Exam 2-hypersensativity

Question 1

hypersensativity

Answer 1

exaggerated immune response damages host tissue

Question 2

sensatized

Answer 2

mount normal response

Question 3

when does hypersensative rxn happen

Answer 3

SUBSEQUENT EXPOSURES; Not on first exposure, must be 2nd, 3rd..

Question 4

Type 1

Answer 4

IgE-anaphylaxi/degranulation-allergies; FAST (30 sec)

Question 5

Type II

Answer 5

Antibody mediated

HOST CELL

Question 6

Type III

Answer 6

IgG-immune complex mediated

SOLUBLE-Serum, Anthus, Percicius

Question 7

Type IV

Answer 7

Delayed cell mediated; not antibodies-
CTL and macrophages
SLOW –> Tb and poison ivy

Question 8

Mast cells vs basophil

Answer 8

Mast cell = stationary

Basophils=circulate in blood

Question 9

binds IgG

Answer 9

Fc receptor on granulocytes such as histamine/basophils

Question 10

Atopic individuals

Answer 10

form lots of IgE- Th2 -Th2 cells especially active in switching to IgE production
Also high affinity between Fc and IgE

Question 11

crosslinking is caused by

Answer 11

binding of IgE

Question 12

crosslinking of Fc receptors causes

Answer 12

inhibtion of adenylate cyclase –> reduces cAMP –> degranulation

Question 13

Second Exposure

Answer 13

Antibody binds Fc receptors –> crosslinking –>inhibits adenylate cyclase –> reduction in cAMP –> degranulation

Question 14

maintains inflammation

Answer 14

prostaglandins and leukotrienes

Question 15

histamine causes

Answer 15

vasodilation, smooth muscle contraction, proteases increase mucous secretion

Question 16

TNF Alpha

Answer 16

recruits more WBC to inflamed area

Question 17

BP and oxygen during allergic rxn

Answer 17

decreases b/c vasodilation increases permeability; oxygen decreases b/c irregular heartbeat

Question 18

control systemic analphlaxis with

Answer 18

epinephrine

Question 19

timeline for type 2

Answer 19

8 hours

Question 20

c3a and c5a

Answer 20

increase inflammation by attracting neutrophils and macrophages to target cell-also anaphylaxotoxins

Question 21

+RH

Answer 21

have the antigen

Question 22

-RH

Answer 22

do not have the antigen

Question 23

antibodies in o blood

Answer 23

A and B so only give 0

Question 24

Anti A/B activates ____ and destroys ___

Answer 24

complement; RBC

Question 25

hemolysis

Answer 25

transfusion –> agglutination and complement binding –> antibody and complement system activate mac causing lysis of cells

Question 26

Minus blood can recieve

Answer 26

all negative NOT positive; b/c + has antigen

Question 27

Positive blood

Answer 27

can recieve positive and negative b/c it has the Rh antigen so it will not react to it and Rh- does not have it so it does not matter if you recieve it

Question 28

Drug induced thrombocytopenic

Answer 28

haptens too small