Exam 2 Cardiac Flashcards
Describe the cardiac cycle.
The pumping action of the heart
- Repeated contraction (systole)
- Relaxation (diastole)
of the walls of the atria and ventricles
What is excitation contraction coupling?
Process by which an action potential in the plasma membrane of the muscle fiber triggers the cycle, leading to cross-bridge activity and contraction
a) Pulmonary valve
b) Tricuspid valve
c) Aortic valve
d) Mitral valve(bicuspid valve )
Critical role of the endothelium
All tissues depend on a blood supply and the blood supply depends on a)________, which form the blood vessel.
a)________ can adjust their number and arrangement to accommodate local requirements.
Vascular endothelial cells produce a number of essential chemicals including b)_______, c)________, d)________, and e)_______.
a) endothelial cells
b) vasodilators
c) vasoconstrictors
d) anticoagulants
e) growth factors
Cardiac cycle
What is the 5 phase?
- Atrial Systole
- Early Ventricular Systole
- Ventricular Systole
- Early Ventricular Diastole
- Late Ventricular Diastole
Systole=contraction
Diastole=relax
What stage is Isovolumetric Ventricular Contraction?
The 2nd Phase:
Early Ventricular Systole
What stage is Isovolumetric Ventricular Relaxation?
The 4th Phase:
Early Ventricular Diastole
What phase is the “rapid ejection period”?
The 3rd Phase:
Ventricular Systole
When does “ventricular filling” occur?
The 5th Phase:
Late Ventricular Diastole
Valves movement #1
Open tricuspid and mitral valves
valves are relax
Valves movement #2
- *Closed tricuspid and mitral valves**
- *Both ventricles are contracted**
When the right ventricle is full, the tricuspid valve closes and keeps blood from flowing backward into the right atrium when the ventricle contracts
When the left ventricle is full, the mitral valve closes and keeps blood from flowing backward into the left atrium when the ventricle contracts.
Valves movement #3
Open pulmonic and aortic valve
As the right ventricle begins to contract, the pulmonic valve is forced open.
Blood is pumped out of the right ventricle through the pulmonic valve into the pulmonary artery to the lungs.
As the left ventricle begins to contract, the aortic valve is forced open.
Blood is pumped out of the left ventricle through the aortic valve into the aorta. The aorta branches into many arteries and provides blood to the body.
Valves movement #4
- *Closed pulmonic and aortic valves**
- *ventricle finishes contracting and starts to relax**
When the right ventricle finishes contracting and starts to relax, the pulmonic valve snaps shut. This keeps blood from flowing back into the right ventricle.
When the left ventricle finishes contracting and begins to relax, the aortic valve snaps shut. This keeps blood from flowing back into the left ventricle.
What is the perfusion means?
Perfusion”=Think “ BLOOD Flow
What is the Systole and Diastole means?
Systole-constriction phase
Diastole-relaxation phase
The left ventricle connects nearly all organ systems
To pump oxygenated blood to the body
Thicker and more muscular
What is the Coronary circulation?
Blood supply to the heart, via coronary arteries
- Right coronary artery; arises from right/anterior aortic sinus
- Left coronary artery; arises from left aortic sinus
What three major vessels return blood to the heart?
- Superior Vena Cava
- Inferior Vena Cava
- Coronary Sinus
What is the difference between AV valves and semilunar valves?
AV valves
- Between the atria and ventricles
- Require chordae tendinea to prevent them from opening in the wrong direction
Semilunar valves
- Stronger and are half moon shaped
- Between the ventricles and the arteries leaving the heart
Systolic and diastolic blood pressure
Systolic blood pressure (the first and higher number) measures pressure inside your arteries when the heart beats
Diastolic blood pressure (the second and lower number) measures the pressure inside the artery when the heart rests between beats
Which term is determined by stroke volume, speed of ejection, and arterial distensibility?
Arterial pulse pressure
Mean arterial pressure
Diastolic pressure
Pulse pressure
Pulse pressure
Mean Arterial Pressure
It’s all about a)________
MAP—Normal range b)________
Minimum MAP to maintain tissue perfusion c)________
How do we calculate? d)________
a) TISSUE PERFUSION
b) 70-110 mmHg
c) >/= 65
d) MAP= 1 Systolic + 2 Diastolic *3
What is the Left Heart Failure?
Congestive Heart Failure
Left ventricle failure(systolic failure)
Fluid backs into the lung
Reduce injection fraction
What is the Congestive Heart Failure?
The heart doesn’t pump blood as efficiently as it should
Causes by coronary artery disease(high cholesterol, high BP)
Develops over years
Chronic end-stage heart disease
Can lead to circulatory inadequacies
Symptoms of left side of heat failure
What is the right Heart Failure?
Ventricle is too weak to pump enough blood to the lungs
Backs up in the systemic system
Chronic lung disease
Lung Infections
Symptoms of right side of heat failure
What is the coronary artery bypass graft?
CABG
Taking a blood vessel from another part of the body (usually the chest, leg or arm) and attaching it to the coronary artery above and below the narrowed area or blockage
What is the cause of DVT? 3
Venous Stasis
Venous Endothelial Damage
Hypercoagulable States
Thrombus Formation–Arterial
What cause is this?
