Exam 2 pathology

Question 1

What is the picture on the right and left? Describe abnormal histology and pathology

Answer 1

Left = normal brain tissue and normal brain histology

Right= infiltrative glioma, increased cellularity and decreased differentiation of junctions between gray and white matter

Question 2

Grade each histology slide with WHO grading, what type of neoplasm are these?

Answer 2

gliomas

Question 3

What is this

Answer 3

Glioma-anaplastic astrocytoma

white arrow = mitotic figure

Question 4

What is this?

Answer 4

GBM ring enhancing butterfly lesion- crosses midline

Question 5

What is this?

Answer 5

GBM ring enhancing lesion

Question 6

What is this?

Answer 6

crosses midline at arrow

GBM- butterfly lesion

Question 7

Charateristics of GBM

Answer 7

• VERY MALIGNANT (doesn’t metastasize)
• •Pseudopalisading necrosis, vascular proliferation
• poor prognosis (grade IV)

Question 8

What is this?

Answer 8

GBM-Pseudopalisading Necrosis

Question 9

What is this?

Answer 9

GBM-Vascular Cell Proliferation

Question 11

What is this?? What is the treatment?

Answer 11

Primary CNS lymphoma

-atypical lymphocytes clustering around blood supply

Tx: Steroids

Question 12

What is this? What part of the brain is it in?

Answer 12

pediatric- cyst with mural nodule (upper white part of cyst) in the posterior fossa

Question 13

What is this?

Answer 13

Meningioma with chararistic dural tail

Question 14

What is this?

Answer 14

Shwannoma-verocai bodies

-if on vestibular branch of CN 8= acoustic neuroma (bilateral=NF2)

Question 15

What is this?

Answer 15

Schwannoma (acoustic neuroma) - affecting CN8 by entering auditory canal

Question 16

NF2

Answer 16

Chromosome 22 affected

MISME syndrome

• Multiple Inherited
• Schwannomas
  
  • esp. bilateral vestibular nerve
• Meningiomas
• Ependymomas
  
  • esp. spinal
  • other gliomas

Question 17

NF1 (aka von Recklinghausen disease)

Answer 17

chromosome 17

• neurofibromas
• Malignant peripheral nerve sheath tumor (MPNST)

Question 18

diagnosis?

Answer 18

NF1

Question 19

diagnosis?

Answer 19

NF1

Question 20

What is this?

Answer 20

Adenoma Sebaceum (hamartoma on face)

Manifestation of Tuberous Sclerosis

Question 21

What is this?

Answer 21

Cortical Tuber

Tuberous Sclerosis manifestation

Question 22

What is this?

Answer 22

subependymal giant cell astrocytoma

Tuberous Sclerosis manifestation

Question 23

What genes are effected with Tuberous Sclerosis?

Answer 23

TSC1 hamartin, TSC2 tuberin

(tumor syndrome)

Question 24

Which chromosome is effected in Von Hippel-Lindau disease

What kind of tumors are characteristic of the tumor syndrome?

Answer 24

chromosome 3

Tumors: hemangioblastoma, renal cell carcinoma

Question 25

arteriole infarct

Answer 25

Lucunar infarct

Question 26

Capillary infarct

Answer 26

Caused by rickettsial infections, pathology: petechial hemorrhages

Question 27

Vein infarct

Answer 27

Dehydrated, hypercoaguable state; pathology: leptomeninges involved, bilateral lesions in cerebral hemispheres