Exam 2 Prep - ABX

Question 1

Which classes of antibiotics act by weakening the cell wall?

Answer 1

Penicillins

Cephalosporins

Carbapenems

Vancomycin

Question 2

Which classes of antibiotics are bacteriostatic inhibitors of protein synthesis?

Answer 2

Tetracyclines

Macrolides

Clindamycin

Linezolid

Question 3

Which classes of antibiotics are bactericidal inhibitors of protein synthesis?

Answer 3

Aminoglycosides

Question 4

Which classes of drugs act by altering folate synthesis?

Answer 4

Sulfonamides

Trimethoprim

Question 5

Narrow Spectrum Penicillinase-Sensitive Penicillins include:

Answer 5

Penicillin G

Penicillin V

Question 6

Narrow Spectrum Penicillinase-resistant Penicillins include:

Answer 6

Nafcillin

Oxacillin

Dicloxacillin

Question 7

Broad spectrum penicillins include:

Answer 7

Ampicillin

Amoxicillin

Question 8

Extended-spectrum penicillins include _____ and are effective against _____

Answer 8

Piperacillin

Gram Negative (antipsuedamonal)

Question 9

1st Generation Cephalosporins include:

Answer 9

Cephalexin (keflex)

Cefazolin (ancef)

Cefadroxil

Question 10

Fifth generation cephalosporins include:

Answer 10

Ceftaroline

Question 11

TETRACYCLINES

ACTION & DRUG LIST

Answer 11

PROTEIN SYNTHESIS

• Tetracycline
• Demeclocycline
• Doxycycline
• Minocycline

Question 12

MACROLIDES

ACTION & DRUG LIST

Answer 12

Protein Synthesis

• Erythromycin
• Azithromycin
• Clarithromycin

Question 13

CLINDAMYCIN

ACTION & NUGGETS

Answer 13

Bacteriostatic Protein Synthesis

• Causes CDiff
• Hepatotoxic
• Doesn’t cross BBB

Question 14

LINEZOLID

ACTION & NUGGETS

Answer 14

bacteriostatic protein synthesis

• VRE/MRSA
• DO NOT TAKE WITH MAOIS OR SSRIS

Question 15

AMINOGLYCOSIDES

ACTION & DRUG LIST

Answer 15

Bactericidal Protein Synthesis

• Gentamycin
• Amikacin
• Tobramycin
• Neomycin

Question 16

BACTRIM

MOA & NUGGETS

Answer 16

Folic Acid Synthesis Inhibitor

• Sulamethoxazole & Trimethoprim
• Lots of drug interactions (Warfarin and Dilantin)
• Megaloblastic anemia (folate deficiency)

Question 17

FLOUROQUINOLONES

ACTION & DRUG LIST

Answer 17

Disrupts DNA and RNA synthesis

• Ciprofloxacin
• Ofloxacin
• Levofloxacin
• Metronidazole

Question 18

Which cephalosporins cause alcohol intolerance?

Answer 18

Cefotetan and Cefazolin

Question 19

Which cephalosporins can cause bleeding tendencies?

Answer 19

Cefotetan and Ceftriaxone

Question 20

Each generation of cephalosporins becomes increasingly ______

Answer 20

• Active against gram (-)
• resistance to beta lactamases
• able to reach the CSF

Question 21

Which generation of cephalosporins are the preferred treatment for meningitis?

Answer 21

Third (Ceftriaxone/Rocephin)

Question 22

Which carbapenem is active against MRSA?

Answer 22

None of them

Question 23

Which antibiotic interacts with Valproate?

Answer 23

Imipenem

Question 24

Which class of antibiotics tends to cause seizures?

Answer 24

Carbapenems

Think: Kind of sounds like carbamazepine

Question 25

What are the four major AEs of Vancomycin?

Answer 25

1. Red Man Syndrome
2. Nephrotoxicity
3. Ototoxicity
4. Thrombocytopenia

Question 26

What is the MOA and uses of Fosfomycin?

Answer 26

Cell wall synthesis

UTIs

Question 27

What are the two big ticket drugs that interact with tetracyclines?

Answer 27

Warfarin (increases Vit K)

Digoxin (increases levels)

Question 28

Which antibiotic should absolutely never be taken with MAOIs or SSRIs?

Answer 28

Linezolid

Question 29

What is the treatment of choice for a patient taking aminoglycosides that has developed neuromuscular blockade?

Answer 29

Calcium gluconate

Question 30

Which antibiotic should never be given to a patient with MG?

Answer 30

Fluoroquinolones

Question 31

Which three drugs are used to eradicate H. Pylori?

Answer 31

1. Flagyl
2. Tetracycline
3. Bismuth

Question 32

All the first line TB drugs are bactericidal EXCEPT:

Answer 32

Ethambutol