4 - Anti-Inflammatory Flashcards
The family of COX inhibitors includes:
Aspirin and all of its related drugs
Only one COX inhibitor can protect against MI and stroke:
Aspirin
What is cyclooxygenase?
the enzyme responsible for synthesizing prostaglandins from Arachidonic Acid
What is the role of COX at sites of tissue injury?
catalyzes the synthesis of PGE2 and Prostacyclin
promotes inflammation and sensitizes pain fibers
What is the role of COX in the stomach?
PGE and prostacyclin to protect the gastric mucosa
What is the role of COX in platelets?
promotes synthesis of TXA2, which stimulates platelet aggregation
What is the role of COX in blood vessels?
promotes synthesis of prostacyclin, which causes vasodilation
What is the role of COX in the kidney?
synthesis of PGE and prostacyclin promote vasodilation and maintain renal blood flow
What is the role of COX in the brain?
prostaglandins mediate fever and contribute to perception of pain
What is the role of COX in the uterus?
prostaglandins help promote contractions at term
Where do you prostaglandins, TXA2, and prostacyclin act: locally or systemically
they all ONLY act locally!
Which COX is found in the stomach and on platelets?
COX 1
Which COX is responsible for kidney perfusion?
Both
Which COX is found in injured tissue?
COX 2
Which COX has actions in the brain?
COX 2
There is only one irreversible COX inhibitor:
Aspirin
Aspirin will halt a fever, but it will not decrease temperature that has become elevated in response to physical activity or environmental temperature. Why?
ASA targets set-point elevation, not temperature elevation
Prostaglandins that are created in response to endogenous pyrogens are responsible for increased set point, and ASA inhibits their production
The life of a platelet is about ______
8 days
What should you do if you have a patient who needs Aspirin but is at risk for developing an ulcer?
Prophylactic PPI
How does aspirin effect stroke likelihood?
Makes an ischemic stroke less likely
Makes a hemorrhagic stroke more likely in patients with BP > 150/90
What are the signs of Salicylism?
Tinnitus
Sweating
Headache
Dizziness
Respiratory Alkalosis (from increased RR)
Use of _______ in children young than 18 is associated with Reye Syndrome
Aspirin
What are characteristic symptoms of Reye Syndrome?
Encephalopathy
Fatty Liver Degeneratio
Why is it dangerous to give ASA and glucocorticoids?
Both are very hard on the stomach
risk of gastric ulceration is very high when they’re given together
