Exam 3 Flashcards
Causes of hyperlipidemia
Excessive dietary intake of fats.
Genetic alteration sin fat metabolism leading to a variety of elevated fats in the blood.
Action of Lipid lowering agents
Lower serum levels of cholesterol and lipids.
Prevention of CAD.
Drugs used to treat hyperlipemia.
Bile Acid Sequestrants HMG-CoA Inhibitors Fibrates Niacin Cholesterol Absorption Inhibitors Omega-3 Fatty Acids
Binds bile acids in the intestine, allows excretion in feces instead of reabsorption, causes cholesterol to be iodized in the liver, and serum cholesterol levels to fall
Action of Bile Acid Sequestrants
Reduces elevated serum cholesterol in patients with primary hypercholesterolemia, pruritus associated with partial biliary obstruction.
Indications for Bile Acid Sequestrants
Contraindications of Bile Acid Sequestrants
Allergy, Complete biliary obstruction, Abnormal intestinal function, Pregnancy and Lactation
Adverse Effects of Sequestrants
Headache, fatigue, and drowsiness, direct GI irritation- nausea, constipation, increased bleeding times vitamin A and E deficiencies
Nurse Assess Bile ACID
vital signs, lab values, pregnancy, physical assessment, allergy, teach mix with fluids do not use with other drugs.
Prototype for Bile Acid Seustrants
Cholestyramine
HMG-CoA Reductase inhibitors
-statin
Early are limiting step cellular cholesterol synthesis involves the enzyme HMG-CoA reductase. If this enzyme is blocked serum cholesterol and lDL Decrease.
Inhibits HMG-CoA, decreases serum cholesterol levels, LDLs and triglycerides, increases HDL levels.
Action of Reductase Inhibitors