Exam 1 - Adhesion Molecules Flashcards
What are the molecules that control the migration of leukocytes and lymphocytes from blood into peripheral tissue called?
Adhesion molecules
What controls the migration of molecules from blood into tissue?
Vascular Endothelium
What is the term for the process of leukocytes migrating to the tissue from circulation during injury, inflammation, and peripheral lymphoid organs?
Extravasation
Name the 4 subsets of adhesion molecules.
1) Integrins
2) Selectins
3) Immunoglobulin Superfamily
4) Cadherins
What is the subset of adhesion molecules that are membrane glycoproteins which are composed of two subunits, an alpha and beta chain?
INTEGRINS
Where are Integrins expressed?
On Leukocytes
T/F: Integrins require activation for binding to their ligands.
TRUE
-Present on leukocytes, at all times, and need to be induced
What is the subset of adhesion molecules that are a family of membrane glycoproteins and bind to specific carbohydrates containing sialylated moieties?
SELECTINS
Where are Selectins expressed?
On multiple types of cells
Name the 3 types of Selectins.
1) Leukocyte (L)-selectins
2) Endothelial (E)-selectins
3) Platelet (P)-selectins
What type of selectins are expressed on leukocytes?
L-selectins
What type of selectins do vascular endothelial cells express?
E-selectins & P-selectins
T/F: Initial binding of leukocytes with vascular endothelium involves selectins.
TRUE
What is the name of the subset of adhesion molecules that are glycoproteins that contain a variable number of immunoglobulin-like domains?
IMMUNOGLOBULIN SUPERFAMILY
What are the four classes of Immunoglobulin Superfamily molecules?
1) Intercellular adhesion molecule (ICAM)
2) Vascular cell adhesion molecules (VCAM)
3) Neural cell adhesion molecules (NCAM)
4) Platelet-endothelial cell adhesion molecules (PECAM)
