migrate to lymph nodes to activate immune reaction
What are reticular cells?
Branched stationary cells
What are lymphatic nodules (follicles)?
Dense masses of lymphocytes and macrophages that congregate in response to pathogens
What does red bone marrow and thymus do to help the lymphatic system?
They are the site where T and B cells become immunocompetent
What does immunocompetent mean?
When the cells are able to recognize and respond to antigens
What are the primary lymphatic organs?
Red bone marrow and thymus
What are the secondary lymphatic organs?
Lymph nodes, tonsils, and spleen
What happens in the secondary lymphatic organs?
Immunocompetent cells populate these tissues
What is the thymus?
A bilobed organ that has fibrous capsule that divide the gland into several lobe; includes reticular epithelial cells tat seal off cortex from medulla
What are lymph nodes purpose?
Cleanse the lymph and act as a site of T and B cell activationW
What are the two vessels in lymph nodes?
Afferent lymphatic vessel and efferent lymphatic vessels
What does afferent lymphatic vessel do?
They lead into the node along its convex surface
What does efferent lymphatic vessel do?
The lymph will leave the node through them that leave the hilum
Does the lymph node fill up or drain faster?
It has 4 faucets but only 1 drain so it will go in quicker than it will leave
How many afferent lymphatic vessels and efferent lymphatic vessels do a single lymph node have?
1 efferent and 4 afferent
What are tonsils?
Patches of lymphatic tissue at the entrance to the pharynx
What do tonsils do?
Guard against ingested or inhaled pathogens
What are the 3 main sets of tonsils?
Palatine tonsils, lingual tonsils, and pharyngeal tonsils
Where are palatine tonsils?
At posterior margin of oral cavity
Where are lingual tonsils?
Pair at root of tongue
Where are pharyngeal tonsils (adenoids)?
Single tonsil on wall of nasopharynx
What is the spleen?
The body’s largest lymphatic organ
What does the spleen do?
Having RBC come and go, will kill the old and fragile RBC. The white pulp monitors blood from foreign antigen
What are the first line of defense?
Skin and mucous membranes
What are the second line of defense?
Several nonspecific defense mechanism
What are the third line of defense?
The immune system
What is nonspecific immunity?
What all humans are born with, so skin, mucous membranes, etc.
What are specific immunity?
Immunity that your body has learned so B and T cells
What does nonspecific defenses do?
They guard equally against a broad range of pathogens
What is specific or adaptive immunity?
When the body must develop separate immunity to each pathogen
What do neutrophils do?
Wandering connective tissue killing bacteria
How does neutrophils kill bacteria?
Produces a cloud of bactericidal chemicals and kills all around it and itself
What do eosinophils do?
Guard against parasites, allergens, and other pathogens
Where are eosinophils found?
Mainly in mucous membranes
How do eosinophils kill?
Promote action of basophils and mast cells; limit action of histamine and other inflammatory chemical
What do basophils do?
Secrete chemical that aid other leukocytes
What chemicals do basophils secrete?
Leukotrienes, histamine, and heparin
What does leukotrienes do?
Activate and attract neutrophils and eosinophils
What does histamine do?
A vasodilator, increases blood flow
What does heparin do?
Inhibits clot formation
What are the categories of lymphocytes?
T,B, and NK cells
What do monocytes do?
Transform into macrophages
What do wandering macrophages do?
Actively seek pathogens
What do fixed macrophages do?
It will phagocytize only pathogens that come to them
What are interferons?
They are secreted by certain cells that are infected by viruses
What does interferons do?
Activate NK cells and macrophages
What do NK cells do?
Bind to enemy cell, release perforins that create a hole in its plasma membrane, secrete granzymes that induce apoptosis
Why does our body create fevers?
To promote interferon activity and accelerates tissue repair
What do neutrophils do when you puncture yourself?
Release selectins to cause leukocytes to adhere to the blood vessel wall and release chemotaxis that attract chemicals to the injury site
What do monocytes do to tissue cleanup?
Main agents; engulf and destroy bacterial, damaged host cells, and dead/dying neutrophils
What are the two characteristics that distinguish immunity from nonspecific resistance?
Specificity - immunity directed against a particular pathogen
Memory - when reexposed to the same pathogen, the body reacts so quickly
What is cellular immunity?
When lymphocytes directly attack and destroy foreign cells, rids the body of pathogens, and kills cells that harbor them
What is humoral immunity?
Mediated by antibodies that do no directly destroy but tag the pathogen for destruction. Only works against extracellular stages of infections
What is natural active immunity?
When the production of one’s own antibodies or T cells as a result of infection
What is artificial active immunity?
Production of ones own antibodies or T cells as a result of vaccination against disease
What is natural passive immunity?
Temporary immunity that results from antibodies produced by another person
What is artificial passive immunity?
Temporary immunity that results from the injection of immune serum from another person or animal
What are antigen?
Any molecule that triggers an immune response