Exam 3 Flashcards
what are the different ions that are involved in membrane potential?
K+
Na+
Cl-
Ca2+
what are the two different aspects of membrane potential?
concentration gradient
membrane permeability
what is a concentration gradient?
ions inside versus outside
what is membrane permeability?
K+ is the most permeable
what is influx?
ions into the cell
what is efflux?
ions out of the cell
what are the different ion channels?
mechanical
chemical
voltage-gated
what is a mechanical ion channel?
respond to pressure/stretch
what is a chemical ion channel?
respond to ligands
ex: neurotransmitter
what is a voltage-gated channel?
respond to changes in membrane potential
what is repolarization?
return to the resting membrane potential
neuron = -70mV
-usually the 2nd half of action potential
-K+ enters cell
-K+ channel is slow to open
-Na+ channels close
why are membrane potentials always fluctuating?
due to the influx of Na+ and Cl- and the efflux of K+
only a few ions are needed to cause a change
what is resting potential?
-70mV
what is polarization?
flow of electrical charge carried by an ion is called the ion current
what does the flow create?
polarization
what does polarization create?
an electrical signal
what are the two types of signals?
graded potential
action potential
what are some characteristics of graded potential?
variable-strength signal
travel short distance
what is action potential?
very brief
large depolarization
travel far
what do you need to create action potential?
graded potential
what is graded potential?
change in membrane potential whose size is proportional to the stimulus
where does graded potential occur?
dentrites
cell body
what might graded potential do?
trigger or inhibit action potential
what is hyperpolarization?
becoming more negative than resting potential
- last part of action potential
- final K+ channel closes
what is depolarization?
decreasing the membrane potential difference
generally = more positive mV
-usually at the start of an action potential
-Na+ channels are open
what are the four steps of graded potential?
- ion channels open
- membrane potential changes
- resistance/current causes current flow to decrease over distance
- may reach trigger zone if strong enough and cause action potential
what two things does the strength of potential depend on?
- strength of initial stimulus
2. distance from stimulating point
where is the trigger zone?
at the axon hillocks
there are a lot of __________ at the trigger zone
Na+ channels
what needs to happen for action potential to occur?
graded potential reaches zone and is above the threshold voltage
what is another name for trigger point?
threshold potential
where does threshold potential happen?
near -55 mV
what are the two different types of graded potential additive effects?
spatial summation
temporal summation
what is spatial summation?
graded potentials produce at the same time from different neuron
what is temporal summation?
graded potentials produced in the same neuron and close together in time
what happens when action potential begins?
it proceeds through the entire length to the axon
all-or-none
what is excitability?
ability of a neuron to respond rapidly to a stimulus and fire an action potential
what are the four phases of action potential?
resting
rising
falling
hyperpolarization
what is conduction?
movement of action potential through axon at high speed
how does axon diameter influence conduction speed?
larger is faster than smaller
how does myelination influence conduction speed?
presence of myelin allows salutatory conduction which increase action potential transfer speed
what is a synapse?
anatomical connection between neurons and their targets
-information transmission
what are the three regions of a synapse?
- axon terminal on presynaptic cell
- synaptic cleft
- membrane on post synaptic cell
what are the different kinds of cells that a synapse can be?
neurons
non-neuronal cell
what are the two different types of synapse?
electrical
chemical
what is a electrical synapse?
electrical signal passes directly from cytoplasm of one cell to another
what does an electrical synapse use to pass the electrical signal?
gap junction
where does electrical synapse occur?
in neurons of CNS
-also cardiac and smooth muscle
what is a chemical synapse?
electrical signal of presynaptic cell converted to chemical signal and sent across synapse
what does an chemical synapse use to pass the electrical signal?
neurohormones
neurotransmitters
what are the majority of synapses?
chemical
where does action potential arrive?
axon terminal
what happens after action potential reaches the axon terminal?
voltage gated Ca2+ channel opens
what does Ca2+ trigger?
exocytosis of vesicles
what happens after exocytosis of vesicles is triggered?
NT enter the synaptic cleft
what do the NT do after they enter the synaptic cleft?
bind to receptor on post synaptic cell
what happens after NT bind to receptor on post synaptic cell?
there is a cell response
what are the different types of chemicals used for NT?
amines purines gases peptides lipids AA
what are the different types of chemical signals?
paracrine
autocrine
in the CNS how many different kinds of NT are there?
many different kinds
in the PNS what are the different kinds of NT are there?
ACh
norepinephrine
epinephrine
what are the amino acid NT that excite?
glutamate
aspartate
what are the amino acid NT that inhibit?
glycine
GABA
what are the amine NT?
serotonin histamine dopamine norepinephrine epinephrine
what are the peptide NT?
substance P vasopressin somatostatin leu-enkephalin# met-enkephalin# beta-endorphin#
what are the purines NT?
adenosine
ATP
AMP
what are the gases NT?
NO
CO
what are the different methods that can be used to clear NT from that synapse?
removal from ECF
inactivation by enzymes
diffusion
what are some example of removing NT from the ECF of a synapse?
- bring back to the presynaptic cell
- norepinephrine - adjacent neurons/glial cells
- astrocytes
what are some example of inactivating NT by enzymes in a synapse?
ACh
AChE
what are two different ways to integrate neural info transfer?
divergence
convergence
what is divergence?
one presynaptic neuron + many postsynaptic neurons
what is convergence?
many presynaptic neurons + one postsynaptic neuron
what are the division of the nervous system?
central
peripheral
what are the two components of the CNS?
brain
spinal cord
what are the types of the neurons in the PNS?
afferent
efferent
what does an afferent neuron do?
detect stimuli
-sensory
what does an efferent neuron do?
trigger responses
-motor
what is the CNS surrounded by?
meninges
what are meninges?
layers of protective membranes that are specific to the CNS
what is the structure of PNS?
composed of spinal and cranial nerves that carry action potentials toward (afferent) or away from (efferent) the CNS
what is a nerve?
bundles of axons with CT
what is a ganglion?
mass of PNS cell bodies
what is a preganglionic?
occurring before a ganglion
what is a postganglionic?
occurring after a ganglion
what does a ganglion form into?
knots
swelling
what does a ganglion create?
satellite cells form supportive capsule around the cell bodies
what is a plexus?
groups of ganglia
what are the two different types of ganglia?
dorsal root
autonomic
what is the general layout of the PNS and the spinal cord?
afferent enters through dorsal root ganglion
efferent exits through ventral root
what is a root?
end of nerve
what is a dorsal root ganglia?
swellings on root
-cell bodies of sensory neurons
what is a ventral root?
carries info from CNS to muscle/glands
what is gray matter?
unmyelinated nerve cell bodies, dendrites, axon terminals
what does gray matter contain?
contains dorsal, lateral, and ventral horns