Exam 1 Pharmacokinetics Flashcards
Who writes drug prescribing information
drug companies
who approves drug prescribing information?
FDA
What is pharmacokinetics?
the way the drug moves in and through the body
What is LADME?
Liberation Absorption Distribution Metabolism Elimination
You can’t get absorption until you have ____.
Liberation
drug movement through compartments
distribution
drug removal from body
elimination
transformation of parent compound
metabolism
drug enters circulation
absorption
drug release- from whatever dosage form it is
liberation
Tpk
time to peak concentration
F means
fraction of drug that is bioavailable
PPB means
protein binding
Vd means
volume of distribution
T1/2
Half life
How can liberation be modified?
by making drug buffered,
enteric coated, delayed/controlled/extended,
sustained release,
and abuse resistant
what is the purpose of enteric coated medicine?
it won’t dissolve until it gets into intestine
traditional liberation
a tablet dissolving/breaking apart in liquid
buffered medicine changes liberation how?
medicine needs to be in basic environment to disassociate.
example of buffered medicine
aspirin
4 different types of movement across membranes that is involved in absorption
Passive diffusion
Active transport
Facilitated diffusion
Endocytosis
most common absorption movement
passive diffusion
movement of molecules is gradient driven (concentration dependent.
passive diffusion
in passive transport, Rate of transport is dependent on ____.
concentration gradient