Exam 1 - Meglinitides

Question 1

What are the characteristics of Meglinitides?

Answer 1

● Hypoglycemic agents
● MOA : Close K+ ATP channel→
depolarization of β­cell → open Ca+
channel → insulin release
● Weight gain
● Administered before meals to reduce post­prandial glucose levels
● Short half­lives (1 hr Repaglinide, 3 hr Nateglinide)
● No sulfa allergy
● S.E. = Weight gain, GI upset, headache, hypoglycemia

Question 2

Which are the Meglinitide drugs?

Answer 2

Repaglinide ( Prandin )

Nateglinide ( Starlix )

Question 3

What do the Meglinitides end in?

Answer 3

glinide