EXAM 2 Review Content Flashcards
What is an oxygen cylinder’s max pressure and volume
2,000psi and 660L
What is a Nitrous Oxide cylinders max pressure and volume
745psi and 1590L
What is a Nitrous Oxide cylinders max pressure and volume
745psi and 1590L
When is the spill valve open and closed
Closed during inspiration
Open during expiration
The transfilling valve, aka yoke hanger check, aka check valve/outlet check valve, has what function:
Prohibits trans filling of other cylinders
The O2 flush valve delivers oxygen at what pressure and volume
50psi
35-75L
Describe this TEG
Normal
Describe this TEG
Anticoagulation or Factor Deficiency
Describe this TEG
Reduced platelet count or function
Describe this TEG
Primary Fibrinolysis
Describe this TEG
Hypercoagulation
Describe this TEG
DIC Stage 1: hypercoagulable state with secondary fibrinolysis
Describe this TEG
DIC Stage 1: hypercoagulable state with secondary fibrinolysis
Describe this TEG
DIC Stage 2: HyPOcoagulable state
In the brain, what is going to determine if fluid stays in the vasculature/pulls into the vasculature or pushes into the interstitium?
Blood-Brain Barrier
Sodium is less permeable. Making it the primary determinant over plasma proteins.
You give an isotonic solution into the intravascular space. What is going to happen to that solution?
A portion will stay in the intravascular space, but a portion of it, in about 30min, ~75%, will be lost to the interstitial space to reach equilibrium.
HESes are associated with?
Could you pick out what they are not associated with?
Kidney injury
Dialysis requirements
coagulopathy
sepsis
and increased mortality
What would be some reliable means for determining where your patient is on the Frank-Starling Curve?
● Edema, turgor, mucous membranes, cap refill, auscultate (hands on assessment)
● Pulse contour analysis (PPV >13% fluid responsive, <8% pressor responsive)
● NOT CVP, MAP OR UO
What might happen if you did a volume resuscitation with Normal Saline?
Hyperchloremia - Metabolic Acidosis
If you hypoventilated a patient - what would that do to your acid-base balance? Therefore, what would it do to your electrolytes?
Create respiratory acidosis –> more calcium and potassium shifts or is released into intravascular fluid.
You need to do an emergent C-Section on an eclamptic patient; what anesthetic drug has an increased risk profile in that circumstance?
(typically because of an electrolyte abnormality)
Magnesium potentiates the effects of Nondepolarizing neuromuscular agents. May need extra reversal agent.
Stop mag and reverse with CaCl
If you need to expand the plasma volume in a patient with a traumatic head injury, what fluid would you pick?
Hypertonic Saline Solutions of 3% or greater.
Promote volume expansion that mobilize intracellular and interstitial fluid into the vascular space. May protect patients with intracranial hypertension.
Fluid in the capillary bed going from the capillary side to interstitial or interstitial to the capillary. What changes would you expect if the patient had a low cardiac output state?
Acute drop in CO due to anesthesia will drop capillary hydrostatic pressure. Creating a net negative pressure pulling fluid INTO the intravascular space.
Calculate a maintenance fluid rate using the 4:2:1 rule.
4ml/kg for the first 10kgs
2ml/kg for the second 10kg
1ml/kg for the remaining
If greater than 20kg, add 40 to find the maintenance rate
If you needed to devise a fluid plan for a hypovolemic patient, what fluid would you choose?
Isotonic: LR or NS
Your patient is going to have surgery; they’re going to have an incision; what things can lead to evaporative losses?
Sweat, Breathing, Surgical exposure of body cavaties
Your patient has Hyperkalemia and you have these EKG changes: Loss of P wave and widening QRS; immediate effective therapy is indicated, what do you administer?
- IV Calcium Chloride - 10mL of 10% CaCl over 10-min period
or
10mL of 10% Calcium Gluconate over 3-5min - IV Sodium Bicarb, 50-100mEq over 10-20min
Which yields more ionized calcium, CaCl or CaGluconate?
CaCl = 27mg/mL
Gluconate = 9mg/mL
What is the onset of Calcium Chloride or Calcium Gluconate?
1-3 minutes
What is the duration of action of Calcium Chloride or Calcium Gluconate?
30-60minutes
Why give calcium for hyperkalemia?
Stabilizes cardiac membrane
Bicarbonate administration for Loss of P wave and widening QRS due to hyperkalemia takes how long to take effect?
5-10minutes
Bicarbonate administration for loss of P wave and widening QRS due to hyperkalemia lasts for how long?
1-2 hours
Bicarbonate administration for Loss of P wave and widening QRS due to hyperkalemia has what mechanism of action?
Shifts potassium intracellularly
Your patient has hyperkalemia and Peaked T waves that need prompt therapy; what do you do?
- Glucose and Insulin Infusion:
IV of 50mL D50W and five units regular insulin - Urgent hemodialysis
Administration of IV D50W 50mL and five units regular insulin for hyperkalemia takes how long to onset?
30 minutes
Administration of IV D50W 50mL and five units of regular insulin for hyperkalemia has a therapeutic duration of?
