Exam 2, Blood vessels part 2, gomez

Question 1

What is giant cell arteritis associated with

Answer 1

> 50 and with polymyalgia rheumatica

Question 2

what is the most common vasculitis of elderly in US

Answer 2

giant cell arteritis

Question 3

what can giant cell arteritis cause clinically

Answer 3

diplopia and permanent blindness
may cause giant cell aortitis and thoracic aortic aneurysm
can involve coronary aa
2/3 have anti-endothelial or anti-smooth muscle Ab

Question 4

What is Takayasu arteritis

Answer 4

granulomatous inflammation of aorta and major branches

usually females

Question 5

what are signs of takayasu arteritis

Answer 5

marked weakeneing os pulses and reduced BP in upper extremities
retinal hemorrhages and blindess
sometimes pulmonary and renal HTN

Question 6

describe findings in polyarteritis nodosa

Answer 6

young adults
renal arterial involvemnt causes deaths, no glomerulonephritis
30% have hep B surface Ag/Ab complexes

Question 7

what are symptoms of polyarteritis nodosa

Answer 7

malaise, fever, weight loss, HTN, abdominal pain, melena, muscular aches/pains, ulcers, infarcts, peripheral neuritis (mostly motor)

Question 8

What is Tx for polyarteritis nodosa

Answer 8

steroids and cyclophosphamide

Question 9

what type of necrosis occurs with polyarteritis nodosa

Answer 9

fibrinoid

Question 10

what is the cause of kawasaki disease

Answer 10

anti-endothelial cell and smooth muscle autoAb

Question 11

what is the main cause of acquired pediatric heart disease in North Aerica and Japan

Answer 11

kawasaki disease

Question 12

what are signs and symptoms of kawasaki disease

Answer 12

fever, conjunctival and oral erythema (strawberry tongue!)
erosion edema of hands and feet
erythema palms and soles
desquamative skin rash and enlarged cervical lymph nodes

Question 13

what syndrome is kawasaki disease assoc with

Answer 13

mucocutaneous lymph node syndrome

Question 14

What ANCA is assoc with microscopuc polyangiitis

Answer 14

p ANCa MPO

Question 15

what are signs and symptoms of microscopic polyangiitis

Answer 15

palpable purpura
necrotizing glomerulonephritis
pulmonary capillaritis
hemoptysis, arthralgia, abdominal pain or bleeding, hematuria, proteinuria, hemorrhage and muscle pain or weakness

Question 16

what is the eosinophil rich small vessel vasculitis

Answer 16

churg strauss syndrome

Question 17

what is churg strauss syndrome associated with

Answer 17

allergic rhinitis, bronchial asthma, lung infiltrates and blood eosinophilia

Question 18

what ANA is churg strauss syndrome assoc with

Answer 18

pANCA and MPO

Question 19

what are signs and symptoms of small vessel vasulitis

Answer 19

palpable purpura

coronary arteritis and eosinophilic myocarditis

Question 20

what is behcet disease

Answer 20

neutrophilic vasculitis of small to medium aa

Question 21

what is the triple sy,ptom complex of behcets

Answer 21

recurrent oral apthous ulcers, genital ulcers and uveitis

Question 22

what gene is behcet associated with

Answer 22

HLA B51

Question 23

what is a pathergy test and which vasulitis is it associated with

Answer 23

a minor trauma like sterile pinprick causes huge exagerated reaction
behcet

Question 24

What is the triaf in wegener granulomatosis

Answer 24

acute necrotizing granulomas of upper and lower respiratory tract
necrotizing or granulomatous vasculitis affecting small to medium vessels in lungs mainly
renal disease (usually crescenteic GN with hemturia and sometimes proteinuria

Question 25

what ANCA is associated with wegener

Answer 25

PR3 ANCA c ANCA

Question 26

what type of necrosis do lungs undergo in wegeners

Answer 26

caseous

Question 27

clinical presentation of wegeners

Answer 27

``` M>F ~ 40 yrs persistnet pneumonitis, b/l nodular and cavity infiltrates chronic sinusitis mucosal ulcerations in nasopharynx renal disease skin rashes muscle pains articular involvemnet fever ```

Question 28

what is Tx for wegeners

Answer 28

immunosuprresion (steroids, chemo and anti-TNF)

Question 29

what is thromboangiitis obliterans

Answer 29

segemental thrombosing acute anc chronic inflammation of medium sized and smallarteries extends to veins and nerves

Question 30

what are signs of thromboangiitis obliterans (buerger disease)

Answer 30

beings before age 35 chronic ulcerations of toes, feet or fingers and gangrene exercise induced instep claudication severe pain

Question 31

What is thromboangiitis obliterans associated with

Answer 31

heavy cigarrete smoking

Question 32

what other disorders can have vasculitis

Answer 32

rheumatoid arthritis, SLE, malignancy, mixed cryoglobulinemia and Henoch-Schonlein purpura

Question 33

how do you trate lupus vasulitis vs antiphospholipid Ab syndrome

Answer 33

aggressive anti inflammartory Tx vs aggressive anticoagluant therapy