Inflammation
Traumatic injury
Infection
What is the primary HTN?
Increased afterload
Overactivity of the RAAS
Insulin resistance
Increased vascular resistance
What is the secondary HTN?
Renal Disease
Adrenocortical tumors
Fix other problem BP go away
Medication
What is the 2 types of main reason of heart failure?
Systolic
Loss of Contractility
Ventricles can’t pump enough blood during systole
Diastolic
Loss of Relaxation
Ventricles can’t fill with enough blood during diastole
What is the factors of left heart failure?
Myocardial Infarction (MI)
Myocarditis
Cardiomyopathies
Increased ischemia
Increased workload (CO formula…?)
(Hypertension–High afterload)
What is the common causes of Congestive heart failure/CHF?
Pump failure
Impaired contractility
Increased workload
Arrhythmias: myocardial infarction, cardiomyopathies
Increased workload over a period of time
Causes ventricle to pump harder
HTN because heart must work harder
volume overload
Sodium content (kidney failure)
Why CHF is secondary disease?
Because it is the end result of another underlying and persisting condition.
- often called end stage cardiovascular disease
- slowly develops
What is the Preload?
the amount of blood returning to the heart
Initial stretching of the cardiac myocytes (muscle cells) prior to contraction
Volume of blood that enters the right atrium from the venous system
-Volume of blood in ventricles at the end of diastole
What is the Afterload?
- *The resistance against the heart has to pump**
- The resistance exerted by the pressure within the aorta against the left ventricle
- The amount of resistance that the ventricle must overcome in order to pump blood out of the heart
What is the Cardiac Output?
Amount of blood that the heart pumps out of the left ventricle each minute
What is the Stroke Volume?
Amount of blood within the ventricle that is ejected with each contraction
This can also be referred to as left ventricular ejection fraction
The higher the ___________ the more the heart has to work and the weaker it gets
afterload
afterload
How Does Chronic HTN Lead to HF?
- High aortic pressure against the left ventricle
- Left ventricular hypertrophy occurs
- Coronary artery blood flow becomes insufficient to supply the enlarged left ventricle
- Ischemia of left ventricle–>MI–>HF
Why does heart failure result in hypokalemia?
- In heart failure, blood volume increases because of excess water within the bloodstream
- The repeated stimulation of the RAAS increases the risk of hypokalemia
Left ventricular hypertrophy (LVH) is an adaptation to a persistently high:
b. cardiac preload
c. cardiac ischemia
d. cardiac depression
a. cardiac afterload
Which of the following factors will cause cardiac O2 demands to increase?
a. Increased End Diastolic Volume
b. Decreased Heart Rate
c. Increased End Systolic Volume
d. Decreased End Diastolic Volume
a. Increased End Diastolic Volume
Which coronary artery branch is responsible for perfusing the ventricular conduction system?
a. The Left Anterior Descending
b. The Left Circumflex
c. The Right Coronary Artery
d. The Left Anterior Descending
a. The Left Anterior Descending
Anginal cardiac ischemic pain is a form of
a. referred pain
b. psychosomatic pain
c. somatosensory pain
d. phantom pain
referred pain
GI distress, weight loss, and impaired liver function are signs of which kind of heart failure?
a. Right-sided heart failure
b. Left-sided heart failure
a. Right-sided heart failure
The physiologic compensatory responses to decreased cardiac function seen with chronic heart failure have what kind of effects:
a. Increased cardiac afterload
b. Increased cardiac preload
c. Increased heart rate and O2 demands
d. All of these
a. Right-sided heart failure
Inflammation of the heart tissue is also known as?
carditis
An unstable plaque in the coronary arteries can result in which of the following complications?
a. abnormal vasodilation
b. stable angina
c. myocardial infarction
d. hypertension
e. myocardial ischemia
C
In the development of primary hypertension, increased sympathetic nervous system (SNS) activity causes: (select all)
a. decreased heart rate
b. increased renal excretion
c. peripheral vasoconstriction
d. decreased insulin resistance
e. increased peripheral resistance
C, E
Dysfuntion in the normal secretion of natriuretic hormones affects renal absorption of:
a. water only
b. calcium
c. sodium
d. aldosterone
C
How is insulin resistance related to the development of primary hypertension?
Insulin resistance activates the sympathetic nervous system, contributes to the development of diabetes, dyslipidemia, and eventually atherosclerosis, and promotes thrombus formation
Insulin resistance contributes to increases in SNS activity, peripheral resistance, endothelial injury and thrombus formation.
What is the Atherosclerosis?
The build-up of fats, cholesterol, and other substances in and on the artery walls
A risk factor that is associated with atherosclerosis and primary hypertension is:
a. high sodium diet
b. advanced age
c. hyperhomocystenemia
d. a low potassium diet
B
Over time, sustained hypertension can result in which of the following problems?
Vascular remodeling
Over time, prolonged vasoconstriction can result in permanent remodeling of blood vessel walls.