4-6 hours
What is the mechanism of action of glucose and insulin administration in a hyperkalemic patient?
Shifts potassium intracellularly.
What should you do if the patient has hyperkalemia but no EKG changes?
- Administer potassium-binding resins in GI tract
- Promotion of renal excretion via loop diuretics.
How long does oral potassium binding resins take to onset? Have a duration of?
Onset: 1-2 hours
Duration: 4-6 hours
Administration of furosemide 40mg for hyperkalemia usually has an onset of? And a duration of?
Onset: 15-30 minutes
Duration: 2-3 hours
Pts who should not receive colloids/albumin:
Neurotrauma
Endothelial injuries / impaired glycocalyx —> pulm edema, end-organ damage (Sepsis, Lg Vascular Traumas)
Hypocalcemia
Hyperglycemia (DM)
Pts who can receive colloids:
-Volume loss not from active bleeding
-Hypovolemic pts with Intact glycocalyx
- Pts with lower capillary oncotic pressure such as liver pts with
hypoalbuminemia
The causes of OR fires are primarily from?
Electrocautery - 90%
Lasers - 10%
What percent of OR fires occur during high risk cases involving the head, neck, and upper chest?
85%
What percent of OR fires involve the airway? Head and Neck?
34% airway
28% head and neck
If you know or suspect patient inhalation injury from toxic fumes: ex - CO, HCL, Cyanide - the patient is at risk for? What should your actions be?
At risk for airway edema. Look quickly, if any indication, including airway/voice hoarseness, intubate immediately.
You can always extubate later the same day.
What are the three components of the fire triangle?
Fuel Source
Ignition Source
Oxidizer
What are some Fuel Sources in the OR
surgical prep and alcohol [Allow to dry!]
petroleum ointments, facial hair, drapes, gloves, breathing circuits, dressings, ETT
What are some Ignition Sources in the OR
ESUs, fiberoptics, high-speed drills, laser, monitors, defibs, desiccated soda lime
What are some Oxiders in the OR
Air, O2, N2O
in 95% of cases it is O2 because it is heavier than air, and it accumulates around and under drapes
What are some surgical fire prevention strategies
-Avoid open air O2 delivery. ETT (closed) or LMA (less closed but more than open)
-Communicate fire sources and if O2 requirements are raising in ESU cases
-Coat facial hair with water-soluble lubricant
-Laser resistant ETTs
-Moistened sponges
-Flame retardant drapes
When using O2 in an ESU procedure. The supplemental O2 should be less than what % and off for how many minutes before ESU use?
Less than 30% and off for 1min prior
Anesthesia providers are responsible for what portion of the fire triangle
Oxider
What steps should be taken if an airway fire occurs?
- Stop ventilation and remove ETT
- Stop flow of all gases
- Remove all other flammable material away from airway
- Pour water or saline into airway
- Fire extinguisher if water did not clear fire (BC extinguisher)
- Assess for airway edema / trauma
- Consider steroid admin
- Monitor in ICU for 24 hours
- Report to joint commission and FDA
To avoid a blow torch effect, what should you NOT do when extubating the patient because of an airway fire?
do not squeeze the reservoir bag
Why do O2 devices ignite easily?
They contain polyvinyl chloride (PVC)
What does RACE stand for
Rescue
Alarm
Contain
Extinguish
What does P.A.S.S. stand for
Pull pin
Aim at base of fire
Squeeze
Sweep side to side
Laser light differs from ordinary light because of what three things:
- Monochromatic - single wavelength
- Coherent - light oscillates in the same phase
- Collimated - exists as a narrow parallel beam
Long wavelength lasers absorb _____ ____ and (do or do not) penetrate deep into tissue
Absorb more water and do NOT penetrate deep into tissue
Short wavelength lasers absorb _____ ____ and (do or do not) penetrate deep into tissue
less water and DO penetrate deeper into tissue
CO2 lasers require what color eye protection to protect which eye structure
Clear lenses - cornea
Nd:YAG lasers require what color eye protection to protect which eye structure
Green goggles - Retina
Ruby lasers require what color eye protection to protect which eye structure
Red goggles - Retina
Argon lasers require what color eye protection to protect which eye structure
Amber goggles - Retina
The decision to transfusion PRBC should be based on?
Insufficient DO2 (oxygen delivery)
Hg <6 (almost always); Hg <7 (depends); you are transfusing RBC’s to improve DO2: arterial oxygen delivery, mixed venous, central venous oxygen sat; transfuse if there’s signs of improper DO2: lactate levels, signs of cardiac ischemia: hypotension, tachycardia
Describe the differences between:
Type
Screen
Cross
Type: ABO and Rh status.
Screen: Screens for more rare antibodies. [45min]
Cross: “test transfusion” mixes donor blood and patient blood. It greatly reduces the likelihood of transfusion rxn. [45min]
What are 5 procoagulants
Coagulation Factors
Collagen
vWF
Fibronectin
Thrombomodulin
What are 4 AntiCoagulant mediators?
