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Pathology 1 > Exam 2: Healing and Repair > Flashcards

Exam 2: Healing and Repair Flashcards

1
Q

The process by which lost or necrotic cells are replaced by vital cells

A

Repair

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2
Q

What are the 2 types of repair?

A
  1. Parenchymal regeneration

2. Fibrosis

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3
Q

repair of injured tissue by replacement of damaged tissue with cells of identical type, sometimes leaving no residual trace of the previous injury

A

Parenchymal regeneration

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4
Q

Parenchymal regeneration can only occur if what 2 things have been met?

A
  1. tissue has capability to regenerate

2. CT framework is maintained

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5
Q

Replacement by fibrous CT or fibroplasia

A

Fibrosis

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6
Q

Repair by fibrosis results in an inc in ____ within tissues

A

Collagen

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7
Q

The cells of the body are divided into 3 groups based on their regenerative capability

A
  1. Labile cells
  2. Stable/ quiescent cells
  3. Nondividing/permanent cells
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8
Q

Cells that continue to proliferate throughout life, continuously replacing destroyed cells

A

Labile cells

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9
Q

List some examples of labile cells:

A
  1. surface eptithelia
  2. lining mucosa
  3. Lining of GIT
  4. Urinary tract
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10
Q

These cells usually demonstrate a low normal level of replication. however can undergo rapid division in response to stimuli

A

Stable/quiescent cells

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11
Q

List some examples of stable cells

A
  1. epithelial cells of liver, kidney, lung, pancrease
  2. smooth m. cells
  3. Fibroblasts
  4. Bascular endothelial cells
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12
Q

These cells have left the cell cycle and cannot undergo mitotic division in postnatal life

A

Nondividing/ permanent cells

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13
Q

List some examples of Nondividing/ permanent cells?

A
  1. neurons

2. cardiac m. cells

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14
Q

Repair by CT?

A

fibrosis

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15
Q

What are the 4 components for the process of fibrosis?

A
  1. migration and proliferation
  2. deposition of ECM
  3. Formation of new blood vessels
  4. Maturation and organization of the scar
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16
Q

Factors favoring fibrosis over regeneration

A
  1. severe and prolonged tissue injury
  2. Loss of tissue framework
  3. large amts. of exudate
  4. lack of renewable cell pops.
17
Q

These cells usually demonstrate a low normal level of replication

A

Stable/Quiescent cells

18
Q

Examples of Stable cells

A
  1. Epithelial cells of liver, kidney, lung, pancrease
  2. Smooth m.
  3. Fibroblasts
  4. Vascular endothelial cells
19
Q

What are the 2 major consequences of Fibrosis?

A
  1. Loss of functional parenchymal tissue

2. Alteration of physical properties of tissue

20
Q

T/F. the process of repair begins late in inflammation

A

F. Early

21
Q

What is the hallmark of healing, and forms by 3-5 days?

A

Granulation tissue

22
Q

What are the 4 Zones of granulation tissue?

A
  1. Zone of necrotic debris and Fibrin
  2. Zone of macrophages + growing capillaries
  3. Zone of proliferating capillaries and fibroblasts
  4. Zone of mature fibrous CT
23
Q

Which zone of granulation tissue represents the oldest portion of the healing process

A

Zone of mature fibrosis and CT

24
Q

The process by which the amt. of collagen deposition is inc.

A

Maturation of Granulation tissue

25
Q

Granulomas and granulomatous inflammation corresponds to acute/chronic inflam.

A

Chronic

26
Q

______ is part of the repair process. Granulation tissue is characterized by large amounts of fibrous CT and neovascularization

A

Granulation tissue

27
Q

A process including CT replacement and regeneration by which restoration of tissue continuity is achieved

A

Wound healing

28
Q

What are the 2 types of Healing?

A
  1. Healing by first intention

2. healing by second intention

29
Q

What is healing by first intention

A

When there is little exudate and when tissue elements are closely approximated
Ex: surgical wounds

30
Q

What is healing by second intention?

A

Occurs when edges of wounds are widely separated

31
Q

T/F. the kidney has limited regenerative capability

A

T

32
Q

how does healing happen in the liver

A

Parenchymal regen.

Pathology 1 (19 decks)

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