Exam 2 lecture 12

Question 1

Pharmacokinetics alcohol

Answer 1

Administration: orally (very high concentration)

Metabolism: 95% alcohol dehydrogenase (in intestines, stomach, liver), 5% cytochrome P450

Elimination: Urine and breathing

Question 2

Pharmacodynamics alcohol

Answer 2

-GABAa receptor modulator
-NMDA receptor antagonist (learning and memory)
-L-type voltage-gated Ca2+ channel inhibited
-Agonist for endocannabinoid receptors (reward/happy)
-Intracellular pathways

-Slows down/inhibits all brain function

Question 3

Pharmacokinetic tolerance

Answer 3

-Drinking increases, enzymes increase

Question 4

Regular pharmacodynamic tolerance

Answer 4

-Fewer receptors made

Question 5

Acute pharmacodynamic tolerance

Answer 5

-More drunk at the beginning of drinking than end

Question 6

Opoids

Answer 6

-Great pain medication
-Incredibly addictive

Question 7

Opioid drugs

Answer 7

-Morphine, heroine, fentanyl

Question 8

Pharmacodynamics opioids

Answer 8

-All receptors metabotropic and inhibitory (reduced firing rates)

-Delta
-Kappa
-Mu
-Nociception

Question 9

Sensory systems

Answer 9

Opioids make sensory systems less sensative

Question 10

Pharmacokinetics opioids

Answer 10

-Absorption: Oral (slow), intravenous (fast, good high, addictive)

Metabolism: Cytochrome p450