Exam 3 Flashcards
Intracellular Fluid
maintaining cell size
70% of total body fluid
about 40% of adult body weight is from ICF
Extracellular
30% of total body fluid and ~20% of body
weight
Intravascular fluid
Type of ECF
plasma of the blood
blood volume, impacts HR/BP
Interstitial Fluid
Type of ECF
surrounds cells
Trans Cellular
Cerebrospinal, Pleural,
Peritoneal, Synovial, Digestive secretions,
Sweat
OSMOLARITY
Concentration of particles in a solution
Isotonic
When the osmolarity is equivalent to plasma
Hypertonic
When the osmolarity is greater than plasma. Hypertonic fluids pull water from the cells and into the intravascular spaces.
Hypotonic
When the osmolarity is less than plasma. Hypotonic fluids move from the intravascular space to the ICF
Normal Saline
Isotonic Solution. Treat hypovolemia, hyponatremia, hypercalcemia, metabolic alkalosis.
Lactated Ringers (LR)
Isotonic Solution. Contains multiple electrolytes. Lacks magnesium. Treats hypovolemia, burns, and GI losses
5% Dextrose in Lactated Ringers (D5LR)
Hypertonic Solution. Replaces electrolytes, provides calories, shifts fluids from cells to vascular space expanding vascular volume
Half strength normal saline (0.45%NaCl)
Hypotonic Solution. Often used as a maintenance fluid. Provides Na Cl and free water
Fluid Intake methods
ingested water, ingested food, metabolic oxidation
Fluid Output methods
kidneys, skin, lungs, gastrointestinal
Kidneys
Filter 180 L of plasma/day while excreting ~1.5 L/day. Manage ECF volume and osmolality. Regulates electrolyte levels by retaining or eliminating.
Heart & Vascular
Circulate fluid, adequate perfusion pressure in kidneys for filtration. Stretch receptors respond to changes in volume and stimulate fluid retention when hypovolemia is present
Heart & Vascular
Circulate fluid, adequate perfusion pressure in kidneys for filtration. Stretch receptors respond to changes in volume and stimulate fluid retention when hypovolemia is present
Lungs
Water vapor excreted/lost per day: 300mL/day
Nervous System
Osmoreceptors (type of neuron) sense changes in ECF concentration and stimulate the pituitary gland to release or inhibit release of ADH. Thirst center in the hypothalamus is activated by cellular dehydration
Gastrointestinal Track
Absorbs water and nutrients
Adrenal Glands
- Aldosterone secretion causes sodium (and
water) retention and potassium loss - Excess cortisol secretion can cause the same
effect as aldosterone
Pituitary Gland
Manages antidiuretic hormone (ADH)
* ADH allows the body to retain water
* ADH in increased when osmotic pressure of
ECF is greater than that of the cells, when
blood volume is decreased
* ADH is suppressed when osmotic pressure
of the ECF is less than that of the cells, or
when blood volume is increased
Thyroid Gland
- Thyroxine secretion least to increased blood
flow, including to the kidneys , whey increases
filtration rate and urinary output
Thyroid Gland
- Thyroxine secretion least to increased blood
flow, including to the kidneys , whey increases
filtration rate and urinary output
Parathyroid Gland
- Regulates calcium and phosphate balance
through parathyroid hormone (PTH) - PTH influences bone reabsorption, calcium
absorption from the intestines and calcium
reabsorption from the kidneys - Increased PTH cases increased blood
(serum) calcium and deceased phosphate;
and decreased PTH cases decreased
calcium and increased phosphate
Interstitial excess
edema
Intravascular excess
hypervolemia
Acidis/Third Spacing
Fluid moves into transcellular compartments (pleural,
peritoneal, pericardial, joints, bowel,) or interstitial spaces. Causes hypovolemia (fluid is unavailable for use)
hyponatremia
Not enough Sodium. Nausea, vomiting, muscle cramps, hypotension, edema, weakness, confusion, lethargy, twitching, seizures, coma
Hypernatremia
Too much sodium. Thirst, dry mucous membranes, hallucinations, lethargy, seizures, coma
Hypokalemia
Not enough potassium. Fatigue, anorexia, nausea, committing, muscle weakness, decreased bowel motility, cardia arrhythmias, paresthesia, postural hypotension, EKG changes
Hyperkalemia
Too much potassium. Vague muscle weakness, cardia arrhythmia, decreased excitability of the heart. Paresthesias of face, tongue, feet, and hands
Hypomagnesemia
Not enough magnesium. Neuromuscular irritability, increased reflexes, coarse tremors, seizures, cardiac manifestations=tachyarrhythmias, increased susceptibility to digitalis toxicity, disorientation, mood changes
Hypermadnesemia
Too much magnesium. Hypotension, flushing, drowsiness, decreased reflexes
Hypocalcemia
not enough calcium. Increased excitability of muscles and nerves (cardiac arrhythmias) trousseau and Chvostek signs, numbness and tingling of fingers and toes, mental changes, cramps in musles
