Exam 2- glomerulonephritis

Question 1

what is glomerulonephritis

Answer 1

inflammatinon of glomeruli

Question 2

what is the golemruli

Answer 2

arterioles network in bowman cap in kidneys

Question 3

different in afferent and efferent arterioles in glomeruli

Answer 3

huge pressure difference- drives diffusion and osmosis

Question 4

kidneys are a big/little consumer of CO

Answer 4

BIG- 20%
need high enough BP to perfuse well

Question 5

levels of glomerulus

Answer 5

endothelium
basement membrane (GBM)
podocytes- makes urine

Question 6

type 3 hypersensitivity rxn

Answer 6

deposited into tissues and causes inflammation that results in death

Question 6

type 2 hypersensitivity rxn

Answer 6

direct cell death

Question 6

causes of glomerulonephritis

Answer 6

1. anti-GBM antibodies
2. circulating antigen deposited in GBM

Question 7

anti-GBM antibodies = what type of hypersensitivity

Answer 7

type 2

Question 8

circulating antigen deposited into GBM = what type of hypersensitivity

Answer 8

type 3

Question 9

triggers of glomerulonephritis

Answer 9

*strep/infections
berger disease-IgA
lupus
vasculitis
good paster’s syndrome- autoimmune that produces anti-GBM antibodies

Question 10

S/S of glomerulonephritis

Answer 10

H- hematuria
A- azotemia (inc. nitrogen in blood)
R- retention
P- proteinuria
dec GFR