Exam 2 lecture 8

Question 1

Models of addiction

Answer 1

-Diagnostic model (DSM 5)
-Treatment plans
-Mechanistic models (behavioral experiment vs neurobiology

Question 2

Drive theory

Answer 2

-1950s
-Centered on positive reward
-Drugs are taken because it makes you feel good

Question 3

Opponent theory

Answer 3

-1950s
-Homeostatic setpoints are reset by repeated drug use
-When a drug is no longer taken -> away from set-point

Question 4

Disease model of addiction

Answer 4

-Addiction isn’t a choice but a disease
-Less responsibility for individual
-Treat it like a disease

Question 5

Salience theory of addiction

Answer 5

-1989
-Liking and wanting are 2 separate concepts as 2 different behavioral drive

Question 6

Classical conditioning

Answer 6

-Addiction requires the brain to learn to respond differently to subsequent drug use
-Receiving a reward is the strong way to form connections

Question 7

Long term potentiation

Answer 7

-Strengthens connections
-Glutamate cells

Question 8

AMPA

Answer 8

-Receptor
-Textbook type of ionotropic receptor
-Ion channel for Na+ ions

Question 9

NMDA

Answer 9

-Receptor
-Important for learning and memory

1. Mg2+ ion that blocks movement of ions until removed
2. Removed from A.P being fired in receiving cell
3. Na/Ca enters cell
4. Triggers making more AMPA receptors