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Micro Bio > Exam 2-hypersensativity > Flashcards

Exam 2-hypersensativity Flashcards

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Biology 101 flashcards
1
Q

hypersensativity

A

exaggerated immune response damages host tissue

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2
Q

sensatized

A

mount normal response

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3
Q

when does hypersensative rxn happen

A

SUBSEQUENT EXPOSURES; Not on first exposure, must be 2nd, 3rd..

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4
Q

Type 1

A

IgE-anaphylaxi/degranulation-allergies; FAST (30 sec)

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5
Q

Type II

A

Antibody mediated

HOST CELL

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6
Q

Type III

A

IgG-immune complex mediated

SOLUBLE-Serum, Anthus, Percicius

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7
Q

Type IV

A

Delayed cell mediated; not antibodies-
CTL and macrophages
SLOW –> Tb and poison ivy

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8
Q

Mast cells vs basophil

A

Mast cell = stationary

Basophils=circulate in blood

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9
Q

binds IgG

A

Fc receptor on granulocytes such as histamine/basophils

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10
Q

Atopic individuals

A

form lots of IgE- Th2 -Th2 cells especially active in switching to IgE production
Also high affinity between Fc and IgE

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11
Q

crosslinking is caused by

A

binding of IgE

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12
Q

crosslinking of Fc receptors causes

A

inhibtion of adenylate cyclase –> reduces cAMP –> degranulation

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13
Q

Second Exposure

A

Antibody binds Fc receptors –> crosslinking –>inhibits adenylate cyclase –> reduction in cAMP –> degranulation

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14
Q

maintains inflammation

A

prostaglandins and leukotrienes

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15
Q

histamine causes

A

vasodilation, smooth muscle contraction, proteases increase mucous secretion

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16
Q

TNF Alpha

A

recruits more WBC to inflamed area

17
Q

BP and oxygen during allergic rxn

A

decreases b/c vasodilation increases permeability; oxygen decreases b/c irregular heartbeat

18
Q

control systemic analphlaxis with

A

epinephrine

19
Q

timeline for type 2

A

8 hours

20
Q

c3a and c5a

A

increase inflammation by attracting neutrophils and macrophages to target cell-also anaphylaxotoxins

21
Q

+RH

A

have the antigen

22
Q

-RH

A

do not have the antigen

23
Q

antibodies in o blood

A

A and B so only give 0

24
Q

Anti A/B activates ____ and destroys ___

A

complement; RBC

25
Q

hemolysis

A

transfusion –> agglutination and complement binding –> antibody and complement system activate mac causing lysis of cells

26
Q

Minus blood can recieve

A

all negative NOT positive; b/c + has antigen

27
Q

Positive blood

A

can recieve positive and negative b/c it has the Rh antigen so it will not react to it and Rh- does not have it so it does not matter if you recieve it

28
Q

Drug induced thrombocytopenic

A

haptens too small

Micro Bio (11 decks)

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