Exam 2 lipids

Question 1

HDL or LDL good?

Answer 1

HDL = good, want high levels
LDL= bad

Question 2

lipoprotein lipase does what

Answer 2

removes triglycerides from chylomicron

Question 3

what is main drug for cholesterol

Answer 3

statin

Question 4

what do statin drugs do?

Answer 4

they inhibit HMG-CoA reductase enzyme, thereby reducing cholesterol biosynthesis and REDUCEING LDL

Question 5

Nicotinic acid is an inhibitor of

Answer 5

hormone sensitive lipase, thereby it reduce hydrolysis of triglycerides in fat and prevents its elevation in serum

Question 6

PCSK9 inhibitor

Answer 6

an antibody that prevents LDL receptor degradation – so they can continue to suck LDL out of blood and reduce it

Question 7

what are the two omega 3 fatty acids?

Answer 7

1) EPA -eicosapentaenoic acid

2) DHA -docosahexaenoic acid

Question 8

omega 3 FA mechanism of action

Answer 8

decrease triglycerides as compared to cholesterol and inhibit the oxidation of LDL

Question 9

bile acid

Give examples of drugs

Answer 9

decrease cholesterol- 95% reabsorbed

Ex: choletyramine, colestipol, colesevelam

Question 10

statin drugs interact with what drug and do what to muscle?

Answer 10

myopathy– bc inhibit CYP3A4

interact with diltiazem (Ca+ channel blocker)

Question 11

most prescribed fibric acid drug?

Answer 11

gemfibrozil (Lopid)

- lowers VLDL which lowers triglyceride

Question 12

niacin

Answer 12

Vit B complex

- causes pruritus (itching)

Question 13

list the 3 triglyceride and 3 cholesterol lipid-altering agent

Answer 13

Triglyceride

• omega 3 FA (EPA/DHA)
• Niacin
• Fibric acids

Cholesterol

• Statin
• Bile acid sequestrants
• Ezetimibe