Exam 2: Respiratory Flashcards
Functions of respiratory portion of respiratory system
Oxygen and CO2 exchange
Functions of conducting portion of respiratory system
Olfaction
Phonation
Provide defense
Condition air
3 parts of filtration system
Large particle
Medium particle
Small particle
Conducting portion
Transports air to respiratory portion
Vestibule surface epi
Keratinized strat squamous
Respiratory
Glands in vestibule
Sebaceous
Sweat
Vibrissae in vestibule acts as a
Large particle filter
Respiratory region of nasal cavity is between
Limen nasi and sup/middle concha
Functions of respiratory region of nasal cavity
Warm, clean, humidify air
Provide defense
Surface epi of respiratory region of nasal cavity
Respiratory
Mucociliary apparatus is made up of ____ and acts as ____
Goblets and ciliated columnar cells
Medium particle filter
Glands are found in ____ of respiratory region of nasal cavity
Lamina propria
Seromucous glands mucus portion contributes to
Mucociliary clearance
Air humidity
Serous part of seromucous glands produces
Lyxozyme
Interferons
Cytokines
Air humidity
Serous products acts as
Small particle filter
Also in the LP, ____ made up of many large venules (partially filled)
Cavernous plexus
Functions of cavernous plexus
Warm, humidify air
Provide defense
Increased blood flow causes venules and LP to ____ which causes lumen size to ____ which causes ____
Increase; decrease; stuffy nose
Increased blood blow causes O2 to ___ which will stimulate ____ which causes ____
Inc; seromucous gland secretion; runny nose
Olfactory region of nasal cavity surface epi
Olfactory epi
Supporting and basal cells
Olfactory neurons
Olfactory glands product a serous product to
Cleanse olfactory cilia
Epi of paranasal sinuses
Respiratory epi
Lamina propria of paranasal sinuses
Thin
Contains seromucous glands
Vascular
If small sinuses, LP swells then sinuses become ___ and _____ can occur
Blocked; sinus infection
3 subdivisions of pharynx
Nasopharynx
Oropharynx
Laryngopharynx
Surface epi of nasopharynx
Respiratory
Surface epi of oro and laryngopharynx
Strat squamous
Nasopharynx has ____ tonsils
Pharyngeal
Oropharynx has _____ tonsils
Palatine and lingual
Laryngopharynx has __ tonsils
NO
Muscularis mucosae in pharynx
NONE
Submucosa of pharynx AKA
Pharyngobasilar fascia
Collagen of occiput blends into wall of pharynx
Muscualaris externa of pharynx is all ___ muscle
Skeletal
Muscularis externa of pharynx has a ____ pattern
Reversed
Inner long
Outer circular
Adventitia of pharynx AKA
Buccopharyngeal fascia
Epimysium of buccinator blends into adventitia of pharynx
Surface epi of larynx
Strat squamous (upper), transition to respiratory
LP of larynx
Looser CT w/ seromucous glands
Functions of cartilages in larynx
Maintain open airway
Aid sound production
Hyaline cartilage makes up
Thyroid cartilage
Cricoid cartilage
Inferior arytenoid cartilage
Elastic cartilage makes up
Cuneiform cartilage
Corniculate cartilage
Superior arytenoid cartilage
Epiglottis
Function of epiglottis
Keep food/liquid out of larynx
Surface epi of epiglottis
Upper = strat squamous Under = respiratory
Vestibular folds surface epi
Respiratory epi
Vestibular folds LP
Loose CT
Seromucous glands
Lymph nodules
Laryngeal ventricle surface epi
Strat squamous
Vocal folds surface epi and function
Strat squamous
Protect from abrasion/drying
LP of vocal folds and function
Dense regular bundles of elastic CT
Support free edge of vocal fold
Vocalis muscle
Striated muscle
Deep to mucosa of larynx
Surface epi of trachea
Respiratory epi
Cells of respiratory epi of trachea
