Exam 2- Antifungals

Question 1

What are the polyenes and what do they target?

Answer 1

Amphotericin B and Nystatin

target ergosterol

Question 2

How can the nephrotoxicity of the polyenes be reduced?

Answer 2

administer saline prior or by using liposomal formulation

Question 3

What are the azoles and what do they target?

Answer 3

Imidazole and Micronazole and Triazoles (Itra, Fluco, and Isa)

target 14 alpha dimethylase

Question 4

What are the allylamines and what do they target?

Answer 4

terbinafine

targets squalene epoxidase (P450)

Question 5

What are the echinocandins and what do they target?

Answer 5

Caspofungin and Micafungin

targets beta 1-3 glucan synthesis

Question 6

What antifungal attacks the mitotic spindles during fungal replication?

Answer 6

griseofulvin

Question 7

What antifungal inhibits thymidylate synthase to interrupt replication?

Answer 7

flucytosine

Question 8

What drug must be taken with flucytosine?

Answer 8

amphotericin B