Exam 1 - Sulfanylureas 2nd Gen

Question 1

What are the characteristics of 2nd Generation Sulfanylureas?

Answer 1

● Longer DOA than 1st generation
● Hypoglycemic agents ( 100x more potent ) than 1st generation agents (Bad if OD)
● Same side effects as 1st generation agents
● Weight gain

Question 2

Which are the 2nd Generation Sulfanylureas drugs?

Answer 2

Glyburide ( Micronase )
Glipizide ( Glucotrol )
Glipizide XL ( Glucotrol XL )
Glimepiride ( Amaryl )

Question 3

What are the characteristics of Glyburide ( Micronase )?

Answer 3

● QD – BID dosing

● Liver metabolism

Question 4

What are the characteristics of Glipizide (Glucotrol) and Glipizide XL (Glucotrol XL)?

Answer 4

● Shortest DOA (Glipizide) = use BID
● Extended length (XL) = QD
● Liver Metabolism

Question 5

What are the characteristics of Glimepiride ( Amaryl )?

Answer 5

● QD dosing