Exam 2- Antivirals

Question 1

What are the replication inhibitors?

Answer 1

nucleoside analogs-

Question 2

What is the CCR5 antagonist? How does it work?

Answer 2

Maraviroc for HIV- blocks HIV binding to CCR5 on macrophages and CD4 cells

Question 3

What does Ibalizumab do?

Answer 3

blocks CCR5 and CX

Question 4

What ending do HIV PROTEASE inhibitors have?

Answer 4

NAvir

Question 5

What ending does HCV PROTEASE inhibitors have?

Answer 5

PREvir

Question 6

What ending do INTEGRASE inhibitors have?

Answer 6

GRAvir

Question 7

What ending does HIV reverse transcriptase inhibitors have? How do they act?

Answer 7

INE

NONcompetitive inhibitor they bind to OTHER sites, NOT active site

Question 8

What drug is used for Ebola/Marburg (also maybe coronaviruses)?

Answer 8

Remdesivir

Question 9

What drug would be used for HSV and VZV strains that lack thymidine kinase?

Answer 9

Cidofovir– ** DOES NOT NEED THYMIDINE KINASE **

Question 10

What ending do HSV and VZV inhibitors have?

Answer 10

CLOvir

Question 11

What are the 3 influenza drugs that are neuraminidase inhibitors?

Answer 11

(Os Per Zan)

oseltamivir

peramivir

zanamivir

Question 12

What influenza drug blocks 5’ cap stealing?

Answer 12

Baloxavir marboxil

Question 13

Why is neuraminidase important?

Answer 13

it cleaves the sialic acid residues that newly formed viruses are attached to