EXAM 2 Flashcards
What is the average heart rate
75 beats/minute
Without the nervous system control the heart would beat about…
100 beats/minute (intrinsic SA node depolarization rate due to leak channels)
Why would there be a difference in heart rate without the nervous system control?
The autonomic nervous system modulates SA node activity
Visceral motor responses are initiated from…
Internurons in “brain centers”
A center is a collection of interneurons that _____ _____ input about a specific function and create ______ ______ to alter that function
Receive sensory
Motor output
Cardiovascular control centers include…
Cardiac control (heart)
- cardioacceleratory center
- cardioinibitory center
Vasomotor center
Together the cardiac control and vasomotor center regulate ..
Blood pressure and heart function
Interneurons of the cardiioacceleratory center will lead to an
Increase in heart rate
Postganglionic neuron of the cardioacceletory system secretes
Norepinephrine (NE)
Adrenergic receptors (in the cardioacceletory system) on cells of the SA node bind to…
Norepinephrine, causing an increased rate of action potentials of SA node
Interneurons of the cardioinhibitory center will lead to..
A decrease in heart rate
Visceral motor neurons are a part of what system
The parasympathetic system
Postganglionic neurons of the cardioinhibitory systems secrete..
Acetylcholine (ACh)
Cholinergic receptors on cells (in the cardioinhibitory center) of the SA node bind to
ACh
- this allows potassium to leave the cell - hyperpolarizing reaction
- rate of action potentials decrease
Sensory input is integrated to create..
Motor output to SA node
What are proprioceptors
Sensory input from muscles and tendons
- informs brain on changes in physical activity
What are baroreceptors
Sensory input from blood vessels
- informs brain on changes to pressure in vessels
What are chemoreceptors
Sensory input from blood vessel
- informs brain on changes carbon dioxide or oxygen levels in the blood
- important in respiratory system, but has some affect on heart rate
_____ _____ paths are associated with heart rate
Visceral motor
Blood vessels are dynamic structures that control…
The delivery of blood to/from body tissues
What is the function of arteries and what are examples of arteries
Carry blood away from heart
- elastic arteries
- muscular arteries
- arterioles
What are capillaries
Thinnest type of blood vessel involved in gas exchange
What is the function of veins and examples of veins
Returns blood to the heart
- venules
- small veins
- large veins
The largest volume of blood is located in the…
Veins and venules
What are the three layers of tissue that make up most blood vessels
Tunica intima, tunica media, and tunica externa
What is the tunica intima
Similar structure to anatomical membranes
Consists of one layer of epithelial cells (endothelium) and thin layer of connective tissue (subendothelial layer)
Arteries only: internal elastic membrane
Inner layer
The endothelium is a _______ _______ ________
Selectively permeable barrier
- cells regulate what enters/exits bloodstream
- smooth surface normally repels blood cells and platelets
What is the tunica media
Middle layer
Smooth muscle layer
Elastic fibers (in arteries only!)
What is vasomotion and what controls it
Contraction or relaxation of smooth muscle
- smooth muscle controls vasomotion, especially in arteries
What is vasoconstriction
Contraction of tunica media
What is vasodilation
Relaxation of tunica media
Smooth muscle cells have an internal network of _____ and ______ connected to ______ _______
Actin
Myosin
Dense bodies
What is seen at an internal view of smooth muscle
Network of myosin and actin connected at dense bodies (collection of proteins, like z-disks)
What is seen at the surface view of smooth muscle (relaxed)
Dense bodies also connect to network of intermediate filaments (provide “skeleton” for cells) AND to neighboring cells
What is seen on smooth muscle during contraction
Myosin and actin interact when calcium levels increase, resulting in contraction
How is smooth muscle excited
It is excited by neurotransmitters released from autonomic efferent neurons into diffuse junctions
Action potentials from ANS result in…
Excitation of many smooth muscle cells… this is different from skeletal muscle
What is the tunica externa
The outermost layer
Connective tissue with mostly COLLAGEN
Anchor vessel to surrounding tissues
Vasa vasorum - vessels of the vessels
What are the three types of arteries
Elastic, muscular and arterioles
What do elastic arteries act as
Pressure reservoirs
(Expand and recoil as heart ejects blood)
What are muscular arteries
Deliver blood to specific body organs
More muscle in tunica media - responsible for vasoconstriction
What are arterioles
Smallest artery = many only have two layers
Feed into capillary beds
Vasoconstriction/dialation control blood flow into capillary beds
Blood within arterioles has lots of resistance - also called resistance vessels
What are aneurysms
A balloon like bulge in the wall of a blood vessel due to weakened arterial walls
- may be heredity or acquired
What is scurvy
A nutritional deficiency
Lack of vitamin C in diet disrupts proper production of collagen
- results in weakened blood vessels - spontaneous bruising
- also swollen gums (same reason as above) and loss of teeth (collagen is important in bone/teeth health)
What do capillaries connect
Arterioles and venules
Capillaries are the major site of exchange between…
Blood and tissues
Only _____ _______ is present to promote rapid diffusion of material from blood into tissue or vice versa
Tunica intima
Flow of blood through capillary beds is controlled by…
Sphincter muscle cells
Only about _____ of body’s capillary beds are “open” at any given time
1/4
This is because capillary beds are “open” (perfused) or “closed” based on contraction of sphincters
What does perfused mean
When the capillary beds are open
_______ ________ funnels blood through a “closed” capillary bed
Thoroughfare channel
Relaxed _______ ______ allow perfusion of “true capillaries”
Precapillary sphincters
What are the two major types of capillaries in our bodies
Continuous and fenestrated
What are the most common type of capillary
Continuous capillaries
What are some characteristics of continuous capillaries
Least permeable
Wall of vessel is a single endothelial cell thick
Cells overlap to make intercellular clefts where some molecules can travel through via diffusion
______ _________ have pores between endothelial cells
Fenestrated capillaries
What are some characteristics of fenestrated capillaries
Pores between endothelial cells
More permeable
Found in locations where rapid transport is important
Where are fenestrated capillaries found
Locations where rapid transport is important like kidneys and small intenstines
What are some characteristics of sinusoidal capillaries
Most permeable
Large fenestrations and incomplete basement membrane
Only found in limited locations like the liver and spleen
Where are sinusodial capillaries found
Limited locations like the liver and spleen
Gases and nutrients pass between the blood and interstitial fluid via _________ at capillaries
Diffusion
What are the two major routes for diffusion through capillaries
- through a cell
- through spaces between cells
Does water move across the capillary walls
Yes
What is filtration
Net movement of water out of capillaries
What is reabsorption
Net movement of H2O into capillaries
Direction of water movement depends on
Osmosis and hydrostatic (blood) pressure
______ are blood reservoirs (pool blood due to low pressure) that return blood to the heart
Veins
Capillaries beds drain into…
Venules, medium-sized veins, large veins, heart