Exam 1: Genitourinary Flashcards
Genitourinary System Differences
- Healthy infant, kidneys operate at functional level appropriate for body size (however function is reduced when the infant is under stress)
- By 6-12 months, kidney function is nearly that of an adult
- Young infant kidneys cannot concentrate urine as efficiently as those of older children and adults. Susceptibility to acemia.
- Neonates bladder, which is in lower abdominal cavity, gradually sinks into pelvic cavity during early childhood.
- Young children have shorter urethral, predisposing them to UTI’s.
- Unlike adults, most children with acute renal failure regain normal function.
When do children gain complete bladder control?
4-5 y/o
Why are young infant’s kidney not able to concentrate urine as efficiently as those of older children and adults?
- Because loops of Henle are not long enough to reach inner medulla.
- After few weeks of life, ability of kidneys to acidify urine reaches adult levels.
Nephrotic Sydrome clinically includes
- Massive proteinuria
- Hypoalbuminemia
- Hyperlipidemia
- Edema
Two Types of Nephrotic Syndrome
- Primary: restricted to glomerular injury
2. Secondary: Develops as a part of systemic illness
What are clinical manifestations of nephrotic syndrome?
- Weight gain
- Puffiness in the face
- Edema → intestinal mucosa, abdominal
- Urine → decreased volume, darkly opalescent and frothy ( a lot of bubbles)
- Skin pallor
- Irritability
- Increased susceptibility to infection
Diagnostic symptoms of nephrotic syndrome
- Massive proteinuria
- High specific gravity
- Elevated cholesterol & platelet count
Treatment for Nephrotic Syndrome
Corticosteroid therapy
- PO for 3 months straight
- DO NOT STOP ABRUPTLY
- May become dependent
- Many side effects
Nephrotic Syndrome relapses can occur if
Response to corticosteroid therapy is poor.
Nursing care for nephrotic syndrome
- Monitor intake and output daily
- Monitor for skin breakdown → change diapers frequently and change positions frequently
- Susceptible to upper respiratory tract infections → steroids bring resistance down
Vesicoureteral Reflux
- Retrograde of bladder urine into the ureters: the urine that is supposed to be stored in the bladder is now going back up through the ureters.
- Most common cause of pyelonephritis in children.
Management of Grade I and II Vesicoureteral Reflux
- Conservative therapy with continuous low-dose ABT and frequent urine cultures (as long as they don’t have continuous UTIs).
- Usually high incidence of spontaneous resolution (children are small and the ureters may form a loop near the bladder but as they grow older the ureters will straighten out)
Management of Grade III Vesicoureteral Reflux
Management conservatively unless complications
Management of Grade IV and V Vesicoureteral Reflux
-Surgical correction is required: surgery will place ureters higher up on the bladder
Hypospadius
- Urethral opening that is located below the glans penis.
- Can be anywhere along the ventral surface.
Characteristics of Hypospadius
- Foreskin is usually absent ventrally.
- May have undescended testes.
- May be mistaken for female genitalia.
Surgical Repair of Hypospadius
- Do not circumcise → the skin from the circumcision will be used in the repair
- Urinary diversion may be necessary after repair → avoid tub baths until recovered, never clamp together
- Avoid certain toys especially right after surgery (i.e ride along toys)
HUS (Hemolytic Uremic Sydnrome) is an acute disease characterized by a triad of manifestations including:
- Acute renal failure
- Hemolytic Anemia
- Thrombocytopenia
Hemolytic Uremic Syndrome (HUS) is caused by
- No causative agents identified -> many pathogens associated.
- Usually follows URI or GI disease.
Clinical Manifestations of HUS
- Episode of diarrhea and vomiting
- Anorexia
- Irritable & Lethargic
- Pallor
- Bruising, purpura, rectal bleeding
- Anuria
- HTN
- Seizures
How is HUS diagnosed?
- Triad is sufficient for diagnosis → proteinuria, hematuria, elevated creatinine and BUN
- Urinary casts
- Low Hgb and Hct
- High reticulocyte count
Management of HUS
- Recognize what it is that is going on and counteract it. If this is done, there is 95% change of full recovery
- Fluid replacement
- HTN treatment
- Correction of acidosis and electrolyte imbalance
- Hemodialysis
- Blood transfusions
- TPN
- Symptom treatment
Glomerulonephritis
- Immune complex disease
- Most cases are post infectious associated with pneumococcal, streptococcal and viral infections.
Glomerulonephritis: Latent period
10-14 days after infection
Glomerulonephritis Incidence
- Primarily affects school-age children; peak onset 6-7 y/o; uncommon in <2 years.
- Most common in winter and spring.
- Second attacks are rare
Glomerulonephritis: The kidneys
- Appears normal to moderately enlarged.
- Decreased GFR
- Microscopic exam: diffuse proliferations and exudative process