Hypercalcemia
too much calcium. Muscle weakness, tiredness, lethargy, constipation, decreased memory, kidney stones, cardiac arrest
Chvostek’s sign
tapping on facial nerve just anterior to the ear produces tetany (inoluntary twitching on the
ipsilateral (same) side of the patients face/upper lip). Tests for hypocalcemia
Trousseau Sign
Inflate a BP cuff above NSBP range. Positive response in a patient with hypocalcemia is a wrist, metacarpal and phalangeal/thumb flexion. Tests for hypocalcemia
Hypophosphatemia
not enough phosphate. Respiratory failure, seizures, decreased tissue oxygenation, joint stiffness, increased risk for infection
Hyperphosphatemia
Tetany (tingling of fingers, mouth, numbness, spasms) long term can lead to calcification of soft tissues
Hypovolemia
loss of both fluids and solutes from the extracellular spaces. Leaves interstitial space to be hypertonic resulting in cells without adequate fluid to function
5% weight change is considered a deficit
15% weight change is considered life threatening
Onset, Peak, and Duration of Rapid-Acting insulin
O=15-30m
P=30m-2.5h
D=3-6h
Onset, Peak, and Duration of short-Acting insulin
O=30-60m
P=1-5h
D=6-10h
Onset, Peak, and Duration of intermediate-Acting insulin
O=1-2h
P=4-12
D=16h
Onset, Peak, and Duration of long-Acting insulin
O=3-4h
P=continuous
D=24h
Digoxin
Anti-Arrhythmic. Toxicity: monitor digoxin level (nausea, vomiting. Visual disturbances, bradycardia. Assess apical pulse for 1 minute. Hold if rate is under 60bppm
Aspirin
Antipyretic, non-opioid analgesic
Aspirin Side Effects
Prolongs bleeding time
Toxicity: tinnitus, agitation, confusion, GI bleed
Do not crush. Enteric coded
Take with a full glass of water and sit up for 15-30m
Avoid Alcohol
Furosemide
Loop Diuretic
Furosemide Considerations
Consider hypovolemia. Won’t hold K+.
Toxicity=tinnitus
Give am. Last dose no later than 17:00
Ototoxic (hearing loss) if given rapidly through IV.
Warfarin
Anti-Coagulant
Warfarin Considerations
Antidote=SQ Vit K
Monitor labs=PT/INR=2-3=how quickly is blood clotting?
Monitor for s/s of bleeding=use electric razor
avid food high in K+
consult PCP before starting new medications or OTC medications due to interaction lists
Prednisone
Corticosteroid (antiasthmatic)
Prednisone Considerations
monitor electrolytes (hypokalemia) and glucose (hyperglycemia)
cannot stop suddenly
administer in am with meals.
Nitrogylcerin transdermal
Anti-angina-vasodilator
Nitrogylcerin transdermal Considerations
monitor HR and BP=hypotension. Watch orthostatic hypotension
Remove patch before reapplying new patch. rotate patch application site
Headache common side effect
contraindication: verify if patient is taking erectile dysfunction medications
remove before MRI, cardio version or defibrillation
Sertraline
SSRI (selective serotonin reuptake inhibitor)
Sertraline Considerations
careful suicide assessment
avoid alcohol and other CNS antidepressants.
Photosensitivity
metoprolol
Beta-blocker, antihypertensive
metoprolol consideration
monitor BP and HR. Monitor EKG periodically and during adjustments
assess apical pulse for 1 minute: hold if HR is less than 60HR or Systole of less than 90
Metformin
Antidiabetic
Metformin Considerations
Do not crush=extended release
monitor serum glucose and glycosylated hemoglobin levels
Contraindications: IV contrast procedures=stop taking at time of test and alert for 48hrs
Enoxaparin
Anticoagulant, antithrombotic
Enoxaparin Considerations
prefilled syringe: do not expel the air
can be given for 7-14 days
Antidote: protamine sulfate
Avoid ASA, NSAIDS
Monitor stool for occult blood
Morphine Sulfate and Hydromorphone
opiod
Morphine Sulfate and Hydromorphone Considerations
Given IVPB
More potent that morphone sulfate
Antidote=narcan
monitor HR or BP
two nurses verification for discarding
Heparin Infusion
Anticoagulant
Heparin Infusion Considerations
Monitor labs during IV infusion
PTT or aPTT: blood viscosity test for heparin
antidote: protamine sulfate
Can be given sub cue
Routine
carried out until canceled by a physician
Standing
Carried out if/when the circumstances exist
PRN
given when Pt. requires it
Single doses
given only one time
STAT:
given immediately
Telephone or verbal order
only acceptable in emergency situations–write down and perform a read back
Medication reconciliation
review of all medications that the patient took before they reached you. Then medications are reconciled each time the patient changes care areas.
Triple Check
Visually confirm the medication three times:
At reach
In hand (med/dose)
One last time before administration
Three Checks:
Check the medication order
Check pt. Allergies
Check expiration date
Six Rights
Right drug, right dose, right route, right time, right patient, right documentation