[Exam 2] Chapter 24: Management of Patients with Chronic Pulmonary Disease (Page 634-665) Flashcards
What is COPD?
Respiratory disease of airflow obstruction involving the airways, pulmonary parenchyma or both
Parenchyma includes what?
Any form of lung tissue, including brochioles, blood vesels, alveoli
COPD is characterized by
airflow limitation that is not fully reversible (chronic bronchitis and emphysema)
What is Asthma considered to be?
Abnormal airway condition characterized by reversible inflammation
COPD, what is airflow limitation?
Progressive, associated with abnormal inflammatory respose to noxious particles or gases
COPD: Chronic inflammation causes
damage to tissues
COPD: Scar tissue in airways results in
narrowing
COPD: Scar tissue in the parenchyma decreases
elastic recoil (compliance)
COPD: Scar tissue in pulmonary vasculature causes
thickened vessel lining and hypertrophy of smooth muscle
COPD: Alveolar wall destruction leads to
loss of alveolar attachments and a decrease in elastic recoil
Chronic Bronchitis: What is this?
Disease of airway defined as presence of cough and sputum production for at least 3 months in each of 2 consecutive years.
Chronic Bronchitis: What happens to the ciliary?
Function is reduced, bronchial wall thicken, bronchial airway narrow and mucous may plug airways
Chronic Bronchitis: What happens to alveoli?
Become damaged, fibrosed, and alveolar macrophage function diminishes leading to more infections
Chronic Bronchitis: Patient is more susceptible to
respiratory infections due
Emphysema: What is this?
This describes abnormal distention of air spaces beyond the terminal bronchioles with destruction of the walls of the alveoli
Emphysema: DEcreased alveolar surface area in direct contact with capillaries decreases causing
an impaired oxygen diffusion which leads to hypoxemia
Emphysema: Hypoxemia results with
decreased carbon dioxide elimination
Emphysema: What is Cor Pulmonate?
One of the complications of emphysema, and is right-sided heart fialure brought on by long term high blood pressure in pulmonary arteries
Emphysema: What happens in Panlobular Emphysema?
Destruction of respiratory bronchiole, alveolar duct.Creates an enlarged airspace , causing expiration to become active and requiring muscle effort
Emphysema: What happens in Centrilobular Emphysema?
Changes take place mainly in center of seconday lobule causing a derangement of ventilation-perfusion ratios.
COPD, Risk Factors: Most important worldwide risk factor is
cigarette smoking
COPD,Clinical Manifestations: GEnerally a progressive disease characterized by what three primary symptoms?
Chronic Cough
Sputum Production
Dyspnea
COPD,Clinical Manifestations: Why is weight loss common?
Dyspnea interferes with eating and work of breathing is energy depleting.
COPD ,Clinical Manifestations: Why do some people deleveop “Barrel Chest”?
Results from more fixed position of the ribs in inspiratory positoin and from loss of lung elasticity.
COPD, Assessment and Diagnostic Findings: Pulmonary function studies help determine
diagnosis of COPD
Disease SEverity
Monitor Disease Progression
COPD, Assessment and Diagnostic Findings: Spirometry used to evaluate
airflow obstruction, which is determined by ratio o fFEV1 to FVC
COPD, Assessment and Diagnostic Findings: Why would arterial blood gas measures be obtained?
To assess baseline oxygenation adn gas exchange and are especially important in advanced COPD
COPD, Complications: What are the major life threatening complications of COPD?
Respiratory insufficiency and failure
COPD , Complications: What are some complications?
Pneumonia, Chronic Atelectasis, Pneumothorax, and Pulmonary Arterial Hypertension (Cor Pulmonale)
COPD , Medical Management: Therapeutic strategies include
promoting smoking cesssation, prescribing medications like bronchodilators and managing exacerbations.
COPD , Medical Management - Risk Reduction: Major RF with COPD is
environmental exposure, and it is modifiable. Most chronic is smoking.
COPD , Medical Management - Pharmacologic Therapy: What is use for Grade I (Mild) COPD?
Short acting bronchodilator
COPD , Medical Management - Pharmacologic Therapy: What is used for a Grade II /III COPD?
Short acting bronchodilator and regular treatment with one or more long lasting bronchodilators
COPD , Medical Management - Pharmacologic Therapy and Bronchodilators: Relieve bronchospasm by improving
expiratory flow through widening of the airways and promoting lungs with each breath. Alter smooth muscle tone and reduce airway obstruction.
Increases expiratory flow rate and eases dyspnea
COPD , Medical Management - Pharmacologic Therapy and Bronchodilators: Can be delievered by
pMDI, nebulization, or via oral route
COPD , Medical Management - Pharmacologic Therapy and Bronchodilators: What devices are available to allow medication to be inhaled
pMDI
Powder Inhalers
Spacers
Nebulizers
COPD , Medical Management - Pharmacologic Therapy and Bronchodilators: What is a pMDI?
Pressurized device that contains an aerosolized powder of medication.