Exam 1 Lecture 6

Question 1

Pharmaco dynamics

Answer 1

-What does a drug do at its site of action

Question 2

Ligand types

Answer 2

-Agonist
-Antagonist

Question 3

Agonist

Answer 3

Activates receptor

Question 4

Antagonist

Answer 4

-Inactivates receptor
-Competitive: Binds to regular binding site, competes with agonist
-Noncompetitive: Binds to different binding site

Question 5

Partial agonist

Answer 5

-Binds to a receptor and activates it, but not to its full effect

Question 6

Dose response curve

Answer 6

-Measures how much dose to get 50% effectiveness: ED50

Question 7

Dose response curve antagonist

Answer 7

-Stays at 0 because it inactivates receptor

Question 8

Dose response curve with agonist and competitive antagonist

Answer 8

-ED50 shift to the right
-Need more dose to reach ED50 (because fewer receptors to bind to)
-Emax is unchanged

Question 9

Dose response curve with agonist and non competitive antagonist

Answer 9

-ED50 stays
-Emax reduces (because some receptors don’t work)

Question 10

Dose response curve with agonist and partial agonist

Answer 10

-ED50 stays
-Emax reduces (because partial agonist have weaker response)

Question 11

TD50
LD50

Answer 11

-50% individuals receive toxicity
-50% individuals die

-drug can be 0% lethal at 100% response (good)
-Can be 50% lethal at 70% response (not good)

Question 12

Therapeutic index

Answer 12

-Diff between LD50 and ED50
-Large = safe
-Small = unsafe

-Helps with range its safe to use drug

Question 13

ED50

Answer 13

How much agonist is needed to reach 50% of full effect

Question 14

Withdrawl

Answer 14

-Physical and psychological symptoms when someone stops using a drug

Question 15

Sensitization

Answer 15

-Body becomes more sensitive to the drug
-More receptors available
-Body will do this in response to withdrawl

Question 16

Tolerance

Answer 16

-Body becomes less responsive to drug/ weakens it
-Down regulates receptors available
-To keep homeostasis and protection