Exam 2 Flashcards
zygote
from fertilization to 4 days old
blastula or blastocyst
hollow ball of cell forms around 4-5 days
gastrula
3 layered ball of cells forms 7-10 days
ectoderm
outer layer, forms skin and nervous systems
mesoderm
middle layer, forms muscle blood and bone
endoderm
inner layer, forms internal organs lungs liver intestines
neural plate
part of the back ectoderm that forms the neural tube by folding in on itself
neural tube
hollow tube of cells that eventually forms the spinal cord and brain
neural crest
these cells eventually migrate out and form the peripheral nerves
cell proliferation
the formation of two new cells from one cell
cell migration
the movement of cells from one place to another
cell differentiation and maturation
the process by which unspecialized stem cells or precursor cells take one their final specialized state
synaptogenesis
the formation of a functional synapse between an axon from a presynaptic neuron and the dendrites of a post synaptic neuron
myelination
the formation of myelin sheaths and neurons
The process of neural migration
starts around 8-9 weeks post conception and is complete 2-3 months before birth
two main types of migration
tangential and radial
tangential
moving up/down or around
radial
moving out from center
Tangential migration of neural crest cells to form
Schwann cells and neurons in peripheral nerves
Radial migration of cerebral cortical neurons to form
layers of the cerebral cortex
The processes associated with neuronal maturation
chemical differentiation
morphological differentiation
Chemical differentiation
hormones and other chemical signals activate master regulatory genes specific proteins done by birth
master regulatory genes
genes that produce a protein that then turn on neuron
morphological differentiation
cell taking on its adult form- dendrites and axons begin to form continues into childhood
The role of chemoattractants and adhesion molecules in process of axonal extension
1) secretion of chemoattractants from the target cell that guide the axon to them
2) cell adhesion molecules that then grasp the axon and adhere it to the target cell
Synaptogenesis process
starts during prenatal development and continues into late childhood
Creation of proper synaptic structure by cellular activites in both neurons
1) pre synaptic neuron needs to synthesize and store neurotransmitter vesicles
2) post synaptic neuron needs to form and insert neurotransmitter receptors into membrane
Neuronal cell death and synaptic pruning
post-synaptic cells secrete neurotrophins which promote survival of neurons. Neurons with a stronger connections get more neurotropic support those with weaker connections don’t and eventually die. This ‘scuplts’ away neurons with weaker connections, leaving only ones with strong functional connections
Which regions of the brain undergo myelination first and which under go it last
Regions controlling basic sensory analysis and simple movement myelinate first, regions involved with decision making and impulse control myelinate last