exam 1 regulatory enzymes krebs Flashcards
what would inhibit pyruvate dehydrogenase?
product: high NADH high acetyl CoA high ATP LCFA
*these conditions activate a kinase which adds a phosphate group to pyruvate dehydrogenase to inactivate it
what inhibits citrate synthase?
high product:
ATP
citrate
low reactant:
oxaloacetate or acetyl CoA
isocitrate dehydrogenase is regulated by?
energy charge- high energy inhibits (ATP and NADH)
low energy stimulates (ADP, NAD+)
a-ketoglutarate dehydrogenase is regulated by?
energy charge-
inhibited by: high ATP, NADH or succinyl CoA
succinyl CoA inhibiting a-ketoglutarate dehydrogenase is an example of?
a product inhibiting its enzyme
what are the final products of aerobic metabolism of carb, fat and protein?
CO2 and water
what is the purpose of the krebs cycle?
make ATP and reduced compounds
dehydrogenates are named after?
what they oxidize
what does the krebs cycle send to the ETS?
NADH and FADH2
in the krebs cycle, _____ inhibit and _______ stimulate?
products, reactants
what are the products that inhibit krebs?
ATP
high energy charge
NADH
FADH2
what are the reactants that stimulate krebs?
ADP or AMP low energy charge NAD+ FAD acetyl CoA
where is the krebs cycle located?
mitochondrial matrix
