Exam 2 Flashcards
Microbial protein antigens are mainly captured by….
dendritic cells
Where are captured antigens concentrated and immune responses initiated?
lymph nodes
MHC Class 1 proteins are recognized by what cells?
CD8+ cells
MHC Class 2 proteins are recognized by what cells?
CD4+ cells
What MHC molecules trigger immediate cell apoptosis?
MHC Class 1
How are antigens for display by MHC Class 1 molecules created?
ubiquinated and broken down by proteosome into peptide fragments
Where in the cell do antigen fragments first meet MHC Class 1 molecules?
transported to ER by TAP
In order for an MHC molecule to trigger an effector response in CD4+ or CD8+ cells, it must present antigens along with a….
costimulator
Mucosal epithelial cells express MHC Class ___ molecules. These mobilize _________ lymphocytes to combat the infection.
- one
- cytotoxic T
What types of antigens are recognized by antibodies and not T Cell receptors?
polysaccharides
What types of antigens are recognized by T cell receptors?
protein/peptide antigens
What two mechanisms do activated T cells use to activate antigen presenting B cells to proliferate and differentiate?
- CD40 ligand
- cytokine secretion (CD40 engagement cytokines)
IL-2 release is stimulated by what? IL-2 causes what?
- triggered by CD28 activation by B7
- IL-2 causes T-Cell proliferation
What is the most important costimulator for naive T cell activation?
B7 ligand
What stimulates the production of B7 molecules?
-components of the innate immune system recognizing PAMPs with TLRs. Antigen presentation without TLR activation means it it likely self antigen