Goblet = 30% Ciliated columnar = 30% Basal = 30% Brush cells = 3% Serous cells = 3% DNES cells = 3-4%
Function of brush cells in trachea
Chemosensory — monitor air quality
Function of serous cells in trachea
Secrete product into lumen (product unknown)
DNES — diffuse neuroendocrine cells function
Secrete in LP
LP of trachea
Loose CT w/ seromucous glands
Quite vascular
Muscularis mucosa in trachea
NONE
Submucosa of trachea contains ____ that blends with ___
Hyaline cartilage C ring; LP
Muscularis externa in trachea
Trachealis muscle
Adventitia in trachea is
CT
Extrapulmonary bronchi is structurally similar to
Trachea
Bronchi have more
Smooth muscle
Elastic CT
Bronchi have decreased amounts of
Cartilage
# of glands and goblet cells
Height of epi
Extrapulmonary bronchi includes
Primary bronchi
Intrapulmonary bronchi includes
Lobar and segmental bronchi
Bronchioles are characterized by
No cartilage or seromucous glands
Complete layer of sm ms
Epi of bronchioles
Ciliated columnar w/ some goblets and clara cells
Clara cells have short ___
Microvilli
Clara cells are _____ in surface epi of brochioles
Secretory cells
Clara cells secrete ____ and produce ____
Lyxozyme; surfactant-type material
Clara cells regenerate
Bronchiolar epi
Terminal bronchioles
Last part of conducting portion of respiratory system
Epi of terminal bronchioles
Ciliated simple columnar/cuboidal w/ clara cells
LP of terminal bronchioles
Fibroelastic CT
Respiratory bronchioles are the first region of
Respiratory portion of respiratory system
Epi of respiratory bronchioles
Simple cuboidal epi w/ clara cells and cilia
Epi of respiratory bronchioles has some _____ therefore ____ is possible
Simple squamous; gas exchange
Function of alveolar ducts
Gas exchange
Function of alveolar sacs
Gas exchange
Function of alveoli
Gas exchange
MC cell types in alveoli
Alveolar type I
Alveolar type II
Alveolar macrophage
Alveolar type I make up about ___% of alveolar surface
95
Alveolar type I is made up of squamous type cells w/
Zonula occludens
Functions of alveolar type I
Gas exchange
Alveolar type II pneumocyte makes up about ___% of alveolar surface
5%
Alveolar type II cells are ___ shape
Cuboidal
General functions of alveolar type II cells
Stem cell for alveolar cells
Produce pulmonary surfactant
Produce lysozyme
Alveolar macrophages develop from
Monocytes
General function of alveolar macrophage
Clean septal walls using phagocytosis
Produce lysozyme
Interalveolar septum parts
Alveolar type I/II cells
Continuous capillary
Basal lamin
Little CT w/ lots of elastic fibers
Blood-gas barrier is a region where
O2 and CO2 pass btw air and blood
Parts of blood-gas barrier
Pulmonary surfactant
Alveolar type I cell
Fused basal lamina
Endo cells of capillary
Fused basal lamina is shared btw
Alveolar type I cell
Endo cell of capillary
Blood gas barrier is the minimum _______that allows for most efficient gas exchange
Diffusion distance/barrier
Respiratory distress of newborn caused by
Too few mature alveolar type II cells
Emphysema is caused by
Dec in elastin — dec alveolar elasticity
Reduced surface for gas exchange
Inflamm attracts macrophages and neutrophils which secrete
Elastase
Alpha 1 antitrypsin is a protein that protects ___ and is produced by ___
Elastic fibers; hepatocytes
Chemical in cig smoke can inactivate
Apha 1-AT
Genetic condition for emphysema
Hepatocytes produce alpha 1 AT but can’t release it
Lung cancer: squamous cell carcinoma
Develops from epi in segmental bronchi
Adenocarcinoma often develops from
Epi in alveoli and bronchioles
Small cell carcinoma often develops from
Small granule DNES cells in bronchi