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Year 2 CV > Exam 2, Blood vessels part 2, gomez > Flashcards

Exam 2, Blood vessels part 2, gomez Flashcards

1
Q

What is giant cell arteritis associated with

A

> 50 and with polymyalgia rheumatica

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2
Q

what is the most common vasculitis of elderly in US

A

giant cell arteritis

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3
Q

what can giant cell arteritis cause clinically

A

diplopia and permanent blindness
may cause giant cell aortitis and thoracic aortic aneurysm
can involve coronary aa
2/3 have anti-endothelial or anti-smooth muscle Ab

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4
Q

What is Takayasu arteritis

A

granulomatous inflammation of aorta and major branches

usually females

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5
Q

what are signs of takayasu arteritis

A

marked weakeneing os pulses and reduced BP in upper extremities
retinal hemorrhages and blindess
sometimes pulmonary and renal HTN

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6
Q

describe findings in polyarteritis nodosa

A

young adults
renal arterial involvemnt causes deaths, no glomerulonephritis
30% have hep B surface Ag/Ab complexes

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7
Q

what are symptoms of polyarteritis nodosa

A

malaise, fever, weight loss, HTN, abdominal pain, melena, muscular aches/pains, ulcers, infarcts, peripheral neuritis (mostly motor)

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8
Q

What is Tx for polyarteritis nodosa

A

steroids and cyclophosphamide

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9
Q

what type of necrosis occurs with polyarteritis nodosa

A

fibrinoid

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10
Q

what is the cause of kawasaki disease

A

anti-endothelial cell and smooth muscle autoAb

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11
Q

what is the main cause of acquired pediatric heart disease in North Aerica and Japan

A

kawasaki disease

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12
Q

what are signs and symptoms of kawasaki disease

A

fever, conjunctival and oral erythema (strawberry tongue!)
erosion edema of hands and feet
erythema palms and soles
desquamative skin rash and enlarged cervical lymph nodes

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13
Q

what syndrome is kawasaki disease assoc with

A

mucocutaneous lymph node syndrome

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14
Q

What ANCA is assoc with microscopuc polyangiitis

A

p ANCa MPO

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15
Q

what are signs and symptoms of microscopic polyangiitis

A

palpable purpura
necrotizing glomerulonephritis
pulmonary capillaritis
hemoptysis, arthralgia, abdominal pain or bleeding, hematuria, proteinuria, hemorrhage and muscle pain or weakness

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16
Q

what is the eosinophil rich small vessel vasculitis

A

churg strauss syndrome

17
Q

what is churg strauss syndrome associated with

A

allergic rhinitis, bronchial asthma, lung infiltrates and blood eosinophilia

18
Q

what ANA is churg strauss syndrome assoc with

A

pANCA and MPO

19
Q

what are signs and symptoms of small vessel vasulitis

A

palpable purpura

coronary arteritis and eosinophilic myocarditis

20
Q

what is behcet disease

A

neutrophilic vasculitis of small to medium aa

21
Q

what is the triple sy,ptom complex of behcets

A

recurrent oral apthous ulcers, genital ulcers and uveitis

22
Q

what gene is behcet associated with

A

HLA B51

23
Q

what is a pathergy test and which vasulitis is it associated with

A

a minor trauma like sterile pinprick causes huge exagerated reaction
behcet

24
Q

What is the triaf in wegener granulomatosis

A

acute necrotizing granulomas of upper and lower respiratory tract
necrotizing or granulomatous vasculitis affecting small to medium vessels in lungs mainly
renal disease (usually crescenteic GN with hemturia and sometimes proteinuria

25
Q

what ANCA is associated with wegener

A

PR3 ANCA c ANCA

26
Q

what type of necrosis do lungs undergo in wegeners

A

caseous

27
Q

clinical presentation of wegeners

A 
M>F ~ 40 yrs
persistnet pneumonitis, b/l nodular and cavity infiltrates
chronic sinusitis
mucosal ulcerations in nasopharynx
renal disease
skin rashes
muscle pains
articular involvemnet
fever
28
Q

what is Tx for wegeners

A

immunosuprresion (steroids, chemo and anti-TNF)

29
Q

what is thromboangiitis obliterans

A

segemental thrombosing acute anc chronic inflammation of medium sized and smallarteries
extends to veins and nerves

30
Q

what are signs of thromboangiitis obliterans (buerger disease)

A

beings before age 35
chronic ulcerations of toes, feet or fingers and gangrene
exercise induced instep claudication
severe pain

31
Q

What is thromboangiitis obliterans associated with

A

heavy cigarrete smoking

32
Q

what other disorders can have vasculitis

A

rheumatoid arthritis, SLE, malignancy, mixed cryoglobulinemia and Henoch-Schonlein purpura

33
Q

how do you trate lupus vasulitis vs antiphospholipid Ab syndrome

A

aggressive anti inflammartory Tx vs aggressive anticoagluant therapy

Year 2 CV (31 decks)

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