Exam 1 - Dipeptidyl­ peptidase­ 4 Inhibitors

Question 1

What are the characteristics of the DPP4 inhibitors?

Answer 1

• Inhibit the metabolism of GLP­1 and GIP, thereby increasing their duration of effectiveness.
• SE’s = upper respiratory infections, runny nose, nasopharyngitis,headache rare hypersensitivity rxns,

Question 2

Which are the DPP4 inhibitor drugs?

Answer 2

Saxagliptin ( Onglyza )
Linagliptin (Tradjenta)
Alogliptin (Nesina)

Question 3

What do the DPP4 inhibitor drugs end in?

Answer 3

gliptin

Question 4

What are the characteristics of Saxagliptin ( Onglyza ) Linagliptin (Tradjenta)
Alogliptin (Nesina)?

Answer 4

All 4 agents are used orally QD Monotherapy or add­on
● Weight neutral
● Very low incidence of S.E.
● Type­2 diabetics ONLY
● NOT indicated for use with insulin
● Delays gastric emptying (decreases the rate and extent of absorption of other drugs)(take other drugs at least 1 hour before dosing, especially antibiotics and contraceptives)
● Pancreatitis (rare)

Question 5

What is a characteristic specific to Linagliptin (Tradjenta)?

Answer 5

No need for dose adjustment in renal failure with linagliptin (excreted in the bile, not the kidneys)

Question 6

What is DPP4?

Answer 6

• DPP­4 is a serine protease widely distributed throughout the body on endothelial cells, on the surface of T­-lymphocytes, and in a circulating form.
• DPP­4 may be important enzyme involved in proper immune system functioning