AntiThrombin III
Protein C
Protein S
Tissue Pathway Factor Inhibitor
What are two vasodilatory mediators
Nitric Oxide and Prostacyclin
What are three vasoconstrictor mediators
Thromboxane A2
ADP
Serotonin
What are three fibrinolytic mediators?
Plasminogen
tPA (tissue plasminogen activator)
Urokinase
What kind of mediator is Plasminogen classified as? :
What is its function?
Fibrinolytic
Converts to plasmin
What kind of mediator is tPA classified as? :
What is its function?
Fibrinolytic
Activates plasmin
What kind of mediator is Urokinase classified as? :
What is its function?
Fibrinolytic
Activates plasmin
What are two anti-fibrinolytics?
Plasminogen Activator Inhibitor
alpha-antiplasmin
What kind of mediator is Plasminogen Activator Inhibitor
What is its function?
Antifibrinolytic
Inactivates tPA and urokinase
What kind of mediator is alpha-antiplasmin classified as? :
What is its function?
Antifibrinolytic
Inhibits Plasmin
What factors make up the Extrinsic Pathway
Factor 3 - Tissue Factor (Thromboplastin)
Factor 7 - Proconvertin Factor (labile)
Vitamin K is created by? And is it necessary for the formation of which factors?
Created from bacteria in the gut and is necessary for the formation (in the liver) of Factors 2, 7, 9, 10
What are two antifibrinolytic (anticlot breakdown) medications?
Aminocaproic Acid
Tranexamic Acid (TXA)
The PT lab value will be prolonged when patients have abnormalities or deficiencies in?
factors specific to the extrinsic (3 & 7) and common pathways (10, 9?, 2, 1)
What is a normal INR?
Apex: ~1
Nagelhout: 1.5-2.5
aPTT is used to evaluate the efficiency of the ____ and the common coagulation pathway. This includes which factors?
Intrinsic: 12, 11, 9, and 8
Common: 10, 5, 2, 1 and ultimately 13
Normal ACT
Apex: 90-120
Nagelhout: 90-150
ACT is used to measure?
Activated Clotting Time. Ability to clot. Also can be used to regulate heparin therapy.
TEGs provide an indication of what 5 processes?
- Clot Strength
- Platelet number and function
- Intrinisic Pathway defects
- Thrombin formation
- Rate of fibrinolysis
What are four very high risk for bleeding procedures? What should the minimum platelet count be?
Neurosurgery
Ocular surgery (except cataracts)
Thyroid Surgery
Prostatectomy
75,000-100,000 plts
What is the MABL (maximum allowable blood loss) equation?
MABL = EBV x (Starting Hct(or hgb) - Minimum acceptable Hct(or hgb) ) / all of the above divided by initial hematocrit (or hgb) level
Which blood product carries the greatest risk for bacterial transmission?
platelets
Fresh Frozen Plasma (FFP) contains?
All coagulation factors, especially factors 2, 7, 9, and 10
AND
Albumin (plasma proteins)
Fibrinogen
[Antithrombin 3, Protein C and S (hemostasis equilibrium)]
What lab values may indicate you should administer FFP?
PT and/or aPTT prolonged more than 1.5 times normal.
(FFP=Factors 2,7,9,10. Albumin. Fibrinogen.)
Long INR
Cryoprecipitate contains?
Factor 8 and 13.
Fibrinogen
vWF
Fibronectin
Describe Type 1 and 2a vWF disease and how you would treat it before surgery?
Mild-moderate reduction in vWF production. Treated with Desmopressin (0.3mcg/kg)
Cryo if there is no response or availability of Factor 8 concentrate.
Describe Type 2b and 3 vWF disease and how you would treat it before surgery?
vWF is not produced or doesn’t work correctly.
Bleeding patients with type 3 should be given vWF/Factor 8 concentrate or Cryo.
Desmopressin will not work.
What coagulation lab values would you expect in a patient with Hemophilia A? What would be the treatment before surgery?
PTT increased and PT normal
Mild - can try DDAVP (vWF carries factor 8 around)
Factor 8 Concentrate before surgery
Cryo (has more Factor 8) > FFP
Recombinant Factor 7 last-ditch effort
What coagulation lab values would you expect in a patient with Hemophilia B? What would be the treatment before surgery?
PTT increased and PT normal. Remember Factor 9 is on intrinsic pathway.
Factor 9 - Prothrombin Concentrate Complex
FFP
Recombinant Factor 7 last-ditch effort
NOT desmopressin. Has no effect on Factor 9
Lab Values Consistent with DIC
Decreased Platelets [less than 100]
Decreased Fibrinogen [under 150]
Decreased AntiThrombin [less than 80%]
Increased D-Dimer [over 500]
Increased PT[over 14] or aPTT[over 32]
What is the universal FFP donor and acceptor?
Donor: AB
Acceptor: O
Pt needs surgery. You have a patient taking Warfarin, INR is high, what do you do?
If you have time: Vitamin K to reverse (takes a few hours)
If it’s emergent: FFP or Prothrombin Complex Concentrate
What extrinsic factor is produced in the liver?
Factor 7
Produced in the liver. Vitamin K required for synthesis