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MBB > Exam 2 pathology > Flashcards

Exam 2 pathology Flashcards

1
Q

What is the picture on the right and left? Describe abnormal histology and pathology

A

Left = normal brain tissue and normal brain histology

Right= infiltrative glioma, increased cellularity and decreased differentiation of junctions between gray and white matter

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2
Q

Grade each histology slide with WHO grading, what type of neoplasm are these?

A

gliomas

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3
Q

What is this

A

Glioma-anaplastic astrocytoma

white arrow = mitotic figure

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4
Q

What is this?

A

GBM ring enhancing butterfly lesion- crosses midline

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5
Q

What is this?

A

GBM ring enhancing lesion

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6
Q

What is this?

A

crosses midline at arrow

GBM- butterfly lesion

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7
Q

Charateristics of GBM

A
  • VERY MALIGNANT (doesn’t metastasize)
  • •Pseudopalisading necrosis, vascular proliferation
  • poor prognosis (grade IV)
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8
Q

What is this?

A

GBM-Pseudopalisading Necrosis

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9
Q

What is this?

A

GBM-Vascular Cell Proliferation

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10
Q
A
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11
Q

What is this?? What is the treatment?

A

Primary CNS lymphoma

-atypical lymphocytes clustering around blood supply

Tx: Steroids

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12
Q

What is this? What part of the brain is it in?

A

pediatric- cyst with mural nodule (upper white part of cyst) in the posterior fossa

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13
Q

What is this?

A

Meningioma with chararistic dural tail

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14
Q

What is this?

A

Shwannoma-verocai bodies

-if on vestibular branch of CN 8= acoustic neuroma (bilateral=NF2)

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15
Q

What is this?

A

Schwannoma (acoustic neuroma) - affecting CN8 by entering auditory canal

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16
Q

NF2

A

Chromosome 22 affected

MISME syndrome

  • Multiple Inherited
  • Schwannomas
    • esp. bilateral vestibular nerve
  • Meningiomas
  • Ependymomas
    • esp. spinal
    • other gliomas
17
Q

NF1 (aka von Recklinghausen disease)

A

chromosome 17

  • neurofibromas
  • Malignant peripheral nerve sheath tumor (MPNST)
18
Q

diagnosis?

19
Q

diagnosis?

20
Q

What is this?

A

Adenoma Sebaceum (hamartoma on face)

Manifestation of Tuberous Sclerosis

21
Q

What is this?

A

Cortical Tuber

Tuberous Sclerosis manifestation

22
Q

What is this?

A

subependymal giant cell astrocytoma

Tuberous Sclerosis manifestation

23
Q

What genes are effected with Tuberous Sclerosis?

A

TSC1 hamartin, TSC2 tuberin

(tumor syndrome)

24
Q

Which chromosome is effected in Von Hippel-Lindau disease

What kind of tumors are characteristic of the tumor syndrome?

A

chromosome 3

Tumors: hemangioblastoma, renal cell carcinoma

25
Q

arteriole infarct

A

Lucunar infarct

26
Q

Capillary infarct

A

Caused by rickettsial infections, pathology: petechial hemorrhages

27
Q

Vein infarct

A

Dehydrated, hypercoaguable state; pathology: leptomeninges involved, bilateral lesions in cerebral hemispheres

MBB (21 decks)

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